1 to 10 of 27 literature results

• Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells.

  The continuous renewal of human epidermis is sustained by stem cells contained in the epidermal basal layer and in hair follicles. Cultured keratinocy…

  Authors: Fulvio Mavilio, Graziella Pellegrini, Stefano Ferrari, Francesca Di Nunzio, Enzo Di Iorio, Alessandra Recchia, Giulietta Maruggi, Giuliana Ferrari, Elena Provasi, Chiara Bonini,…

  Source: Nature medicine. 2006 Dec

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• Clinical impact of suicide gene therapy in allogeneic hematopoietic stem cell transplantation.

  Abstract Allogeneic hematopoietic stem cell transplantation (allo-SCT) from an HLA-matched related or unrelated donor is a curative option for patient…

  Authors: Maria Teresa Lupo-Stanghellini, Elena Provasi, Attilio Bondanza, Fabio Ciceri, Claudio Bordignon, Chiara Bonini

  Source: Human gene therapy. 2010 Mar

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• The potential immunogenicity of the TK suicide gene does not prevent full clinical benefit associated with the use of TK-transduced donor lymphocytes in HSCT for hematologic malignancies.

  Gene therapy is a promising therapeutic strategy for genetic and acquired hematologic diseases. With the improvements in gene transfer and expression,…

  Authors: Catia Traversari, Sarah Marktel, Zulma Magnani, Patrizia Mangia, Vincenzo Russo, Fabio Ciceri, Chiara Bonini, Claudio Bordignon

  Source: Blood. 2007 Jun 1

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• The hidden (and lazy) TCR.

  Authors: Chiara Bonini, Vincenzo Russo

  Source: Blood. 2009 Oct 1

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• Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells.

  Dendritic cells (DCs) are specialized antigen-presenting cells that monitor the antigenic environment and activate naive T cells. The role of DCs is n…

  Authors: Megan K Levings, Silvia Gregori, Eleonora Tresoldi, Sabrina Cazzaniga, Chiara Bonini, Maria Grazia Roncarolo

  Source: Blood. 2005 Feb 1

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• IL-7 and IL-15 allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes.

  Long-term clinical remissions of leukemia, after allogeneic hematopoietic stem cell transplantation, depend on alloreactive memory T cells able to sel…

  Authors: Shin Kaneko, Sara Mastaglio, Attilio Bondanza, Maurilio Ponzoni, Francesca Sanvito, Luca Aldrighetti, Marina Radrizzani, Simona La Seta-Catamancio, Elena Provasi, Anna Mondino,…

  Source: Blood. 2009 Jan 29

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• Molecular modification of idiotypes from B-cell lymphomas for expression in mature dendritic cells as a strategy to induce tumor-reactive CD4+ and CD8+ T-cell responses.

  Most non-Hodgkin B-cell lymphomas (NHLs) are characterized by the clonal expansion of a single cell expressing a unique rearranged immunoglobulin gene…

  Authors: Sara Muraro, Attilio Bondanza, Matteo Bellone, Philip D Greenberg, Chiara Bonini

  Source: Blood. 2005 May 1

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• Temporal, quantitative, and functional characteristics of single-KIR-positive alloreactive natural killer cell recovery account for impaired graft-versus-leukemia activity after haploidentical hematopoietic stem cell transplantation.

  In this study, we have characterized reconstitution of the natural killer (NK) cell repertoire after haploidentical CD34(+) selected hematopoietic ste…

  Authors: Luca Vago, Barbara Forno, Maria Pia Sormani, Roberto Crocchiolo, Elisabetta Zino, Simona Di Terlizzi, Maria Teresa Lupo Stanghellini, Benedetta Mazzi, Serena K Perna, Attilio Bondanza,…

  Source: Blood. 2008 Oct 15

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• Suicide gene therapy of graft-versus-host disease induced by central memory human T lymphocytes.

  In allogeneic hematopoietic cell transplantation (allo-HCT), the immune recognition of host antigens by donor T lymphocytes leads to a beneficial graf…

  Authors: Attilio Bondanza, Veronica Valtolina, Zulma Magnani, Maurilio Ponzoni, Katharina Fleischhauer, Mark Bonyhadi, Catia Traversari, Francesca Sanvito, Salvatore Toma, Marina Radrizzani,…

  Source: Blood. 2006 Mar 1

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• Antitumor effects of HSV-TK-engineered donor lymphocytes after allogeneic stem-cell transplantation.

  The extensive exploitation of the antitumor effect of donor lymphocytes infused after allogeneic hematopoietic stem-cell transplantation (allo-HSCT) i…

  Authors: Fabio Ciceri, Chiara Bonini, Sarah Marktel, Elisabetta Zappone, Paolo Servida, Massimo Bernardi, Alessandra Pescarollo, Attilio Bondanza, Jacopo Peccatori, Silvano Rossini,…

  Source: Blood. 2007 Jun 1

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