1 to 4 of 4 literature results

• Early drug safety evaluation: biomarkers, signatures, and fingerprints.

  When target organ toxicity arises in animal models during routine drug safety evaluation, it raises several key questions: Is this target organ toxici…

  Authors: Ruth Roberts, Kelvin Cain, Beth Coyle, Caroline Freathy, Jean-Francois Leonard, Jean-Charles Gautier

  Source: Drug metabolism reviews. 2003 Nov

  View Full Text

• Design and synthesis of new templates derived from pyrrolopyrimidine as selective multidrug-resistance-associated protein inhibitors in multidrug resistance.

  In our continued effort to identify selective MRP1 modulators, we have developed two novel templates, 3 and 4, through rational drug design by identif…

  Authors: Shouming Wang, Nan Chi Wan, John Harrison, Warren Miller, Irina Chuckowree, Sukhjit Sohal, Timothy C Hancox, Stewart Baker, Adrian Folkes, Francis Wilson,…

  Source: Journal of medicinal chemistry. 2004 Mar 11

  View Full Text

• Regulation of apoptosis by peroxisome proliferators.

  Peroxisome proliferators (PPs) constitute a large and chemically diverse family of non-genotoxic rodent hepatocarcinogens that activate the PP-activat…

  Authors: Ruth A Roberts, Cecile Michel, Beth Coyle, Caroline Freathy, Kelvin Cain, Eric Boitier

  Source: Toxicology letters. 2004 Apr 1

  View Full Text

• Characterization of the transforming growth factor-beta 1-induced apoptotic transcriptome in FaO hepatoma cells.

  We have previously shown that transforming growth factor-beta(1) (TGF-beta(1))-induced apoptosis in FaO hepatoma cells is mediated by cytochrome c rel…

  Authors: Beth Coyle, Caroline Freathy, Timothy W Gant, Ruth A Roberts, Kelvin Cain

  Source: The Journal of biological chemistry. 2003 Feb 21

  View Full Text