1 to 10 of 25 literature results

• Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation.

  Defining critical points of modulation across heterogeneous clinical syndromes may provide insight into new therapeutic approaches. Coagulation initia…

  Authors: Frank Niessen, Florence Schaffner, Christian Furlan-Freguia, Rafal Pawlinski, Gourab Bhattacharjee, Jerold Chun, Claudia K Derian, Patricia Andrade-Gordon, Hugh Rosen, Wolfram Ruf

  Source: Nature. 2008 Apr 3

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• Blocking the protease-activated receptor 1-4 heterodimer in platelet-mediated thrombosis.

  BACKGROUND: Thrombin is the most potent agonist of platelets and plays a critical role in the development of arterial thrombosis. Human platelets expr…

  Authors: Andrew J Leger, Suzanne L Jacques, Jehangir Badar, Nicole C Kaneider, Claudia K Derian, Patricia Andrade-Gordon, Lidija Covic, Athan Kuliopulos

  Source: Circulation. 2006 Mar 7

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• Novel bis(indolyl)maleimide pyridinophanes that are potent, selective inhibitors of glycogen synthase kinase-3.

  Novel bis(indolyl)maleimide pyridinophanes 3, 9a, 9b, 10a, 10b, and 11 were prepared by cobalt-mediated [2+2+2] cycloaddition of an appropriate alpha,…

  Authors: Han-Cheng Zhang, Llorente V R Boñaga, Hong Ye, Claudia K Derian, Bruce P Damiano, Bruce E Maryanoff

  Source: Bioorganic & medicinal chemistry letters. 2007 May 15

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• Functional informatics: convergence and integration of automation and bioinformatics.

  The biopharmaceutical industry is currently being presented with opportunities to improve research and business efficiency via automation and the inte…

  Authors: Sergey E Ilyin, Alejandro Bernal, Daniel Horowitz, Claudia K Derian, Hong Xin

  Source: Pharmacogenomics. 2004 Sep

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• Therapeutic potential of protease-activated receptor-1 antagonists.

  The serine protease thrombin (EC 3.4.21.5) is central to the maintenance of haemostatic balance through its coagulant, anticoagulant and platelet acti…

  Authors: Claudia K Derian, Bruce E Maryanoff, Han-Cheng Zhang, Patricia Andrade-Gordon

  Source: Expert opinion on investigational drugs. 2003 Feb

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• Novel indolylindazolylmaleimides as inhibitors of protein kinase C-beta: synthesis, biological activity, and cardiovascular safety.

  Novel indolylindazolylmaleimides were synthesized and examined for kinase inhibition. We identified low-nanomolar inhibitors of PKC-beta with good to …

  Authors: Han-Cheng Zhang, Claudia K Derian, David F McComsey, Kimberly B White, Hong Ye, Leonard R Hecker, Jian Li, Michael F Addo, Diane Croll, Annette J Eckardt,…

  Source: Journal of medicinal chemistry. 2005 Mar 24

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• An assay for sphingosine kinase activity using biotinylated sphingosine and streptavidin-coated membranes.

  Sphingosine kinase catalyses the phosphorylation of sphingosine to generate sphingosine 1-phosphate, a lipid signaling molecule implicated in roles in…

  Authors: Jane L Roberts, Paul A B Moretti, Andrew L Darrow, Claudia K Derian, Mathew A Vadas, Stuart M Pitson

  Source: Analytical biochemistry. 2004 Aug 1

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• RWJ-58259: a selective antagonist of protease activated receptor-1.

  Protease activated receptor-1 (PAR-1) is a key mediator of the cellular actions of alpha-thrombin. Thus, antagonism of this unique G-protein coupled r…

  Authors: Bruce P Damiano, Claudia K Derian, Bruce E Maryanoff, Han-Cheng Zhang, Patricia Andrade Gordon

  Source: Cardiovascular drug reviews. 2003

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• High-affinity thrombin receptor (PAR-1) ligands: a new generation of indole-based peptide mimetic antagonists with a basic amine at the C-terminus.

  A new generation of indole-based peptide mimetics, bearing a basic amine at the C-terminus, was developed by the agency of two complementary, multiste…

  Authors: Han Cheng Zhang, Kimberly B White, David F McComsey, Michael F Addo, Patricia Andrade-Gordon, Claudia K Derian, Donna Oksenberg, Bruce E Maryanoff

  Source: Bioorganic & medicinal chemistry letters. 2003 Jul 7

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• 3-(7-Azaindolyl)-4-arylmaleimides as potent, selective inhibitors of glycogen synthase kinase-3.

  A novel series of acyclic 3-(7-azaindolyl)-4-(aryl/heteroaryl)maleimides was synthesized and evaluated for activity against GSK-3beta and selectivity …

  Authors: Han-Cheng Zhang, Hong Ye, Bruce R Conway, Claudia K Derian, Michael F Addo, Gee-Hong Kuo, Leonard R Hecker, Diane R Croll, Jian Li, Lori Westover,…

  Source: Bioorganic & medicinal chemistry letters. 2004 Jun 21

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