1 to 10 of 56 literature results

• Stem-cell therapies for blood diseases.

  For decades, transplantation of haematopoietic stem cells--either unmodified, or genetically modified to correct genetic disorders--has been used to t…

  Authors: Claudio Bordignon

  Source: Nature. 2006 Jun 29

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• Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses.

  Sterol metabolism has recently been linked to innate and adaptive immune responses through liver X receptor (LXR) signaling. Whether products of stero…

  Authors: Eduardo J Villablanca, Laura Raccosta, Dan Zhou, Raffaella Fontana, Daniela Maggioni, Aurora Negro, Francesca Sanvito, Maurilio Ponzoni, Barbara Valentinis, Marco Bregni,…

  Source: Nature medicine. 2010 Jan

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• Mesoangioblast stem cells ameliorate muscle function in dystrophic dogs.

  Duchenne muscular dystrophy remains an untreatable genetic disease that severely limits motility and life expectancy in affected children. The only an…

  Authors: Maurilio Sampaolesi, Stephane Blot, Giuseppe D'Antona, Nicolas Granger, Rossana Tonlorenzi, Anna Innocenzi, Paolo Mognol, Jean-Lauren Thibaud, Beatriz G Galvez, Ines Barthélémy,…

  Source: Nature. 2006 Nov 30

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• Peripheral blood lymphocytes genetically modified to express the self/tumor antigen MAGE-A3 induce antitumor immune responses in cancer patients.

  Dendritic cell (DC) targeting in vivo has recently been shown to confer strong and protective cytotoxic T lymphocyte (CTL)-based immunity in tumor mur…

  Authors: Raffaella Fontana, Marco Bregni, Arcadi Cipponi, Laura Raccosta, Cristina Rainelli, Daniela Maggioni, Francesca Lunghi, Fabio Ciceri, Sylvain Mukenge, Claudio Doglioni,…

  Source: Blood. 2009 Feb 19

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• Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients.

  Mutations in the adenosine deaminase (ADA) gene are responsible for a form of severe combined immunodeficiency (SCID) caused by the lymphotoxic accumu…

  Authors: Barbara Cassani, Massimiliano Mirolo, Federica Cattaneo, Ulrike Benninghoff, Michael Hershfield, Filippo Carlucci, Antonella Tabucchi, Claudio Bordignon, Maria Grazia Roncarolo, Alessandro Aiuti

  Source: Blood. 2008 Apr 15

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• The potential immunogenicity of the TK suicide gene does not prevent full clinical benefit associated with the use of TK-transduced donor lymphocytes in HSCT for hematologic malignancies.

  Gene therapy is a promising therapeutic strategy for genetic and acquired hematologic diseases. With the improvements in gene transfer and expression,…

  Authors: Catia Traversari, Sarah Marktel, Zulma Magnani, Patrizia Mangia, Vincenzo Russo, Fabio Ciceri, Chiara Bonini, Claudio Bordignon

  Source: Blood. 2007 Jun 1

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• NGR and isoDGR are separate moieties binding to different receptors.

  Authors: Gian-Paolo Rizzardi, Claudio Bordignon

  Source: Blood. 2009 May 21

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• IL-7 and IL-15 allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes.

  Long-term clinical remissions of leukemia, after allogeneic hematopoietic stem cell transplantation, depend on alloreactive memory T cells able to sel…

  Authors: Shin Kaneko, Sara Mastaglio, Attilio Bondanza, Maurilio Ponzoni, Francesca Sanvito, Luca Aldrighetti, Marina Radrizzani, Simona La Seta-Catamancio, Elena Provasi, Anna Mondino,…

  Source: Blood. 2009 Jan 29

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• Unplugging the T cell receptor.

  Authors: Guido Poli, Claudio Bordignon

  Source: Nature immunology. 2003 Oct

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• Isoaspartate-glycine-arginine: a new tumor vasculature-targeting motif.

  Asparagine deamidation in peptides or in fibronectin fragments containing the asparagine-glycine-arginine sequence generates isoaspartate-glycine-argi…

  Authors: Flavio Curnis, Angelina Sacchi, Anna Gasparri, Renato Longhi, Angela Bachi, Claudio Doglioni, Claudio Bordignon, Catia Traversari, Gian-Paolo Rizzardi, Angelo Corti

  Source: Cancer research. 2008 Sep 1

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