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NF-kappaB (nuclear factor kappaB) has a pivotal role in many cellular processes, including the inflammatory and immune responses and, therefore, its a…
Authors: Hiroshi Ashida, Minsoo Kim, Marc Schmidt-Supprian, Averil Ma, Michinaga Ogawa, Chihiro Sasakawa
Source: Nature cell biology. 2010 Jan
View Full TextThe rapid turnover and exfoliation of mucosal epithelial cells provides an innate defence system against bacterial infection. Nevertheless, many patho…
Authors: Minsoo Kim, Michinaga Ogawa, Yukihiro Fujita, Yuko Yoshikawa, Takeshi Nagai, Tomohiro Koyama, Shinya Nagai, Anika Lange, Reinhard Fässler, Chihiro Sasakawa
Source: Nature. 2009 May 28
View Full TextThe gut epithelium self-renews every several days, providing an important innate defense system that limits bacterial colonization. Nevertheless, many…
Authors: Hiroki Iwai, Minsoo Kim, Yuko Yoshikawa, Hiroshi Ashida, Michinaga Ogawa, Yukihiro Fujita, Daniel Muller, Teruo Kirikae, Peter K Jackson, Shuji Kotani,…
Source: Cell. 2007 Aug 24
View Full TextAutophagy degrades unnecessary organelles and misfolded protein aggregates, as well as cytoplasm-invading bacteria. Nevertheless, the bacteria Listeri…
Authors: Yuko Yoshikawa, Michinaga Ogawa, Torsten Hain, Mitsutaka Yoshida, Makoto Fukumatsu, Minsoo Kim, Hitomi Mimuro, Ichiro Nakagawa, Toru Yanagawa, Tetsuro Ishii,…
Source: Nature cell biology. 2009 Oct
View Full TextInterleukin-17A (IL-17A) is a cytokine produced by T helper 17 (Th17) cells and plays important roles in the development of inflammatory diseases. Alt…
Authors: Harumichi Ishigame, Shigeru Kakuta, Takeshi Nagai, Motohiko Kadoki, Aya Nambu, Yutaka Komiyama, Noriyuki Fujikado, Yuko Tanahashi, Aoi Akitsu, Hayato Kotaki,…
Source: Immunity. 2009 Jan 16
View Full TextShigella use a special mechanism to invade epithelial cells called 'the trigger mechanism of entry', which allows epithelial cells to trap several bac…
Authors: Yutaka Handa, Masato Suzuki, Kenji Ohya, Hiroki Iwai, Nozomi Ishijima, Anthony J Koleske, Yoshinori Fukui, Chihiro Sasakawa
Source: Nature cell biology. 2007 Jan
View Full TextAutophagy is a conserved membrane-traffic pathway in eukaryotic cells that sequesters cytoplasmic components and delivers them to lysosomes. Recent re…
Authors: Michinaga Ogawa, Chihiro Sasakawa
Source: Current opinion in microbiology. 2006 Feb
View Full TextPersistent infection with Helicobacter pylori confers an increased risk for the development of gastric cancer. However, the exact mechanisms whereby t…
Authors: Dana M Bronte-Tinkew, Mauricio Terebiznik, Aime Franco, Michelle Ang, Diane Ahn, Hitomi Mimuro, Chihiro Sasakawa, Mark J Ropeleski, Richard M Peek, Nicola L Jones
Source: Cancer research. 2009 Jan 15
View Full TextBacterial invasion of eukaryotic cells and host recognition and killing of the invading bacteria are a key issue in determining the fate of bacterial …
Authors: Michinaga Ogawa, Chihiro Sasakawa
Source: Cellular microbiology. 2006 Feb
View Full TextShigella possess 220 kb plasmid, and the major virulence determinants, called effectors, and the type III secretion system (TTSS) are exclusively enco…
Authors: Hiroshi Ashida, Takahito Toyotome, Takeshi Nagai, Chihiro Sasakawa
Source: Molecular microbiology. 2007 Feb
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