1 to 7 of 7 literature results

• ETS rearrangements and prostate cancer initiation.

  The first recurrent translocation event in prostate cancer has been recently described; it results in the translocation of an ETS (E26 transformation …

  Authors: Brett S Carver, Jennifer Tran, Zhenbang Chen, Arkaitz Carracedo-Perez, Andrea Alimonti, Caterina Nardella, Anuradha Gopalan, Peter T Scardino, Carlos Cordon-Cardo, William Gerald,…

  Source: Nature. 2009 Feb 12

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• Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate.

  Chromosomal translocations involving the ERG locus are frequent events in human prostate cancer pathogenesis; however, the biological role of aberrant…

  Authors: Brett S Carver, Jennifer Tran, Anuradha Gopalan, Zhenbang Chen, Safa Shaikh, Arkaitz Carracedo, Andrea Alimonti, Caterina Nardella, Shohreh Varmeh, Peter T Scardino,…

  Source: Nature genetics. 2009 May

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• Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events.

  The mammalian target of rapamycin (mTOR) represents a critical signaling crossroad where pathways commonly disrupted in cancer converge. We report her…

  Authors: Caterina Nardella, Zhenbang Chen, Leonardo Salmena, Arkaitz Carracedo, Andrea Alimonti, Ainara Egia, Brett Carver, William Gerald, Carlos Cordon-Cardo, Pier Paolo Pandolfi

  Source: Genes & development. 2008 Aug 15

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• Radiolabeled heparan sulfate immobilized on microplate as substrate for the detection of heparanase activity.

  We developed a quantitative assay to monitor the enzymatic activity of heparanase, a protein responsible for the degradation of heparan sulfate (HS) p…

  Authors: Caterina Nardella, Christian Steinkühler

  Source: Analytical biochemistry. 2004 Sep 15

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• Mechanism of activation of human heparanase investigated by protein engineering.

  The aim of this study was to investigate the mechanism of activation of human heparanase, a key player in heparan sulfate degradation, thought to be i…

  Authors: Caterina Nardella, Armin Lahm, Michele Pallaoro, Mirko Brunetti, Alessandro Vannini, Christian Steinkühler

  Source: Biochemistry. 2004 Feb 24

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• Differential requirement of mTOR in postmitotic tissues and tumorigenesis.

  The mammalian target of rapamycin (mTOR) is a crucial effector in a complex signaling network commonly disrupted in cancer. mTOR exerts its multiple f…

  Authors: Caterina Nardella, Arkaitz Carracedo, Andrea Alimonti, Robin M Hobbs, John G Clohessy, Zhenbang Chen, Ainara Egia, Alessandro Fornari, Michelangelo Fiorentino, Massimo Loda,…

  Source: Science signaling. 2009

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• Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer.

  Numerous studies have established a causal link between aberrant mammalian target of rapamycin (mTOR) activation and tumorigenesis, indicating that mT…

  Authors: Arkaitz Carracedo, Li Ma, Julie Teruya-Feldstein, Federico Rojo, Leonardo Salmena, Andrea Alimonti, Ainara Egia, Atsuo T Sasaki, George Thomas, Sara C Kozma,…

  Source: The Journal of clinical investigation. 2008 Sep

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