1 to 10 of 17 literature results

• Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells.

  Self-renewing cell populations such as hematopoietic stem cells and memory B and T lymphocytes might be regulated by shared signaling pathways. The Wn…

  Authors: Luca Gattinoni, Xiao-Song Zhong, Douglas C Palmer, Yun Ji, Christian S Hinrichs, Zhiya Yu, Claudia Wrzesinski, Andrea Boni, Lydie Cassard, Lindsay M Garvin,…

  Source: Nature medicine. 2009 Jul

  View Free Full Text

• Programming CD8+ T cells for effective immunotherapy.

  The differentiation state of CD8+ T cells has emerged as a crucial determinant of their ability to respond to tumor and infection. Signals from T-cell…

  Authors: Christian S Hinrichs, Luca Gattinoni, Nicholas P Restifo

  Source: Current opinion in immunology. 2006 Jun

  View Free Full Text

• Type 17 CD8+ T cells display enhanced antitumor immunity.

  Interleukin-17 (IL-17)-secreting CD8(+) T cells have been described, but they have not been thoroughly studied and they do not have a known role in ca…

  Authors: Christian S Hinrichs, Andrew Kaiser, Chrystal M Paulos, Lydie Cassard, Luis Sanchez-Perez, Bianca Heemskerk, Claudia Wrzesinski, Zachary A Borman, Pawel Muranski, Nicholas P Restifo

  Source: Blood. 2009 Jul 16

  View Full Text

• IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy.

  IL-2 and IL-21 are closely related cytokines that might have arisen by gene duplication. Both cytokines promote the function of effector CD8(+) T cell…

  Authors: Christian S Hinrichs, Rosanne Spolski, Chrystal M Paulos, Luca Gattinoni, Keith W Kerstann, Douglas C Palmer, Christopher A Klebanoff, Steven A Rosenberg, Warren J Leonard, Nicholas P Restifo

  Source: Blood. 2008 Jun 1

  View Free Full Text

• Adoptive transfer of allogeneic tumor-specific T cells mediates effective regression of large tumors across major histocompatibility barriers.

  Graft-versus-tumor effects can be achieved after allogeneic bone marrow transplantation in patients with malignancies of the kidney or hematopoietic s…

  Authors: Andrea Boni, Pawel Muranski, Lydie Cassard, Claudia Wrzesinski, Chrystal M Paulos, Douglas C Palmer, Luca Gattinoni, Christian S Hinrichs, Chi-Chao Chan, Steven A Rosenberg,…

  Source: Blood. 2008 Dec 1

  View Free Full Text

• Tumor-specific Th17-polarized cells eradicate large established melanoma.

  CD4+ T cells can differentiate into multiple effector subsets, but the potential roles of these subsets in anti-tumor immunity have not been fully exp…

  Authors: Pawel Muranski, Andrea Boni, Paul A Antony, Lydie Cassard, Kari R Irvine, Andrew Kaiser, Chrystal M Paulos, Douglas C Palmer, Christopher E Touloukian, Krzysztof Ptak,…

  Source: Blood. 2008 Jul 15

  View Free Full Text

• Lymphedema secondary to postmastectomy radiation: incidence and risk factors.

  BACKGROUND: Postmastectomy radiotherapy (PMRT) has proven benefits for certain patients with breast cancer; however, one of its complications is lymph…

  Authors: Christian S Hinrichs, Nancy L Watroba, Hamed Rezaishiraz, William Giese, Thelma Hurd, Kathleen A Fassl, Stephen B Edge

  Source: Annals of surgical oncology. 2004 Jun

  View Full Text

• Bedside to bench and back again: how animal models are guiding the development of new immunotherapies for cancer.

  Immunotherapy using adoptive cell transfer is a promising approach that can result in the regression of bulky, invasive cancer in some patients. Howev…

  Authors: Steven E Finkelstein, David M Heimann, Christopher A Klebanoff, Paul A Antony, Luca Gattinoni, Christian S Hinrichs, Leroy N Hwang, Douglas C Palmer, Paul J Spiess, Deborah R Surman,…

  Source: Journal of leukocyte biology. 2004 Aug

  View Free Full Text

• The effectiveness of complete decongestive physiotherapy for the treatment of lymphedema following groin dissection for melanoma.

  OBJECTIVE: Groin dissection is performed for the treatment of melanoma and other malignancies. Lymphedema rates as high as 47% have been reported. In …

  Authors: Christian S Hinrichs, John F Gibbs, Deborah Driscoll, James L Kepner, Neal W Wilkinson, Stephen B Edge, Kathleen A Fassl, Robin Muir, William G Kraybill

  Source: Journal of surgical oncology. 2004 Mar 15

  View Full Text

• Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity.

  Nonmutated tissue differentiation antigens expressed by tumors are attractive targets for cancer immunotherapy, but the consequences of a highly effec…

  Authors: Douglas C Palmer, Chi-Chao Chan, Luca Gattinoni, Claudia Wrzesinski, Chrystal M Paulos, Christian S Hinrichs, Daniel J Powell, Christopher A Klebanoff, Steven E Finkelstein, Robert N Fariss,…

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2008 Jun 10

  View Free Full Text