1 to 10 of 52 literature results

• Biosynthesis and assembly of capsular polysaccharides in Escherichia coli.

  Capsules are protective structures on the surfaces of many bacteria. The remarkable structural diversity in capsular polysaccharides is illustrated by…

  Authors: Chris Whitfield

  Source: Annual review of biochemistry. 2006

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• Wza the translocon for E. coli capsular polysaccharides defines a new class of membrane protein.

  Many types of bacteria produce extracellular polysaccharides (EPSs). Some are secreted polymers and show only limited association with the cell surfac…

  Authors: Changjiang Dong, Konstantinos Beis, Jutta Nesper, Anne L Brunkan-Lamontagne, Bradley R Clarke, Chris Whitfield, James H Naismith

  Source: Nature. 2006 Nov 9

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• Lipopolysaccharide endotoxins.

  Bacterial lipopolysaccharides (LPS) typically consist of a hydrophobic domain known as lipid A (or endotoxin), a nonrepeating "core" oligosaccharide, …

  Authors: Christian R H Raetz, Chris Whitfield

  Source: Annual review of biochemistry. 2002

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• Periplasmic export machines for outer membrane assembly.

  The cell envelope of Gram-negative bacteria protects the organism from environmental stresses, components of the innate immune response, and the actio…

  Authors: Chris Whitfield, James H Naismith

  Source: Current opinion in structural biology. 2008 Aug

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• Crystal structures of Wzb of Escherichia coli and CpsB of Streptococcus pneumoniae, representatives of two families of tyrosine phosphatases that regulate capsule assembly.

  Many Gram-positive and Gram-negative bacteria utilize polysaccharide surface layers called capsules to evade the immune system; consequently, the synt…

  Authors: Gregor Hagelueken, Hexian Huang, Iain L Mainprize, Chris Whitfield, James H Naismith

  Source: Journal of molecular biology. 2009 Sep 25

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• Characterization of Gla(KP), a UDP-galacturonic acid C4-epimerase from Klebsiella pneumoniae with extended substrate specificity.

  In Escherichia coli and Salmonella enterica, the core oligosaccharide backbone of the lipopolysaccharide is modified by phosphoryl groups. The negativ…

  Authors: Emilisa Frirdich, Chris Whitfield

  Source: Journal of bacteriology. 2005 Jun

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• functional analysis of conserved gene products involved in assembly of Escherichia coli capsules and exopolysaccharides: evidence for molecular recognition between Wza and Wzc for colanic acid biosynthesis.

  Group 1 capsular polysaccharides (CPSs) of Escherichia coli and some loosely cell-associated exopolysaccharides (EPSs), such as colanic acid, are asse…

  Authors: Anne N Reid, Chris Whitfield

  Source: Journal of bacteriology. 2005 Aug

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• Structure-function relationships of the outer membrane translocon Wza investigated by cryo-electron microscopy and mutagenesis.

  The outer membrane protein Wza, from Escherichia coli K30, forms an octameric complex that is essential for capsular polysaccharide export. Homologs o…

  Authors: Robert C Ford, Anne L Brunkan-LaMontagne, Richard F Collins, Bradley R Clarke, Robert Harris, James H Naismith, Chris Whitfield

  Source: Journal of structural biology. 2009 May

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• Transcriptional organization and regulation of the Escherichia coli K30 group 1 capsule biosynthesis (cps) gene cluster.

  Escherichia coli group 1 capsules are important virulence determinants, yet little is known about the transcriptional organization or regulation of th…

  Authors: Andrea Rahn, Chris Whitfield

  Source: Molecular microbiology. 2003 Feb

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• Functional characterization of the initiation enzyme of S-layer glycoprotein glycan biosynthesis in Geobacillus stearothermophilus NRS 2004/3a.

  The glycan chain of the S-layer glycoprotein of Geobacillus stearothermophilus NRS 2004/3a is composed of repeating units [-->2)-alpha-l-Rhap-(1-->3)-…

  Authors: Kerstin Steiner, René Novotny, Kinnari Patel, Evgenij Vinogradov, Chris Whitfield, Miguel A Valvano, Paul Messner, Christina Schäffer

  Source: Journal of bacteriology. 2007 Apr

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