1 to 10 of 60 literature results

• Adjuvant therapy with pegylated interferon alfa-2b versus observation alone in resected stage III melanoma: final results of EORTC 18991, a randomised phase III trial.

  BACKGROUND: Any benefit of adjuvant interferon alfa-2b for melanoma could depend on dose and duration of treatment. Our aim was to determine whether p…

  Authors: Alexander M M Eggermont, Stefan Suciu, Mario Santinami, Alessandro Testori, Wim H J Kruit, Jeremy Marsden, Cornelis J A Punt, François Salès, Martin Gore, Rona Mackie,…

  Source: Lancet. 2008 Jul 12

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• Autoimmune antibodies and recurrence-free interval in melanoma patients treated with adjuvant interferon.

  BACKGROUND: Appearance of autoantibodies and clinical manifestations of autoimmunity in melanoma patients treated with adjuvant interferon (IFN)-alpha…

  Authors: Marna G Bouwhuis, Stefan Suciu, Sandra Collette, Steinar Aamdal, Wim H Kruit, Lars Bastholt, Ulrika Stierner, François Salès, Poulam Patel, Cornelis J A Punt,…

  Source: Journal of the National Cancer Institute. 2009 Jun 16

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• Endpoints in adjuvant treatment trials: a systematic review of the literature in colon cancer and proposed definitions for future trials.

  Disease-free survival is increasingly being used as the primary endpoint of most trials testing adjuvant treatments in cancer. Other frequently used e…

  Authors: Cornelis J A Punt, Marc Buyse, Claus-Henning Köhne, Peter Hohenberger, Roberto Labianca, Hans J Schmoll, Lars Påhlman, Alberto Sobrero, Jean-Yves Douillard

  Source: Journal of the National Cancer Institute. 2007 Jul 4

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• CAIRO and FOCUS.

  Authors: Matthew T Seymour, Cornelis J A Punt

  Source: Lancet. 2007 Dec 8

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• Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-alpha production.

  C-type lectin receptors (CLRs) fulfill multiple functions within the immune system by recognition of carbohydrate moieties on foreign or (altered) sel…

  Authors: Friederike Meyer-Wentrup, Daniel Benitez-Ribas, Paul J Tacken, Cornelis J A Punt, Carl G Figdor, I Jolanda M de Vries, Gosse J Adema

  Source: Blood. 2008 Apr 15

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• Migration of dendritic cell based cancer vaccines: in vivo veritas?

  Ex vivo generated cancer vaccines based on dendritic cells (DCs) are currently applied in the clinic. The migration of DCs from the tissues to the lym…

  Authors: Gosse J Adema, I Jolanda M de Vries, Cornelis J A Punt, Carl G Figdor

  Source: Current opinion in immunology. 2005 Apr

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• Sequential versus combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (CAIRO): a phase III randomised controlled trial.

  BACKGROUND: The optimum use of cytotoxic drugs for advanced colorectal cancer has not been defined. Our aim was to investigate whether combination tre…

  Authors: Miriam Koopman, Ninja F Antonini, Joep Douma, Jaap Wals, Aafke H Honkoop, Frans L G Erdkamp, Robert S de Jong, Cees J Rodenburg, Gerard Vreugdenhil, Olaf J L Loosveld,…

  Source: Lancet. 2007 Jul 14

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• Post-surgery adjuvant therapy with intermediate doses of interferon alfa 2b versus observation in patients with stage IIb/III melanoma (EORTC 18952): randomised controlled trial.

  BACKGROUND: Individuals affected by melanoma with thick primary tumours or regional node involvement have a poor outlook, with only 30-50% alive at 5 …

  Authors: Alexander M M Eggermont, Stefan Suciu, Rona MacKie, Wlodzimierz Ruka, Alessandro Testori, Wim Kruit, Cornelis J A Punt, Michelle Delauney, François Sales, Gerard Groenewegen,…

  Source: Lancet. 2005 Oct 1

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• Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy.

  The success of cellular therapies will depend in part on accurate delivery of cells to target organs. In dendritic cell therapy, in particular, delive…

  Authors: I Jolanda M de Vries, W Joost Lesterhuis, Jelle O Barentsz, Pauline Verdijk, J Han van Krieken, Otto C Boerman, Wim J G Oyen, Johannes J Bonenkamp, Jan B Boezeman, Gosse J Adema,…

  Source: Nature biotechnology. 2005 Nov

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• In situ expression of tumor antigens by messenger RNA-electroporated dendritic cells in lymph nodes of melanoma patients.

  Electroporation of dendritic cells (DC) with mRNA encoding tumor-associated antigens (TAA) for cancer immunotherapy has been proved efficient and clin…

  Authors: Danita H Schuurhuis, Pauline Verdijk, Gerty Schreibelt, Erik H J G Aarntzen, Nicole Scharenborg, Annemiek de Boer, Mandy W M M van de Rakt, Marieke Kerkhoff, Marie-Jeanne P Gerritsen, Femke Eijckeler,…

  Source: Cancer research. 2009 Apr 1

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