1 to 10 of 163 literature results

• Alanine-2 carbonyl is an oxygen ligand in Cu2+ coordination of Alzheimer's disease amyloid-beta peptide--relevance to N-terminally truncated forms.

  Copper interactions with the beta-amyloid peptide (Abeta) are believed to play a role in Alzheimer's disease (AD), in particular due to production of …

  Authors: Simon C Drew, Colin L Masters, Kevin J Barnham

  Source: Journal of the American Chemical Society. 2009 Jul 1

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• Delineating common molecular mechanisms in Alzheimer's and prion diseases.

  The structure of the infectious agent responsible for prion diseases has not been fully characterized, but evidence points to a beta-rich conformer of…

  Authors: Kevin J Barnham, Roberto Cappai, Konrad Beyreuther, Colin L Masters, Andrew F Hill

  Source: Trends in biochemical sciences. 2006 Aug

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• Transmissible spongiform encephalopathies.

  Nosologically, transmissible spongiform encephalopathies (TSE or prion diseases) should be grouped with other neurodegenerative disorders such as Alzh…

  Authors: Steven J Collins, Victoria A Lawson, Colin L Masters

  Source: Lancet. 2004 Jan 3

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• Dominant roles of the polybasic proline motif and copper in the PrP23-89-mediated stress protection response.

  Beta-cleavage of the neurodegenerative disease-associated prion protein (PrP) protects cells from death induced by oxidative insults. The beta-cleavag…

  Authors: Cathryn L Haigh, Simon C Drew, Martin P Boland, Colin L Masters, Kevin J Barnham, Victoria A Lawson, Steven J Collins

  Source: Journal of cell science. 2009 May 15

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• Pleomorphic copper coordination by Alzheimer's disease amyloid-beta peptide.

  Numerous conflicting models have been proposed regarding the nature of the Cu(2+) coordination environment of the amyloid beta (Abeta) peptide, the ca…

  Authors: Simon C Drew, Christopher J Noble, Colin L Masters, Graeme R Hanson, Kevin J Barnham

  Source: Journal of the American Chemical Society. 2009 Jan 28

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• Dopamine D2 receptor knockout mice develop features of Parkinson disease.

  OBJECTIVE: This study questions whether increased dopamine (DA) turnover in nigral neurons leads to formation of Lewy bodies (LBs), the characteristic…

  Authors: Rogan B Tinsley, Chris R Bye, Clare L Parish, Angela Tziotis-Vais, Sonia George, Janetta G Culvenor, Qiao-Xin Li, Colin L Masters, David I Finkelstein, Malcolm K Horne

  Source: Annals of neurology. 2009 Oct

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• Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta.

  As a disease-modifying approach for Alzheimer's disease (AD), clioquinol (CQ) targets beta-amyloid (Abeta) reactions with synaptic Zn and Cu yet promo…

  Authors: Paul A Adlard, Robert A Cherny, David I Finkelstein, Elisabeth Gautier, Elysia Robb, Mikhalina Cortes, Irene Volitakis, Xiang Liu, Jeffrey P Smith, Keyla Perez,…

  Source: Neuron. 2008 Jul 10

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• Cu2+ binding modes of recombinant alpha-synuclein--insights from EPR spectroscopy.

  The interaction of the small (140 amino acid) protein, alpha-synuclein (alphaS), with Cu(2+) has been proposed to play a role in Parkinson's disease (…

  Authors: Simon C Drew, Su Ling Leong, Chi L L Pham, Deborah J Tew, Colin L Masters, Luke A Miles, Roberto Cappai, Kevin J Barnham

  Source: Journal of the American Chemical Society. 2008 Jun 18

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• C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1.

  The Parkinson's disease (PD) causative PINK1 gene encodes a mitochondrial protein kinase called PTEN-induced kinase 1 (PINK1). The autosomal recessive…

  Authors: Chou Hung Sim, Daisy Sio Seng Lio, Su San Mok, Colin L Masters, Andrew F Hill, Janetta G Culvenor, Heung-Chin Cheng

  Source: Human molecular genetics. 2006 Nov 1

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• Increased proportions of C1 truncated prion protein protect against cellular M1000 prion infection.

  Prion disease pathogenesis is linked to the cell-associated propagation of misfolded protease-resistant conformers (PrP) of the normal cellular prion …

  Authors: Victoria Lewis, Andrew F Hill, Cathryn L Haigh, Genevieve M Klug, Colin L Masters, Victoria A Lawson, Steven J Collins

  Source: Journal of neuropathology and experimental neurology. 2009 Oct

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