1 to 4 of 4 literature results

• An inactivating mutation in HDAC2 leads to dysregulation of apoptosis mediated by APAF1.

  BACKGROUND & AIMS: Histone deacetylases (HDACs) are important regulators of chromatin involved in silencing tumor suppressor genes. We examined mutati…

  Authors: Christin L Hanigan, Manon Van Engeland, Adriaan P De Bruine, Kim A Wouters, Matty P Weijenberg, James R Eshleman, James G Herman

  Source: Gastroenterology. 2008 Nov

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• Role for DNA methylation in the control of cell type specific maspin expression.

  The nucleotide 5-methylcytosine is involved in processes crucial in mammalian development, such as X-chromosome inactivation and gene imprinting. In a…

  Authors: Bernard W Futscher, Marc M Oshiro, Ryan J Wozniak, Nicholas Holtan, Christin L Hanigan, Hong Duan, Frederick E Domann

  Source: Nature genetics. 2002 Jun

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• Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53.

  Loss of p53 function by inactivating mutations results in abrogation of NO*induced apoptosis in human lymphoblastoid cells. Here we report characteriz…

  Authors: Chun-Qi Li, Ana I Robles, Christin L Hanigan, Lorne J Hofseth, Laura J Trudel, Curtis C Harris, Gerald N Wogan

  Source: Cancer research. 2004 May 1

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• Schedule-dependent synergy between the heat shock protein 90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin and doxorubicin restores apoptosis to p53-mutant lymphoma cell lines.

  PURPOSE: Loss of p53 function impairs apoptosis induced by DNA-damaging agents used for cancer therapy. Here, we examined the effect of the heat shock…

  Authors: Ana I Robles, Mollie H Wright, Bheru Gandhi, Steven S Feis, Christin L Hanigan, Adrian Wiestner, Lyuba Varticovski

  Source: Clinical cancer research : an official journal of the American Association for Cancer Research. 2006 Nov 1

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