10 literature results

• Lung cancer: intragenic ERBB2 kinase mutations in tumours.

  The protein-kinase family is the most frequently mutated gene family found in human cancer and faulty kinase enzymes are being investigated as promisi…

  Authors: Philip Stephens, Chris Hunter, Graham Bignell, Sarah Edkins, Helen Davies, Jon Teague, Claire Stevens, Sarah O'Meara, Raffaella Smith, Adrian Parker,…

  Source: Nature. 2004 Sep 30

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• A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer.

  We examined the coding sequence of 518 protein kinases, approximately 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no s…

  Authors: Philip Stephens, Sarah Edkins, Helen Davies, Chris Greenman, Charles Cox, Chris Hunter, Graham Bignell, Jon Teague, Raffaella Smith, Claire Stevens,…

  Source: Nature genetics. 2005 Jun

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• A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy.

  Malignant gliomas have a very poor prognosis. The current standard of care for these cancers consists of extended adjuvant treatment with the alkylati…

  Authors: Chris Hunter, Raffaella Smith, Daniel P Cahill, Philip Stephens, Claire Stevens, Jon Teague, Chris Greenman, Sarah Edkins, Graham Bignell, Helen Davies,…

  Source: Cancer research. 2006 Apr 15

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• Somatic mutations of the protein kinase gene family in human lung cancer.

  Protein kinases are frequently mutated in human cancer and inhibitors of mutant protein kinases have proven to be effective anticancer drugs. We scree…

  Authors: Helen Davies, Chris Hunter, Raffaella Smith, Philip Stephens, Chris Greenman, Graham Bignell, Jon Teague, Adam Butler, Sarah Edkins, Claire Stevens,…

  Source: Cancer research. 2005 Sep 1

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• Recurrent KRAS codon 146 mutations in human colorectal cancer.

  An activating point mutation in codon 12 of the HRAS gene was the first somatic point mutation identified in a human cancer and established the role o…

  Authors: Sarah Edkins, Sarah O'Meara, Adrian Parker, Claire Stevens, Marcelo Reis, Siân Jones, Chris Greenman, Helen Davies, Gillian Dalgliesh, Simon Forbes,…

  Source: Cancer biology & therapy. 2006 Aug

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• Subunit 3 of the COP9 signalosome is poised to facilitate communication between the extracellular matrix and the nucleus through the muscle-specific beta1D integrin.

  Yeast two-hybrid analysis (Fields and Song, 1989, Nature, 340:245-246) was used to screen a human heart library to isolate proteins interacting with t…

  Authors: Chris Hunter, Jennifer Evans, Maria L Valencik

  Source: Cell communication & adhesion. 2008 Sep

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• Generation of a conditional CREB Ser133Ala knockin mouse.

  Phosphorylation of Ser133 in the transcription factor CREB is an important mechanism for regulating its transcriptional activity, however recent work …

  Authors: Andrew D Wingate, Kirsty J Martin, Chris Hunter, Julia M Carr, Carol Clacher, J Simon C Arthur

  Source: Genesis (New York, N.Y. : 2000). 2009 Oct

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• Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.

  The panel of 60 human cancer cell lines (the NCI-60) assembled by the National Cancer Institute for anticancer drug discovery is a widely used resourc…

  Authors: Ogechi N Ikediobi, Helen Davies, Graham Bignell, Sarah Edkins, Claire Stevens, Sarah O'Meara, Thomas Santarius, Tim Avis, Syd Barthorpe, Lisa Brackenbury,…

  Source: Molecular cancer therapeutics. 2006 Nov

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• Opposing roles for RelB and Bcl-3 in regulation of T-box expressed in T cells, GATA-3, and Th effector differentiation.

  CD4+ T cells with a block in the NF-kappaB signaling pathway exhibit decreases in Th1 responses and diminished nuclear levels of multiple transactivat…

  Authors: Radiah A Corn, Chris Hunter, Hsiou-Chi Liou, Ulrich Siebenlist, Mark R Boothby

  Source: Journal of immunology (Baltimore, Md. : 1950). 2005 Aug 15

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• Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults.

  The protein kinase gene family is the most frequently mutated in human cancer. Previous work has documented activating mutations in the KIT receptor t…

  Authors: Graham Bignell, Raffaella Smith, Chris Hunter, Philip Stephens, Helen Davies, Chris Greenman, Jon Teague, Adam Butler, Sarah Edkins, Claire Stevens,…

  Source: Genes, chromosomes & cancer. 2006 Jan

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