10 literature results

• Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands.

  CONTEXT: People meeting diagnostic criteria for anxiety or depressive disorders tend to score high on the personality scale of neuroticism. Studying t…

  Authors: Naomi R Wray, Christel M Middeldorp, Andrew J Birley, Scott D Gordon, Patrick F Sullivan, Peter M Visscher, Dale R Nyholt, Gonneke Willemsen, Eco J C de Geus, P Eline Slagboom,…

  Source: Archives of general psychiatry. 2008 Jun

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• A twin-family study of the association between employment, burnout and anxious depression.

  BACKGROUND: Earlier studies have shown that employment and burnout are related to anxiety and depression. This twin-family study investigates to what …

  Authors: Christel M Middeldorp, Danielle C Cath, Dorret I Boomsma

  Source: Journal of affective disorders. 2006 Feb

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• Heritability of self-reported phobic fear.

  Twin studies on fear and phobia suggest moderate genetic effects. However, results are inconclusive regarding the presence of dominant genetic effects…

  Authors: Marijn A Distel, Jacqueline M Vink, Gonneke Willemsen, Christel M Middeldorp, Harald L G J Merckelbach, Dorret I Boomsma

  Source: Behavior genetics. 2008 Jan

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• Family based association analyses between the serotonin transporter gene polymorphism (5-HTTLPR) and neuroticism, anxiety and depression.

  We studied the association between the short/long promotor-based length polymorphism of the serotonin transporter gene (5-HTTLPR) and neuroticism, anx…

  Authors: Christel M Middeldorp, Eco J C de Geus, A Leo Beem, Nico Lakenberg, Jouke-Jan Hottenga, P Eline Slagboom, Dorret I Boomsma

  Source: Behavior genetics. 2007 Mar

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• An association between Epac-1 gene variants and anxiety and depression in two independent samples.

  Deficiency in signal transduction might play a role in the development of anxiety and depression, as suggested by a study on the involvement of the PK…

  Authors: Christel M Middeldorp, Jacqueline M Vink, John M Hettema, Eco J C de Geus, Kenneth S Kendler, Gonneke Willemsen, Michael C Neale, Dorret I Boomsma, Xiangning Chen

  Source: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2010 Jan 5

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• Suggestive linkage on chromosome 2, 8, and 17 for lifetime major depression.

  It is well established that major depressive disorder (MDD) is partly heritable. We present a genome-wide linkage study aiming to find regions on the …

  Authors: Christel M Middeldorp, Patrick F Sullivan, Naomi R Wray, Jouke-Jan Hottenga, Eco J C de Geus, Mireille van den Berg, Grant W Montgomery, Will L Coventry, Dixie J Statham, Gavin Andrews,…

  Source: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2009 Apr 5

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• Estimating non-response bias in family studies: application to mental health and lifestyle.

  Non-response to mailed surveys reduces the effective sample size and may introduce bias. Non-response has been studied by (1) comparison to available …

  Authors: Jacqueline M Vink, Gonneke Willemsen, Janine H Stubbe, Christel M Middeldorp, Rozemarijn S L Ligthart, Kim D Baas, Hanneke J C Dirkzwager, Eco J C de Geus, Dorret I Boomsma

  Source: European journal of epidemiology. 2004

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• Sex differences in symptoms of depression in unrelated individuals and opposite-sex twin and sibling pairs.

  Diagnosis of a major depressive episode by the Diagnostic and Statistical Manual of Mental Disorders of the American Psychiatric Association requires …

  Authors: Christel M Middeldorp, Naomi R Wray, Gavin Andrews, Nicholas G Martin, Dorret I Boomsma

  Source: Twin research and human genetics : the official journal of the International Society for Twin Studies. 2006 Oct

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• Twin and genetic effects on life events.

  Twin studies that examine the effect of specific environmental risk factors on psychiatric disorders assume that there are no differences in prevalenc…

  Authors: Christel M Middeldorp, Danielle C Cath, Jacqueline M Vink, Dorret I Boomsma

  Source: Twin research and human genetics : the official journal of the International Society for Twin Studies. 2005 Jun

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• Familial clustering of major depression and anxiety disorders in Australian and Dutch twins and siblings.

  The aim of this study was to investigate familial influences and their dependence on sex for panic disorder and/or agoraphobia, social phobia, general…

  Authors: Christel M Middeldorp, Andrew J Birley, Danielle C Cath, Nathan A Gillespie, Gonneke Willemsen, Dixie J Statham, Eco J C de Geus, J Gavin Andrews, Richard van Dyck, A Leo Beem,…

  Source: Twin research and human genetics : the official journal of the International Society for Twin Studies. 2005 Dec

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