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Mutation of the gene PARK2, which encodes an E3 ubiquitin ligase, is the most common cause of early-onset Parkinson's disease. In a search for multisi…
Authors: Selvaraju Veeriah, Barry S Taylor, Shasha Meng, Fang Fang, Emrullah Yilmaz, Igor Vivanco, Manickam Janakiraman, Nikolaus Schultz, Aphrothiti J Hanrahan, William Pao,…
Source: Nature genetics. 2010 Jan
View Full TextTransfection of small RNAs (such as small interfering RNAs (siRNAs) and microRNAs (miRNAs)) into cells typically lowers expression of many genes. Unex…
Authors: Aly A Khan, Doron Betel, Martin L Miller, Chris Sander, Christina S Leslie, Debora S Marks
Source: Nature biotechnology. 2009 Jun
View Free Full TextThe TMPRSS2-ERG fusion, present in approximately 50% of prostate cancers, is less common in prostatic intraepithelial neoplasia (PIN), raising questio…
Authors: Jennifer C King, Jin Xu, John Wongvipat, Haley Hieronymus, Brett S Carver, David H Leung, Barry S Taylor, Chris Sander, Robert D Cardiff, Suzana S Couto,…
Source: Nature genetics. 2009 May
View Full TextThe miR-17 approximately 92 cluster is frequently amplified or overexpressed in human cancers and has emerged as the prototypical oncogenic polycistro…
Authors: Ping Mu, Yoon-Chi Han, Doron Betel, Evelyn Yao, Massimo Squatrito, Paul Ogrodowski, Elisa de Stanchina, Aleco D'Andrea, Chris Sander, Andrea Ventura
Source: Genes & development. 2009 Dec 15
View Full TextMemory storage and memory-related synaptic plasticity rely on precise spatiotemporal regulation of gene expression. To explore the role of small regul…
Authors: Priyamvada Rajasethupathy, Ferdinando Fiumara, Robert Sheridan, Doron Betel, Sathyanarayanan V Puthanveettil, James J Russo, Chris Sander, Thomas Tuschl, Eric Kandel
Source: Neuron. 2009 Sep 24
View Full TextSmall RNAs bound to Argonaute proteins recognize partially or fully complementary nucleic acid targets in diverse gene-silencing processes. A subgroup…
Authors: Alexei Aravin, Dimos Gaidatzis, Sébastien Pfeffer, Mariana Lagos-Quintana, Pablo Landgraf, Nicola Iovino, Patricia Morris, Michael J Brownstein, Satomi Kuramochi-Miyagawa, Toru Nakano,…
Source: Nature. 2006 Jul 13
View Full TextMicroRNAs are small noncoding RNAs that control gene function posttranscriptionally through mRNA degradation or translational inhibition. Much has bee…
Authors: Dan Leaman, Po Yu Chen, John Fak, Abdullah Yalcin, Michael Pearce, Ulrich Unnerstall, Debora S Marks, Chris Sander, Thomas Tuschl, Ulrike Gaul
Source: Cell. 2005 Jul 1
View Full TextMicroRNA.org (http://www.microrna.org) is a comprehensive resource of microRNA target predictions and expression profiles. Target predictions are base…
Authors: Doron Betel, Manda Wilson, Aaron Gabow, Debora S Marks, Chris Sander
Source: Nucleic acids research. 2008 Jan
View Full TextCircuit diagrams and Unified Modeling Language diagrams are just two examples of standard visual languages that help accelerate work by promoting regu…
Authors: Nicolas Le Novère, Michael Hucka, Huaiyu Mi, Stuart Moodie, Falk Schreiber, Anatoly Sorokin, Emek Demir, Katja Wegner, Mirit I Aladjem, Sarala M Wimalaratne,…
Source: Nature biotechnology. 2009 Aug
View Full TextMicroRNAs (miRNAs) are small noncoding regulatory RNAs that reduce stability and/or translation of fully or partially sequence-complementary target mR…
Authors: Pablo Landgraf, Mirabela Rusu, Robert Sheridan, Alain Sewer, Nicola Iovino, Alexei Aravin, Sébastien Pfeffer, Amanda Rice, Alice O Kamphorst, Markus Landthaler,…
Source: Cell. 2007 Jun 29
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