1 to 7 of 7 literature results

• Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.

  Adipocyte fatty-acid-binding protein, aP2 (FABP4) is expressed in adipocytes and macrophages, and integrates inflammatory and metabolic responses. Stu…

  Authors: Masato Furuhashi, Gürol Tuncman, Cem Z Görgün, Liza Makowski, Genichi Atsumi, Eric Vaillancourt, Keita Kono, Vladimir R Babaev, Sergio Fazio, MacRae F Linton,…

  Source: Nature. 2007 Jun 21

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• A central role for JNK in obesity and insulin resistance.

  Obesity is closely associated with insulin resistance and establishes the leading risk factor for type 2 diabetes mellitus, yet the molecular mechanis…

  Authors: Jiro Hirosumi, Gürol Tuncman, Lufen Chang, Cem Z Görgün, K Teoman Uysal, Kazuhisa Maeda, Michael Karin, Gökhan S Hotamisligil

  Source: Nature. 2002 Nov 21

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• Role of the fatty acid binding protein mal1 in obesity and insulin resistance.

  The metabolic syndrome is a cluster of metabolic and inflammatory abnormalities including obesity, insulin resistance, type 2 diabetes, hypertension, …

  Authors: Kazuhisa Maeda, K Teoman Uysal, Liza Makowski, Cem Z Görgün, Genichi Atsumi, Rex A Parker, Jens Brüning, Ann Vogel Hertzel, David A Bernlohr, Gökhan S Hotamisligil

  Source: Diabetes. 2003 Feb

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• Obesity modulates the expression of haptoglobin in the white adipose tissue via TNFalpha.

  Increase in adipose mass results in obesity and modulation of several factors in white adipose tissue (WAT). Two important examples are tumor necrosis…

  Authors: Chiara Chiellini, Anna Bertacca, Silvia E Novelli, Cem Z Görgün, Annamaria Ciccarone, Antonio Giordano, Haiyan Xu, Alexander Soukas, Mario Costa, Daniele Gandini,…

  Source: Journal of cellular physiology. 2002 Feb

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• Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice.

  Adipose tissue inflammation is a characteristic of obesity. However, the mechanisms that regulate this inflammatory response and link adipose inflamma…

  Authors: Masato Furuhashi, Raquel Fucho, Cem Z Görgün, Gürol Tuncman, Haiming Cao, Gökhan S Hotamisligil

  Source: The Journal of clinical investigation. 2008 Jul

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• Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes.

  Endoplasmic reticulum (ER) stress is a key link between obesity, insulin resistance, and type 2 diabetes. Here, we provide evidence that this mechanis…

  Authors: Umut Ozcan, Erkan Yilmaz, Lale Ozcan, Masato Furuhashi, Eric Vaillancourt, Ross O Smith, Cem Z Görgün, Gökhan S Hotamisligil

  Source: Science (New York, N.Y.). 2006 Aug 25

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• Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling.

  Elevated levels of tumor necrosis factor (TNFalpha) are implicated in the development of insulin resistance, but the mechanisms mediating these chroni…

  Authors: Gregory R Steinberg, Belinda J Michell, Bryce J W van Denderen, Matthew J Watt, Andrew L Carey, Barbara C Fam, Sofianos Andrikopoulos, Joseph Proietto, Cem Z Görgün, David Carling,…

  Source: Cell metabolism. 2006 Dec

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