1 to 10 of 24 literature results

• Chemical synthesis and biological activity of the neopetrosiamides and their analogues: revision of disulfide bond connectivity.

  Neopetrosiamides A and B (2) from the marine sponge Neopetrosia sp. are two diastereomeric tricyclic peptides that inhibit tumor cell invasion associa…

  Authors: Hongqiang Liu, Marc A Boudreau, Jing Zheng, Randy M Whittal, Pamela Austin, Calvin D Roskelley, Michel Roberge, Raymond J Andersen, John C Vederas

  Source: Journal of the American Chemical Society. 2010 Feb 10

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• Regulation of the BRCA1 promoter in ovarian surface epithelial cells and ovarian carcinoma cells.

  As BRCA1 expression is often suppressed in sporadic ovarian carcinoma we characterized the regulation of the 231nt proximal 'L6' fragment of the BRCA1…

  Authors: Marcia L Graves, Lixin Zhou, Gwen MacDonald, Christopher R Mueller, Calvin D Roskelley

  Source: FEBS letters. 2007 May 1

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• Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma.

  We report that human secretory breast carcinoma (SBC), a rare subtype of infiltrating ductal carcinoma, expresses the ETV6-NTRK3 gene fusion previousl…

  Authors: Cristina Tognon, Stevan R Knezevich, David Huntsman, Calvin D Roskelley, Natalya Melnyk, Joan A Mathers, Laurence Becker, Fatima Carneiro, Nicol MacPherson, Doug Horsman,…

  Source: Cancer cell. 2002 Nov

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• Collagen-IV and laminin-1 regulate estrogen receptor alpha expression and function in mouse mammary epithelial cells.

  The expression level and functional activity of estrogen receptor alpha is an important determinant of breast physiology and breast cancer treatment. …

  Authors: Virginia Novaro, Calvin D Roskelley, Mina J Bissell

  Source: Journal of cell science. 2003 Jul 15

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• The tumor invasion inhibitor dihydromotuporamine C activates RHO, remodels stress fibers and focal adhesions, and stimulates sodium-proton exchange.

  The motuporamines are macrocyclic alkaloids that inhibit tumor cell invasion by an, as yet, unknown mechanism. A structure-activity study recently ide…

  Authors: Lianne M McHardy, Ryan Sinotte, Armelle Troussard, Claire Sheldon, John Church, David E Williams, Raymond J Andersen, Shoukat Dedhar, Michel Roberge, Calvin D Roskelley

  Source: Cancer research. 2004 Feb 15

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• The dominance of the microenvironment in breast and ovarian cancer.

  That cancer development is a multistep process, driven in large part by genetic change, is well established. However, it is becoming increasingly clea…

  Authors: Calvin D Roskelley, Mina J Bissell

  Source: Seminars in cancer biology. 2002 Apr

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• Expression of activated M-Ras in a murine mammary epithelial cell line induces epithelial-mesenchymal transition and tumorigenesis.

  The expression of activated mutants of M-Ras (G22V or Q71L), but not wild-type M-Ras, in a murine mammary epithelial cell line, scp2, resulted in epit…

  Authors: Katherine R Ward, Kai-Xin Zhang, Kai-Xiu Zhang, Aruna M Somasiri, Calvin D Roskelley, John W Schrader

  Source: Oncogene. 2004 Feb 12

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• Overexpression of the anti-adhesin podocalyxin is an independent predictor of breast cancer progression.

  Podocalyxin is a CD34-related cell surface molecule with anti-adhesive qualities. We probed a tissue microarray (n = 272) linked to long-term outcome …

  Authors: Aruna Somasiri, Julie S Nielsen, Nikita Makretsov, Marcia L McCoy, Leah Prentice, C Blake Gilks, Stephen K Chia, Karen A Gelmon, David B Kershaw, David G Huntsman,…

  Source: Cancer research. 2004 Aug 1

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• Avinosol, a meroterpenoid-nucleoside conjugate with antiinvasion activity isolated from the marine sponge Dysidea sp.

  structure: see text] The new meroterpenoids avinosol (1), 3'-aminoavarone (2), and 3'-phenethylaminoavarone (3) have been isolated from the marine spo…

  Authors: Ana R Diaz-Marrero, Pamela Austin, Rob Van Soest, Teatulohi Matainaho, Calvin D Roskelley, Michel Roberge, Raymond J Andersen

  Source: Organic letters. 2006 Aug 17

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• Neopetrosiamides, peptides from the marine sponge Neopetrosia sp. that inhibit amoeboid invasion by human tumor cells.

  structure: see text] Neopetrosiamdes A (1) and B (2), two diastereomeric tricyclic peptides that inhibit amoeboid invasion of human tumor cells, have …

  Authors: David E Williams, Pamela Austin, Ana R Diaz-Marrero, Rob Van Soest, Teatulohi Matainaho, Calvin D Roskelley, Michel Roberge, Raymond J Andersen

  Source: Organic letters. 2005 Sep 15

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