1 to 10 of 54 literature results

• Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies.

  Mutation of the gene PARK2, which encodes an E3 ubiquitin ligase, is the most common cause of early-onset Parkinson's disease. In a search for multisi…

  Authors: Selvaraju Veeriah, Barry S Taylor, Shasha Meng, Fang Fang, Emrullah Yilmaz, Igor Vivanco, Manickam Janakiraman, Nikolaus Schultz, Aphrothiti J Hanrahan, William Pao,…

  Source: Nature genetics. 2010 Jan

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• Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs.

  Transfection of small RNAs (such as small interfering RNAs (siRNAs) and microRNAs (miRNAs)) into cells typically lowers expression of many genes. Unex…

  Authors: Aly A Khan, Doron Betel, Martin L Miller, Chris Sander, Christina S Leslie, Debora S Marks

  Source: Nature biotechnology. 2009 Jun

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• Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis.

  The TMPRSS2-ERG fusion, present in approximately 50% of prostate cancers, is less common in prostatic intraepithelial neoplasia (PIN), raising questio…

  Authors: Jennifer C King, Jin Xu, John Wongvipat, Haley Hieronymus, Brett S Carver, David H Leung, Barry S Taylor, Chris Sander, Robert D Cardiff, Suzana S Couto,…

  Source: Nature genetics. 2009 May

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• Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomas.

  The miR-17 approximately 92 cluster is frequently amplified or overexpressed in human cancers and has emerged as the prototypical oncogenic polycistro…

  Authors: Ping Mu, Yoon-Chi Han, Doron Betel, Evelyn Yao, Massimo Squatrito, Paul Ogrodowski, Elisa de Stanchina, Aleco D'Andrea, Chris Sander, Andrea Ventura

  Source: Genes & development. 2009 Dec 15

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• Characterization of small RNAs in aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB.

  Memory storage and memory-related synaptic plasticity rely on precise spatiotemporal regulation of gene expression. To explore the role of small regul…

  Authors: Priyamvada Rajasethupathy, Ferdinando Fiumara, Robert Sheridan, Doron Betel, Sathyanarayanan V Puthanveettil, James J Russo, Chris Sander, Thomas Tuschl, Eric Kandel

  Source: Neuron. 2009 Sep 24

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• A novel class of small RNAs bind to MILI protein in mouse testes.

  Small RNAs bound to Argonaute proteins recognize partially or fully complementary nucleic acid targets in diverse gene-silencing processes. A subgroup…

  Authors: Alexei Aravin, Dimos Gaidatzis, Sébastien Pfeffer, Mariana Lagos-Quintana, Pablo Landgraf, Nicola Iovino, Patricia Morris, Michael J Brownstein, Satomi Kuramochi-Miyagawa, Toru Nakano,…

  Source: Nature. 2006 Jul 13

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• Antisense-mediated depletion reveals essential and specific functions of microRNAs in Drosophila development.

  MicroRNAs are small noncoding RNAs that control gene function posttranscriptionally through mRNA degradation or translational inhibition. Much has bee…

  Authors: Dan Leaman, Po Yu Chen, John Fak, Abdullah Yalcin, Michael Pearce, Ulrich Unnerstall, Debora S Marks, Chris Sander, Thomas Tuschl, Ulrike Gaul

  Source: Cell. 2005 Jul 1

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• The microRNA.org resource: targets and expression.

  MicroRNA.org (http://www.microrna.org) is a comprehensive resource of microRNA target predictions and expression profiles. Target predictions are base…

  Authors: Doron Betel, Manda Wilson, Aaron Gabow, Debora S Marks, Chris Sander

  Source: Nucleic acids research. 2008 Jan

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• The Systems Biology Graphical Notation.

  Circuit diagrams and Unified Modeling Language diagrams are just two examples of standard visual languages that help accelerate work by promoting regu…

  Authors: Nicolas Le Novère, Michael Hucka, Huaiyu Mi, Stuart Moodie, Falk Schreiber, Anatoly Sorokin, Emek Demir, Katja Wegner, Mirit I Aladjem, Sarala M Wimalaratne,…

  Source: Nature biotechnology. 2009 Aug

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• A mammalian microRNA expression atlas based on small RNA library sequencing.

  MicroRNAs (miRNAs) are small noncoding regulatory RNAs that reduce stability and/or translation of fully or partially sequence-complementary target mR…

  Authors: Pablo Landgraf, Mirabela Rusu, Robert Sheridan, Alain Sewer, Nicola Iovino, Alexei Aravin, Sébastien Pfeffer, Amanda Rice, Alice O Kamphorst, Markus Landthaler,…

  Source: Cell. 2007 Jun 29

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