1 to 10 of 66 literature results

• Enhancing immunity through autophagy.

  Next to the proteasome, autophagy is the main catabolic pathway for the degradation of cytoplasmic constituents. The immune system uses it both as an …

  Authors: Christian Münz

  Source: Annual review of immunology. 2009

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• Antigen processing via autophagy--not only for MHC class II presentation anymore?

  T cells monitor intracellular and extracellular protein composition via proteolytic products that are displayed to them on major histocompatibility co…

  Authors: Christian Münz

  Source: Current opinion in immunology. 2010 Feb

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• EBV in MS: guilty by association?

  Epstein-Barr Virus (EBV) is one of the most successful human viruses, infecting more than 90% of the adult population worldwide and persisting for the…

  Authors: Jan D Lünemann, Christian Münz

  Source: Trends in immunology. 2009 Jun

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• Innate and adaptive immunity through autophagy.

  The two main proteolytic machineries of eukaryotic cells, lysosomes and proteasomes, receive substrates by different routes. Polyubiquitination target…

  Authors: Dorothee Schmid, Christian Münz

  Source: Immunity. 2007 Jul

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• Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes.

  Major histocompatibility complex (MHC) class II molecules present products of lysosomal proteolysis to CD4(+) T cells. Although extracellular antigen …

  Authors: Dorothee Schmid, Marc Pypaert, Christian Münz

  Source: Immunity. 2007 Jan

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• Non-cytotoxic protection by human NK cells in mucosal secondary lymphoid tissues.

  Even though NK cells have been named for their spontaneous cytotoxicity, a large subpopulation of human NK cells primarily responds to activation with…

  Authors: Christian Münz

  Source: European journal of immunology. 2008 Nov

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• Immune escape by Epstein-Barr virus associated malignancies.

  Persistent Epstein-Barr virus (EBV) infection remains asymptomatic in the majority of virus carriers, despite the potent growth transforming potential…

  Authors: Christian Münz, Ann Moormann

  Source: Seminars in cancer biology. 2008 Dec

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• Distinct memory CD4+ T-cell subsets mediate immune recognition of Epstein Barr virus nuclear antigen 1 in healthy virus carriers.

  CD4+ T cells, specific for transforming latent infection with the Epstein Barr virus (EBV), consistently recognize the nuclear antigen 1 of EBV (EBNA1…

  Authors: Kevin N Heller, Jenica Upshaw, Beza Seyoum, Henry Zebroski, Christian Münz

  Source: Blood. 2007 Feb 1

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• Autophagy and antigen presentation.

  CD4(+) T cells co-ordinate adaptive immunity and are required for immunological memory establishment and maintenance. They are thought to primarily re…

  Authors: Christian Münz

  Source: Cellular microbiology. 2006 Jun

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• Targeting the nuclear antigen 1 of Epstein-Barr virus to the human endocytic receptor DEC-205 stimulates protective T-cell responses.

  Dendritic cells (DCs) express many endocytic receptors that deliver antigens for major histocompatibility class (MHC) I and II presentation to CD8(+) …

  Authors: Cagan Gurer, Till Strowig, Fabienne Brilot, Maggi Pack, Christine Trumpfheller, Frida Arrey, Chae Gyu Park, Ralph M Steinman, Christian Münz

  Source: Blood. 2008 Aug 15

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