1 to 10 of 16 literature results

• Wza the translocon for E. coli capsular polysaccharides defines a new class of membrane protein.

  Many types of bacteria produce extracellular polysaccharides (EPSs). Some are secreted polymers and show only limited association with the cell surfac…

  Authors: Changjiang Dong, Konstantinos Beis, Jutta Nesper, Anne L Brunkan-Lamontagne, Bradley R Clarke, Chris Whitfield, James H Naismith

  Source: Nature. 2006 Nov 9

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• Crystal structure and mechanism of a bacterial fluorinating enzyme.

  Fluorine is the thirteenth most abundant element in the earth's crust, but fluoride concentrations in surface water are low and fluorinated metabolite…

  Authors: Changjiang Dong, Fanglu Huang, Hai Deng, Christoph Schaffrath, Jonathan B Spencer, David O'Hagan, James H Naismith

  Source: Nature. 2004 Feb 5

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• The structural basis of chain length control in Rv1086.

  In Mycobacterium tuberculosis, two related Z-prenyl diphosphate synthases, E,Z-farnesyl diphosphate synthase (Rv1086) and decaprenyl diphosphate synth…

  Authors: Wenjian Wang, Changjiang Dong, Michael McNeil, Devinder Kaur, Sebabrata Mahapatra, Dean C Crick, James H Naismith

  Source: Journal of molecular biology. 2008 Aug 1

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• RmlC, a C3' and C5' carbohydrate epimerase, appears to operate via an intermediate with an unusual twist boat conformation.

  The striking feature of carbohydrates is their constitutional, conformational and configurational diversity. Biology has harnessed this diversity and …

  Authors: Changjiang Dong, Louise L Major, Velupillai Srikannathasan, James C Errey, Marie-France Giraud, Joseph S Lam, Michael Graninger, Paul Messner, Michael R McNeil, Robert A Field,…

  Source: Journal of molecular biology. 2007 Jan 5

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• Novel inhibitors of an emerging target in Mycobacterium tuberculosis; substituted thiazolidinones as inhibitors of dTDP-rhamnose synthesis.

  The emergence of multi-drug resistant tuberculosis, coupled with the increasing overlap of the AIDS and tuberculosis pandemics has brought tuberculosi…

  Authors: Kerim Babaoglu, Mark A Page, Victoria C Jones, Michael R McNeil, Changjiang Dong, James H Naismith, Richard E Lee

  Source: Bioorganic & medicinal chemistry letters. 2003 Oct 6

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• The structure of an open form of an E. coli mechanosensitive channel at 3.45 A resolution.

  How ion channels are gated to regulate ion flux in and out of cells is the subject of intense interest. The Escherichia coli mechanosensitive channel,…

  Authors: Wenjian Wang, Susan S Black, Michelle D Edwards, Samantha Miller, Emma L Morrison, Wendy Bartlett, Changjiang Dong, James H Naismith, Ian R Booth

  Source: Science (New York, N.Y.). 2008 Aug 29

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• The structure of SENP1-SUMO-2 complex suggests a structural basis for discrimination between SUMO paralogues during processing.

  The SUMO (small ubiquitin-like modifier)-specific protease SENP1 (sentrin-specific protease 1) can process the three forms of SUMO to their mature for…

  Authors: Lin Nan Shen, Changjiang Dong, Huanting Liu, James H Naismith, Ronald T Hay

  Source: The Biochemical journal. 2006 Jul 15

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• Biological halogenation has moved far beyond haloperoxidases.

  Authors: Karl-Heinz van Pée, Changjiang Dong, Silvana Flecks, Jim Naismith, Eugenio P Patallo, Tobias Wage

  Source: Advances in applied microbiology. 2006

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• The 3D structure of a periplasm-spanning platform required for assembly of group 1 capsular polysaccharides in Escherichia coli.

  Capsular polysaccharides (CPSs) are essential virulence determinants of many pathogenic bacteria. Escherichia coli group 1 CPSs provide paradigms for …

  Authors: Richard F Collins, Konstantinos Beis, Changjiang Dong, Catherine H Botting, Catherine McDonnell, Robert C Ford, Bradley R Clarke, Chris Whitfield, James H Naismith

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2007 Feb 13

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• SUMO protease SENP1 induces isomerization of the scissile peptide bond.

  Small ubiquitin-like modifier (SUMO)-specific protease SENP1 processes SUMO-1, SUMO-2 and SUMO-3 to mature forms and deconjugates them from modified p…

  Authors: Linnan Shen, Michael H Tatham, Changjiang Dong, Anna Zagórska, James H Naismith, Ronald T Hay

  Source: Nature structural & molecular biology. 2006 Dec

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