1 to 10 of 26 literature results

• Scattering orthogonalization of near-infrared spectra for analysis of pharmaceutical tablets.

  The paper explores scattering orthogonalization as a preprocessing technique to reduce physical interference and maintain chemical information in near…

  Authors: Zhenqi Shi, Carl A Anderson

  Source: Analytical chemistry. 2009 Feb 15

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• Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.

  Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combine…

  Authors: Jeffrey C Barrett, Sarah Hansoul, Dan L Nicolae, Judy H Cho, Richard H Duerr, John D Rioux, Steven R Brant, Mark S Silverberg, Kent D Taylor, M Michael Barmada,…

  Source: Nature genetics. 2008 Aug

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• Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.

  We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that…

  Authors: Sheila A Fisher, Mark Tremelling, Carl A Anderson, Rhian Gwilliam, Suzannah Bumpstead, Natalie J Prescott, Elaine R Nimmo, Dunecan Massey, Carlo Berzuini, Christopher Johnson,…

  Source: Nature genetics. 2008 Jun

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• Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.

  A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four n…

  Authors: Miles Parkes, Jeffrey C Barrett, Natalie J Prescott, Mark Tremelling, Carl A Anderson, Sheila A Fisher, Roland G Roberts, Elaine R Nimmo, Fraser R Cummings, Dianne Soars,…

  Source: Nature genetics. 2007 Jul

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• Evaluating the effects of imputation on the power, coverage, and cost efficiency of genome-wide SNP platforms.

  Genotype imputation is potentially a zero-cost method for bridging gaps in coverage and power between genotyping platforms. Here, we quantify these ga…

  Authors: Carl A Anderson, Fredrik H Pettersson, Jeffrey C Barrett, Joanna J Zhuang, Jiannis Ragoussis, Lon R Cardon, Andrew P Morris

  Source: American journal of human genetics. 2008 Jul

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• Application of Monte Carlo simulation-based photon migration for enhanced understanding of near-infrared (NIR) diffuse reflectance. Part I: Depth of penetration in pharmaceutical materials.

  This is the first of a series of articles applying Monte Carlo simulation-based photon migration to enhance understanding of near-infrared (NIR) diffu…

  Authors: Zhenqi Shi, Carl A Anderson

  Source: Journal of pharmaceutical sciences. 2010 May

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• Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.

  BACKGROUND & AIMS: Identifying shared and disease-specific susceptibility loci for Crohn's disease (CD) and ulcerative colitis (UC) would help define …

  Authors: Carl A Anderson, Dunecan C O Massey, Jeffrey C Barrett, Natalie J Prescott, Mark Tremelling, Sheila A Fisher, Rhian Gwilliam, Jemima Jacob, Elaine R Nimmo, Hazel Drummond,…

  Source: Gastroenterology. 2009 Feb

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• Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.

  Ulcerative colitis is a common form of inflammatory bowel disease with a complex etiology. As part of the Wellcome Trust Case Control Consortium 2, we…

  Authors: UK IBD Genetics Consortium, Jeffrey C Barrett, James C Lee, Charles W Lees, Natalie J Prescott, Carl A Anderson, Anne Phillips, Emma Wesley, Kirstie Parnell, Hu Zhang,…

  Source: Nature genetics. 2009 Dec

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• Common variants at five new loci associated with early-onset inflammatory bowel disease.

  The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common causes of morbidity in children and young adults in the wester…

  Authors: Marcin Imielinski, Robert N Baldassano, Anne Griffiths, Richard K Russell, Vito Annese, Marla Dubinsky, Subra Kugathasan, Jonathan P Bradfield, Thomas D Walters, Patrick Sleiman,…

  Source: Nature genetics. 2009 Dec

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• A simple linear regression method for quantitative trait loci linkage analysis with censored observations.

  Standard quantitative trait loci (QTL) mapping techniques commonly assume that the trait is both fully observed and normally distributed. When conside…

  Authors: Carl A Anderson, Allan F McRae, Peter M Visscher

  Source: Genetics. 2006 Jul

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