1 to 6 of 6 literature results

• CD98hc facilitates B cell proliferation and adaptive humoral immunity.

  The proliferation of antigen-specific lymphocytes and resulting clonal expansion are essential for adaptive immunity. We report here that B cell-speci…

  Authors: Joseph Cantor, Cecille D Browne, Raphael Ruppert, Chloé C Féral, Reinhard Fässler, Robert C Rickert, Mark H Ginsberg

  Source: Nature immunology. 2009 Apr

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• Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy.

  Anergy is a critical physiologic mechanism to sensor self-reactive B cells. However, a biochemical understanding of how anergy is achieved and maintai…

  Authors: Cecille D Browne, Christopher J Del Nagro, Matthew H Cato, Hart S Dengler, Robert C Rickert

  Source: Immunity. 2009 Nov 20

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• Inhibition of endothelial cell proliferation and angiogenesis by orlistat, a fatty acid synthase inhibitor.

  Orlistat, an antiobesity drug, is cytostatic and cytotoxic to tumor cells. The antitumor activity of orlistat can be attributed to its ability to inhi…

  Authors: Cecille D Browne, Elizabeth J Hindmarsh, Jeffrey W Smith

  Source: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2006 Oct

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• A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2.

  In eukaryotes, fatty acid synthase (FAS) is the enzyme responsible for synthesis of palmitate, the precursor of long-chain nonessential fatty acids. F…

  Authors: Lynn M Knowles, Fumiko Axelrod, Cecille D Browne, Jeffrey W Smith

  Source: The Journal of biological chemistry. 2004 Jul 16

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• Inducible T cell tyrosine kinase regulates actin-dependent cytoskeletal events induced by the T cell antigen receptor.

  The tec family kinase, inducible T cell tyrosine kinase (Itk), is critical for both development and activation of T lymphocytes. We have found that It…

  Authors: Juris A Grasis, Cecille D Browne, Constantine D Tsoukas

  Source: Journal of immunology (Baltimore, Md. : 1950). 2003 Apr 15

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• Inducible T cell tyrosine kinase (ITK): structural requirements and actin polymerization.

  Authors: Constantine D Tsoukas, Juris A Grasis, Cecille D Browne, Keith A Ching

  Source: Advances in experimental medicine and biology. 2006

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