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Genetic model of selective COX2 inhibition reveals novel heterodimer signaling.
Selective inhibitors of cyclooxygenase-2 (COX2) have attracted widespread media attention because of evidence of an elevated risk of cardiovascular co…
Authors: Ying Yu, Jinjin Fan, Xin-Sheng Chen, Dairong Wang, Andres J Klein-Szanto, Robert L Campbell, Garret A FitzGerald, Colin D Funk
Source: Nature medicine. 2006 Jun
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Cyclooxygenase-2-dependent prostacyclin formation and blood pressure homeostasis: targeted exchange of cyclooxygenase isoforms in mice.
RATIONALE: Cyclooxygenase (COX)-derived prostanoids (PGs) are involved in blood pressure homeostasis. Both traditional nonsteroidal antiinflammatory d…
Authors: Ying Yu, Jane Stubbe, Salam Ibrahim, Wen-liang Song, Emer M Symth, Colin D Funk, Garret A FitzGerald
Source: Circulation research. 2010 Feb 5
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Endothelial cysteinyl leukotriene 2 receptor expression and myocardial ischemia/reperfusion injury.
Myocardial infarction with associated reperfusion injury results most commonly from complications of atherothrombosis combined with leukocyte-mediated…
Authors: Michael P W Moos, Colin D Funk
Source: Trends in cardiovascular medicine. 2008 Oct
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The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm.
Activation of the 5-lipoxygenase (5-LO) pathway leads to the biosynthesis of proinflammatory leukotriene lipid mediators. Genetic studies have associa…
Authors: Lei Zhao, Michael P W Moos, Rolf Gräbner, Frédérique Pédrono, Jinjin Fan, Brigitte Kaiser, Nicole John, Sandra Schmidt, Rainer Spanbroek, Katharina Lötzer,…
Source: Nature medicine. 2004 Sep
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A cell-based assay for screening lipoxygenase inhibitors.
Lipoxygenases (LOX) form a family of lipid peroxidizing enzymes within the plant and animal kingdoms. In humans, six functional lipoxygenase isoforms …
Authors: Dileep G Nair, Colin D Funk
Source: Prostaglandins & other lipid mediators. 2009 Dec
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Genetic and pharmacological inhibition of the 5-lipoxygenase/leukotriene pathway in atherosclerotic lesion development in ApoE deficient mice.
The 5-lipoxygenase (5-LO) catalyzed formation of leukotriene (LT) lipid mediators is a pathway contributing to inflammatory events in asthma and more …
Authors: Richard Yang Cao, Tim St Amand, Rolf Gräbner, Andreas J R Habenicht, Colin D Funk
Source: Atherosclerosis. 2009 Apr
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A novel genetic model of selective COX-2 inhibition: comparison with COX-2 null mice.
Prostaglandin H Synthase (PGHS) is a bi-functional enzyme with a cyclooxygenase (COX) activity and a functionally linked peroxidase (POX) activity tha…
Authors: Ying Yu, Colin D Funk
Source: Prostaglandins & other lipid mediators. 2007 Jan
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Directed vascular expression of human cysteinyl leukotriene 2 receptor modulates endothelial permeability and systemic blood pressure.
BACKGROUND: The proinflammatory and vascular actions of cysteinyl leukotrienes (CysLTs) are mediated by 2 receptors: cysteinyl leukotriene 1 receptor …
Authors: Yiqun Hui, Yan Cheng, Isabella Smalera, Wenying Jian, Lawrence Goldhahn, Garret A Fitzgerald, Colin D Funk
Source: Circulation. 2004 Nov 23
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Lipoxygenase pathways in atherogenesis.
15-lipoxygenase-1 (also known as 12/15-LO in mice) and 5-LO/5-LO-activating protein (FLAP) cascades play central roles in low-density lipoprotein oxid…
Authors: Lei Zhao, Colin D Funk
Source: Trends in cardiovascular medicine. 2004 Jul
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Angiotensin II-induced abdominal aortic aneurysm occurs independently of the 5-lipoxygenase pathway in apolipoprotein E-deficient mice.
Genetic association studies and pathological analysis of cardiovascular disease specimens implicate a role for the 5-lipoxygenase (5-LO)/leukotriene (…
Authors: Richard Yang Cao, Michael A Adams, Andreas J Habenicht, Colin D Funk
Source: Prostaglandins & other lipid mediators. 2007 Aug
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