1 to 10 of 58 literature results

• A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKgamma to dampen the host NF-kappaB-mediated inflammatory response.

  NF-kappaB (nuclear factor kappaB) has a pivotal role in many cellular processes, including the inflammatory and immune responses and, therefore, its a…

  Authors: Hiroshi Ashida, Minsoo Kim, Marc Schmidt-Supprian, Averil Ma, Michinaga Ogawa, Chihiro Sasakawa

  Source: Nature cell biology. 2010 Jan

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• Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment.

  The rapid turnover and exfoliation of mucosal epithelial cells provides an innate defence system against bacterial infection. Nevertheless, many patho…

  Authors: Minsoo Kim, Michinaga Ogawa, Yukihiro Fujita, Yuko Yoshikawa, Takeshi Nagai, Tomohiro Koyama, Shinya Nagai, Anika Lange, Reinhard Fässler, Chihiro Sasakawa

  Source: Nature. 2009 May 28

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• A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling.

  The gut epithelium self-renews every several days, providing an important innate defense system that limits bacterial colonization. Nevertheless, many…

  Authors: Hiroki Iwai, Minsoo Kim, Yuko Yoshikawa, Hiroshi Ashida, Michinaga Ogawa, Yukihiro Fujita, Daniel Muller, Teruo Kirikae, Peter K Jackson, Shuji Kotani,…

  Source: Cell. 2007 Aug 24

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• Listeria monocytogenes ActA-mediated escape from autophagic recognition.

  Autophagy degrades unnecessary organelles and misfolded protein aggregates, as well as cytoplasm-invading bacteria. Nevertheless, the bacteria Listeri…

  Authors: Yuko Yoshikawa, Michinaga Ogawa, Torsten Hain, Mitsutaka Yoshida, Makoto Fukumatsu, Minsoo Kim, Hitomi Mimuro, Ichiro Nakagawa, Toru Yanagawa, Tetsuro Ishii,…

  Source: Nature cell biology. 2009 Oct

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• Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses.

  Interleukin-17A (IL-17A) is a cytokine produced by T helper 17 (Th17) cells and plays important roles in the development of inflammatory diseases. Alt…

  Authors: Harumichi Ishigame, Shigeru Kakuta, Takeshi Nagai, Motohiko Kadoki, Aya Nambu, Yutaka Komiyama, Noriyuki Fujikado, Yuko Tanahashi, Aoi Akitsu, Hayato Kotaki,…

  Source: Immunity. 2009 Jan 16

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• Shigella IpgB1 promotes bacterial entry through the ELMO-Dock180 machinery.

  Shigella use a special mechanism to invade epithelial cells called 'the trigger mechanism of entry', which allows epithelial cells to trap several bac…

  Authors: Yutaka Handa, Masato Suzuki, Kenji Ohya, Hiroki Iwai, Nozomi Ishijima, Anthony J Koleske, Yoshinori Fukui, Chihiro Sasakawa

  Source: Nature cell biology. 2007 Jan

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• Bacterial evasion of the autophagic defense system.

  Autophagy is a conserved membrane-traffic pathway in eukaryotic cells that sequesters cytoplasmic components and delivers them to lysosomes. Recent re…

  Authors: Michinaga Ogawa, Chihiro Sasakawa

  Source: Current opinion in microbiology. 2006 Feb

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• Helicobacter pylori cytotoxin-associated gene A activates the signal transducer and activator of transcription 3 pathway in vitro and in vivo.

  Persistent infection with Helicobacter pylori confers an increased risk for the development of gastric cancer. However, the exact mechanisms whereby t…

  Authors: Dana M Bronte-Tinkew, Mauricio Terebiznik, Aime Franco, Michelle Ang, Diane Ahn, Hitomi Mimuro, Chihiro Sasakawa, Mark J Ropeleski, Richard M Peek, Nicola L Jones

  Source: Cancer research. 2009 Jan 15

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• Intracellular survival of Shigella.

  Bacterial invasion of eukaryotic cells and host recognition and killing of the invading bacteria are a key issue in determining the fate of bacterial …

  Authors: Michinaga Ogawa, Chihiro Sasakawa

  Source: Cellular microbiology. 2006 Feb

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• Shigella chromosomal IpaH proteins are secreted via the type III secretion system and act as effectors.

  Shigella possess 220 kb plasmid, and the major virulence determinants, called effectors, and the type III secretion system (TTSS) are exclusively enco…

  Authors: Hiroshi Ashida, Takahito Toyotome, Takeshi Nagai, Chihiro Sasakawa

  Source: Molecular microbiology. 2007 Feb

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