10 literature results

• Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes.

  An appropriate beta cell mass is pivotal for the maintenance of glucose homeostasis. Both insulin and IGF-1 are important in regulation of beta cell g…

  Authors: Kohjiro Ueki, Terumasa Okada, Jiang Hu, Chong Wee Liew, Anke Assmann, Gabriella M Dahlgren, Jennifer L Peters, Jonathan G Shackman, Min Zhang, Isabella Artner,…

  Source: Nature genetics. 2006 May

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• Melanin concentrating hormone is a novel regulator of islet function and growth.

  Melanin concentrating hormone (MCH) is a hypothalamic neuropeptide known to play a critical role in energy balance. We have previously reported that o…

  Authors: Pavlos Pissios, Umut Ozcan, Efi Kokkotou, Terumasa Okada, Chong Wee Liew, Siming Liu, Jennifer N Peters, Gabriella Dahlgren, Jason Karamchandani, Yogish C Kudva,…

  Source: Diabetes. 2007 Feb

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• Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3.

  LKB1 is a tumor suppressor that may also be fundamental to cell metabolism, since LKB1 phosphorylates and activates the energy sensing enzyme AMPK. We…

  Authors: Ho-Jin Koh, David E Arnolds, Nobuharu Fujii, Thien T Tran, Marc J Rogers, Niels Jessen, Yangfeng Li, Chong Wee Liew, Richard C Ho, Michael F Hirshman,…

  Source: Molecular and cellular biology. 2006 Nov

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• Interaction of the human somatostatin receptor 3 with the multiple PDZ domain protein MUPP1 enables somatostatin to control permeability of epithelial tight junctions.

  The presence of heterotrimeric G-proteins at epithelial tight junctions suggests that these cellular junctions are regulated by so far unknown G-prote…

  Authors: Chong Wee Liew, Matthias Vockel, Günter Glassmeier, Johanna M Brandner, Gregorio J Fernandez-Ballester, Jürgen R Schwarz, Stefan Schulz, Friedrich Buck, Luis Serrano, Dietmar Richter,…

  Source: FEBS letters. 2009 Jan 5

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• High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and {beta}-cell apoptosis.

  Patients with type 2 diabetes lose beta cells, but the underlying mechanisms are incompletely understood. Glucose-6-phosphate dehydrogenase (G6PD) is …

  Authors: Zhaoyun Zhang, Chong Wee Liew, Diane E Handy, Yingyi Zhang, Jane A Leopold, Ji Hu, Lili Guo, Rohit N Kulkarni, Joseph Loscalzo, Robert C Stanton

  Source: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2009 Dec 23

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• Insulin signaling regulates mitochondrial function in pancreatic beta-cells.

  Insulin/IGF-I signaling regulates the metabolism of most mammalian tissues including pancreatic islets. To dissect the mechanisms linking insulin sign…

  Authors: Siming Liu, Terumasa Okada, Anke Assmann, Jamie Soto, Chong Wee Liew, Heiko Bugger, Orian S Shirihai, E Dale Abel, Rohit N Kulkarni

  Source: PloS one. 2009

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• Insulin signaling in alpha cells modulates glucagon secretion in vivo.

  Glucagon plays an important role in glucose homeostasis by regulating hepatic glucose output in both normo- and hypoglycemic conditions. In this study…

  Authors: Dan Kawamori, Amarnath J Kurpad, Jiang Hu, Chong Wee Liew, Judy L Shih, Eric L Ford, Pedro L Herrera, Kenneth S Polonsky, Owen P McGuinness, Rohit N Kulkarni

  Source: Cell metabolism. 2009 Apr

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• Postsynaptic shank antagonizes dendrite branching induced by the leucine-rich repeat protein Densin-180.

  Leucine-rich repeat and PDZ [postsynaptic density-95 (PSD-95)/Discs large/zona occludens-1] domain proteins such as scribble and Densin-180 have been …

  Authors: Arne Quitsch, Kerstin Berhörster, Chong Wee Liew, Dietmar Richter, Hans-Jürgen Kreienkamp

  Source: The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005 Jan 12

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• Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance.

  Insulin and insulin-like growth factor 1 (IGF1) are ubiquitous growth factors that regulate proliferation in most mammalian tissues including pancreat…

  Authors: Terumasa Okada, Chong Wee Liew, Jiang Hu, Charlotte Hinault, M Dodson Michael, Jan Krtzfeldt, Catherine Yin, Martin Holzenberger, Markus Stoffel, Rohit N Kulkarni

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2007 May 22

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• TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism.

  During fasting, increased concentrations of circulating catecholamines promote the mobilization of lipid stores from adipose tissue in part by phospho…

  Authors: Ling Qi, Jose E Heredia, Judith Y Altarejos, Robert Screaton, Naomi Goebel, Sherry Niessen, Ian X Macleod, Chong Wee Liew, Rohit N Kulkarni, James Bain,…

  Source: Science (New York, N.Y.). 2006 Jun 23

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