1 to 10 of 61 literature results

• Multistep pathogenesis of autoimmune disease.

  In the immune system, many tolerance checkpoints exist to prevent self-antigens from stimulating the relentless growth of self-reactive B and T lympho…

  Authors: Christopher C Goodnow

  Source: Cell. 2007 Jul 13

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• Two levels of protection for the B cell genome during somatic hypermutation.

  Somatic hypermutation introduces point mutations into immunoglobulin genes in germinal centre B cells during an immune response. The reaction is initi…

  Authors: Man Liu, Jamie L Duke, Daniel J Richter, Carola G Vinuesa, Christopher C Goodnow, Steven H Kleinstein, David G Schatz

  Source: Nature. 2008 Feb 14

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• Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection.

  T cell antigen receptor (TCR) signaling in CD4(+)CD8(+) double-positive thymocytes determines cell survival and lineage commitment, but the genetic an…

  Authors: Andy L Johnson, L Aravind, Natalia Shulzhenko, Andre Morgun, See-Young Choi, Tanya L Crockford, Teresa Lambe, Heather Domaschenz, Edyta M Kucharska, Lixin Zheng,…

  Source: Nature immunology. 2009 Aug

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• Cellular and genetic mechanisms of self tolerance and autoimmunity.

  The mammalian immune system has an extraordinary potential for making receptors that sense and neutralize any chemical entity entering the body. Inevi…

  Authors: Christopher C Goodnow, Jonathon Sprent, Barbara Fazekas de St Groth, Carola G Vinuesa

  Source: Nature. 2005 Jun 2

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• The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency.

  Mice carrying the recessive locus for peripheral T cell deficiency (Ptcd) have a block in thymic egress, but the mechanism responsible is undefined. H…

  Authors: Lawrence R Shiow, David W Roadcap, Kenneth Paris, Susan R Watson, Irina L Grigorova, Tonya Lebet, Jinping An, Ying Xu, Craig N Jenne, Niko Föger,…

  Source: Nature immunology. 2008 Nov

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• Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA.

  Immune responses are normally targeted against microbial pathogens and not self-antigens by mechanisms that are only partly understood. Here we define…

  Authors: Di Yu, Andy Hee-Meng Tan, Xin Hu, Vicki Athanasopoulos, Nicholas Simpson, Diego G Silva, Andreas Hutloff, Keith M Giles, Peter J Leedman, Kong Peng Lam,…

  Source: Nature. 2007 Nov 8

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• Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.

  To identify genes and mechanisms involved in humoral immunity, we did a mouse genetic screen for mutations that do not affect the first wave of antibo…

  Authors: Katrina L Randall, Teresa Lambe, Andy Johnson, Bebhinn Treanor, Edyta Kucharska, Heather Domaschenz, Belinda Whittle, Lina E Tze, Anselm Enders, Tanya L Crockford,…

  Source: Nature immunology. 2009 Dec

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• DNA repair is limiting for haematopoietic stem cells during ageing.

  Accumulation of DNA damage leading to adult stem cell exhaustion has been proposed to be a principal mechanism of ageing. Here we address this questio…

  Authors: Anastasia Nijnik, Lisa Woodbine, Caterina Marchetti, Sara Dawson, Teresa Lambe, Cong Liu, Neil P Rodrigues, Tanya L Crockford, Erik Cabuy, Alessandro Vindigni,…

  Source: Nature. 2007 Jun 7

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• Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling.

  Lymphocyte antigen receptors are responsible for inducing the opposite responses of immunity or tolerance. How the correct polarity of antigen recepto…

  Authors: Jesse E Jun, Christopher C Goodnow

  Source: Nature immunology. 2003 Nov

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• Burst-enhancing role of the IgG membrane tail as a molecular determinant of memory.

  The basis of immune memory leading to heightened secondary antibody responses is a longstanding unanswered issue. Here we show that a single irreversi…

  Authors: Stephen W Martin, Christopher C Goodnow

  Source: Nature immunology. 2002 Feb

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