Click on one of these terms to refine your search
1 to 10 of 47 literature results
Selective inhibitors of cyclooxygenase-2 (COX2) have attracted widespread media attention because of evidence of an elevated risk of cardiovascular co…
Authors: Ying Yu, Jinjin Fan, Xin-Sheng Chen, Dairong Wang, Andres J Klein-Szanto, Robert L Campbell, Garret A FitzGerald, Colin D Funk
Source: Nature medicine. 2006 Jun
View Full TextRATIONALE: Cyclooxygenase (COX)-derived prostanoids (PGs) are involved in blood pressure homeostasis. Both traditional nonsteroidal antiinflammatory d…
Authors: Ying Yu, Jane Stubbe, Salam Ibrahim, Wen-liang Song, Emer M Symth, Colin D Funk, Garret A FitzGerald
Source: Circulation research. 2010 Feb 5
View Full TextMyocardial infarction with associated reperfusion injury results most commonly from complications of atherothrombosis combined with leukocyte-mediated…
Authors: Michael P W Moos, Colin D Funk
Source: Trends in cardiovascular medicine. 2008 Oct
View Full TextActivation of the 5-lipoxygenase (5-LO) pathway leads to the biosynthesis of proinflammatory leukotriene lipid mediators. Genetic studies have associa…
Authors: Lei Zhao, Michael P W Moos, Rolf Gräbner, Frédérique Pédrono, Jinjin Fan, Brigitte Kaiser, Nicole John, Sandra Schmidt, Rainer Spanbroek, Katharina Lötzer,…
Source: Nature medicine. 2004 Sep
View Full TextLipoxygenases (LOX) form a family of lipid peroxidizing enzymes within the plant and animal kingdoms. In humans, six functional lipoxygenase isoforms …
Authors: Dileep G Nair, Colin D Funk
Source: Prostaglandins & other lipid mediators. 2009 Dec
View Full TextThe 5-lipoxygenase (5-LO) catalyzed formation of leukotriene (LT) lipid mediators is a pathway contributing to inflammatory events in asthma and more …
Authors: Richard Yang Cao, Tim St Amand, Rolf Gräbner, Andreas J R Habenicht, Colin D Funk
Source: Atherosclerosis. 2009 Apr
View Full TextProstaglandin H Synthase (PGHS) is a bi-functional enzyme with a cyclooxygenase (COX) activity and a functionally linked peroxidase (POX) activity tha…
Authors: Ying Yu, Colin D Funk
Source: Prostaglandins & other lipid mediators. 2007 Jan
View Full TextBACKGROUND: The proinflammatory and vascular actions of cysteinyl leukotrienes (CysLTs) are mediated by 2 receptors: cysteinyl leukotriene 1 receptor …
Authors: Yiqun Hui, Yan Cheng, Isabella Smalera, Wenying Jian, Lawrence Goldhahn, Garret A Fitzgerald, Colin D Funk
Source: Circulation. 2004 Nov 23
View Full Text15-lipoxygenase-1 (also known as 12/15-LO in mice) and 5-LO/5-LO-activating protein (FLAP) cascades play central roles in low-density lipoprotein oxid…
Authors: Lei Zhao, Colin D Funk
Source: Trends in cardiovascular medicine. 2004 Jul
View Full TextGenetic association studies and pathological analysis of cardiovascular disease specimens implicate a role for the 5-lipoxygenase (5-LO)/leukotriene (…
Authors: Richard Yang Cao, Michael A Adams, Andreas J Habenicht, Colin D Funk
Source: Prostaglandins & other lipid mediators. 2007 Aug
View Full Text