1 to 8 of 8 literature results

• Proteasome inhibitor PS-341, a potential therapeutic agent for adult T-cell leukemia.

  Nuclear factor kappaB (NF-kappaB) plays a major role in the pathogenesis of human T-cell lymphotrophic virus I-associated malignancy. Proteasome inhib…

  Authors: Chalet Tan, Thomas A Waldmann

  Source: Cancer research. 2002 Feb 15

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• Combination of rapamycin and 17-allylamino-17-demethoxygeldanamycin abrogates Akt activation and potentiates mTOR blockade in breast cancer cells.

  Increased Akt phosphorylation was reported in cancer cell lines and tumor tissues of patients exposed to rapamycin, a response likely contributing to …

  Authors: Matthew M Roforth, Chalet Tan

  Source: Anti-cancer drugs. 2008 Aug

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• Synthesis of functionalized carboranes as potential anticancer and BNCT agents.

  Carboranyl aldehydes react with alpha,beta-unsaturated esters, ketones, and nitriles in the presence of DABCO to provide functionalized carboranyl alc…

  Authors: Venkata Jaganmohan Reddy, Matthew M Roforth, Chalet Tan, M Venkat Ram Reddy

  Source: Inorganic chemistry. 2007 Jan 22

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• Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway.

  Hypoxia-inducible factor 1 (HIF-1) is the central mediator of cellular responses to low oxygen and has recently become an important therapeutic target…

  Authors: Chalet Tan, Rita G de Noronha, Anthony J Roecker, Beata Pyrzynska, Fatima Khwaja, Zhaobin Zhang, Huanchun Zhang, Quincy Teng, Ainsley C Nicholson, Paraskevi Giannakakou,…

  Source: Cancer research. 2005 Jan 15

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• Efavirenz therapy in rhesus macaques infected with a chimera of simian immunodeficiency virus containing reverse transcriptase from human immunodeficiency virus type 1.

  The specificity of nonnucleoside reverse transcriptase (RT) inhibitors (NNRTIs) for the RT of human immunodeficiency virus type 1 (HIV-1) has prevente…

  Authors: Michael J Hofman, Joanne Higgins, Timothy B Matthews, Niels C Pedersen, Chalet Tan, Raymond F Schinazi, Thomas W North

  Source: Antimicrobial agents and chemotherapy. 2004 Sep

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• The boron-neutron capture agent beta-D-5-o-carboranyl-2'-deoxyuridine accumulates preferentially in dividing brain tumor cells.

  Boron-neutron capture therapy (BNCT) is based on the preferential targeting of tumor cells with (10)B and subsequent irradiation with epithermal neutr…

  Authors: Casey Moore, Brenda I Hernández-Santiago, Selwyn J Hurwitz, Chalet Tan, Chris Wang, Raymond F Schinazi

  Source: Journal of neuro-oncology. 2005 Sep

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• Genetic and hypoxic regulation of angiogenesis in gliomas.

  Infiltrative astrocytic neoplasms are by far the most common malignant brain tumors in adults. Clinically, they are highly problematic due to their wi…

  Authors: Balveen Kaur, Chalet Tan, Daniel J Brat, Dawn E Post, Erwin G Van Meir

  Source: Journal of neuro-oncology. 2004 Nov

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• Microregional extracellular matrix heterogeneity in brain modulates glioma cell invasion.

  The invasion of neoplastic cells into healthy brain tissue is a pathologic hallmark of gliomas and contributes to the failure of current therapeutic m…

  Authors: Anita C Bellail, Stephen B Hunter, Daniel J Brat, Chalet Tan, Erwin G Van Meir

  Source: The international journal of biochemistry & cell biology. 2004 Jun

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