1 to 10 of 15 literature results

• Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells.

  Self-renewing cell populations such as hematopoietic stem cells and memory B and T lymphocytes might be regulated by shared signaling pathways. The Wn…

  Authors: Luca Gattinoni, Xiao-Song Zhong, Douglas C Palmer, Yun Ji, Christian S Hinrichs, Zhiya Yu, Claudia Wrzesinski, Andrea Boni, Lydie Cassard, Lindsay M Garvin,…

  Source: Nature medicine. 2009 Jul

  View Free Full Text

• Less is more: lymphodepletion followed by hematopoietic stem cell transplant augments adoptive T-cell-based anti-tumor immunotherapy.

  Adoptive T-cell immunotherapy combined with non-myeloablative lymphodepletion has emerged as the most effective immunotherapy treatment for patients w…

  Authors: Claudia Wrzesinski, Nicholas P Restifo

  Source: Current opinion in immunology. 2005 Apr

  View Free Full Text

• Type 17 CD8+ T cells display enhanced antitumor immunity.

  Interleukin-17 (IL-17)-secreting CD8(+) T cells have been described, but they have not been thoroughly studied and they do not have a known role in ca…

  Authors: Christian S Hinrichs, Andrew Kaiser, Chrystal M Paulos, Lydie Cassard, Luis Sanchez-Perez, Bianca Heemskerk, Claudia Wrzesinski, Zachary A Borman, Pawel Muranski, Nicholas P Restifo

  Source: Blood. 2009 Jul 16

  View Full Text

• Adoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers.

  Graft-versus-tumor effects can be achieved after allogeneic bone marrow transplantation in patients with malignancies of the kidney or hematopoietic s…

  Authors: Andrea Boni, Pawel Muranski, Lydie Cassard, Claudia Wrzesinski, Chrystal M Paulos, Douglas C Palmer, Luca Gattinoni, Christian S Hinrichs, Chi-Chao Chan, Steven A Rosenberg,…

  Source: Blood. 2008 Dec 1

  View Free Full Text

• Tumor-specific Th17-polarized cells eradicate large established melanoma.

  CD4+ T cells can differentiate into multiple effector subsets, but the potential roles of these subsets in anti-tumor immunity have not been fully exp…

  Authors: Pawel Muranski, Andrea Boni, Paul A Antony, Lydie Cassard, Kari R Irvine, Andrew Kaiser, Chrystal M Paulos, Douglas C Palmer, Christopher E Touloukian, Krzysztof Ptak,…

  Source: Blood. 2008 Jul 15

  View Free Full Text

• Chimeric and pseudotyped parvoviruses minimize the contamination of recombinant stocks with replication-competent viruses and identify a DNA sequence that restricts parvovirus H-1 in mouse cells.

  Recent studies demonstrated the ability of the recombinant autonomous parvoviruses MVMp (fibrotropic variant of the minute virus of mice) and H-1 to t…

  Authors: Claudia Wrzesinski, Lia Tesfay, Nathalie Salomé, Jean-Claude Jauniaux, Jean Rommelaere, Jan Cornelis, Christiane Dinsart

  Source: Journal of virology. 2003 Mar

  View Free Full Text

• Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells.

  Lymphodepletion before adoptive cell transfer (ACT)-based immunotherapies can enhance anti-tumor responses by augmenting innate immunity, by increasin…

  Authors: Claudia Wrzesinski, Chrystal M Paulos, Andrew Kaiser, Pawel Muranski, Douglas C Palmer, Luca Gattinoni, Zhiya Yu, Steven A Rosenberg, Nicholas P Restifo

  Source: Journal of immunotherapy (Hagerstown, Md. : 1997). 2010 Jan

  View Full Text

• Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8 T cells.

  Depleting host immune elements with nonmyeloablative regimens prior to the adoptive transfer of tumor-specific CD8(+) T cells significantly enhances t…

  Authors: Claudia Wrzesinski, Chrystal M Paulos, Luca Gattinoni, Douglas C Palmer, Andrew Kaiser, Zhiya Yu, Steven A Rosenberg, Nicholas P Restifo

  Source: The Journal of clinical investigation. 2007 Feb

  View Free Full Text

• Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity.

  Nonmutated tissue differentiation antigens expressed by tumors are attractive targets for cancer immunotherapy, but the consequences of a highly effec…

  Authors: Douglas C Palmer, Chi-Chao Chan, Luca Gattinoni, Claudia Wrzesinski, Chrystal M Paulos, Christian S Hinrichs, Daniel J Powell, Christopher A Klebanoff, Steven E Finkelstein, Robert N Fariss,…

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2008 Jun 10

  View Free Full Text

• Increased intensity lymphodepletion and adoptive immunotherapy--how far can we go?

  In a recent clinical trial involving patients with metastatic melanoma, immunosuppressive conditioning with fludarabine and cyclophosphamide resulted …

  Authors: Pawel Muranski, Andrea Boni, Claudia Wrzesinski, Deborah E Citrin, Steven A Rosenberg, Richard Childs, Nicholas P Restifo

  Source: Nature clinical practice. Oncology. 2006 Dec

  View Free Full Text