10 literature results

• Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice.

  The muscular dystrophies are a heterogeneous group of disorders for which there are currently no cures. Oculopharyngeal muscular dystrophy (OPMD) is a…

  Authors: Janet E Davies, Lin Wang, Lourdes Garcia-Oroz, Lynnette J Cook, Coralie Vacher, Dominic G O'Donovan, David C Rubinsztein

  Source: Nature medicine. 2005 Jun

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• Dynein mutations impair autophagic clearance of aggregate-prone proteins.

  Mutations that affect the dynein motor machinery are sufficient to cause motor neuron disease. It is not known why there are aggregates or inclusions …

  Authors: Brinda Ravikumar, Abraham Acevedo-Arozena, Sara Imarisio, Zdenek Berger, Coralie Vacher, Cahir J O'Kane, Steve D M Brown, David C Rubinsztein

  Source: Nature genetics. 2005 Jul

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• Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.

  Huntington disease is one of nine inherited neurodegenerative disorders caused by a polyglutamine tract expansion. Expanded polyglutamine proteins acc…

  Authors: Brinda Ravikumar, Coralie Vacher, Zdenek Berger, Janet E Davies, Shouqing Luo, Lourdes G Oroz, Francesco Scaravilli, Douglas F Easton, Rainer Duden, Cahir J O'Kane,…

  Source: Nature genetics. 2004 Jun

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• Rapamycin pre-treatment protects against apoptosis.

  Macroautophagy (generally referred to as autophagy) mediates the bulk degradation of cytoplasmic contents, including proteins and organelles, in lysos…

  Authors: Brinda Ravikumar, Zdenek Berger, Coralie Vacher, Cahir J O'Kane, David C Rubinsztein

  Source: Human molecular genetics. 2006 Apr 1

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• Overexpression of yeast hsp104 reduces polyglutamine aggregation and prolongs survival of a transgenic mouse model of Huntington's disease.

  Huntington's disease is a devastating neurodegenerative condition associated with the formation of intraneuronal aggregates by mutant huntingtin. Aggr…

  Authors: Coralie Vacher, Lourdes Garcia-Oroz, David C Rubinsztein

  Source: Human molecular genetics. 2005 Nov 15

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• The bacterial chaperonin GroEL requires GroES to reduce aggregation and cell death in a COS-7 cell model of Huntington's disease.

  Huntington's disease (HD) is caused by expansions of more than 35 CAG repeats in the HD gene. These repeats are translated into a long polyglutamine t…

  Authors: Jenny Carmichael, Coralie Vacher, David C Rubinsztein

  Source: Neuroscience letters. 2002 Sep 27

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• Dopamine D2 receptors and secretion of FSH and LH: role of sexual steroids on the pituitary of the female rainbow trout.

  The role of sexual steroids in the modulation of a dopaminergic inhibitory tone on FSH and LH release was studied in the rainbow trout. The experiment…

  Authors: Coralie Vacher, François Ferrière, Marie-Hélène Marmignon, Elisabeth Pellegrini, Christian Saligaut

  Source: General and comparative endocrinology. 2002 Jun 15

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• Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity.

  Huntington's disease (HD) is a neurodegenerative disorder caused by an expanded polyglutamine (polyQ) tract in the huntingtin (htt) protein. Mutant ht…

  Authors: Shouqing Luo, Coralie Vacher, Janet E Davies, David C Rubinsztein

  Source: The Journal of cell biology. 2005 May 23

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• Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles.

  There has been considerable progress recently towards developing therapeutic strategies for Huntington's disease (HD), with several compounds showing …

  Authors: Benjamin R Underwood, David Broadhurst, Warwick B Dunn, David I Ellis, Andrew W Michell, Coralie Vacher, David E Mosedale, Douglas B Kell, Roger A Barker, David J Grainger,…

  Source: Brain : a journal of neurology. 2006 Apr

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• Distribution of dopamine D2 receptor mRNAs in the brain and the pituitary of female rainbow trout: an in situ hybridization study.

  The distribution of D(2)R (dopamine D(2) receptor) mRNAs was studied in the forebrain of maturing female rainbow trout by means of in situ hybridizati…

  Authors: Coralie Vacher, Elisabeth Pellegrini, Isabelle Anglade, François Ferriére, Christian Saligaut, Olivier Kah

  Source: The Journal of comparative neurology. 2003 Mar 24

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