1 to 10 of 3,078 literature results

• Conservation science: A market approach to saving the whales.

  Authors: Christopher Costello, Steven Gaines, Leah R Gerber

  Source: Nature. 2012 Jan 12

  View Full Text

• Visualization of a missing link in retrovirus capsid assembly.

  For a retrovirus such as HIV to be infectious, a properly formed capsid is needed; however, unusually among viruses, retrovirus capsids are highly var…

  Authors: Giovanni Cardone, John G Purdy, Naiqian Cheng, Rebecca C Craven, Alasdair C Steven

  Source: Nature. 2009 Feb 5

  View Free Full Text

• Structure of the human κ-opioid receptor in complex with JDTic.

  Opioid receptors mediate the actions of endogenous and exogenous opioids on many physiological processes, including the regulation of pain, respirator…

  Authors: Huixian Wu, Daniel Wacker, Mauro Mileni, Vsevolod Katritch, Gye Won Han, Eyal Vardy, Wei Liu, Aaron A Thompson, Xi-Ping Huang, F Ivy Carroll,…

  Source: Nature. 2012 Mar 21

  View Full Text

• Structural basis for iron piracy by pathogenic Neisseria.

  Neisseria are obligate human pathogens causing bacterial meningitis, septicaemia and gonorrhoea. Neisseria require iron for survival and can extract i…

  Authors: Nicholas Noinaj, Nicole C Easley, Muse Oke, Naoko Mizuno, James Gumbart, Evzen Boura, Ashley N Steere, Olga Zak, Philip Aisen, Emad Tajkhorshid,…

  Source: Nature. 2012 Mar 1

  View Full Text

• Diversity and modularity of G protein-coupled receptor structures.

  G protein-coupled receptors (GPCRs) comprise the most 'prolific' family of cell membrane proteins, which share a general mechanism of signal transduct…

  Authors: Vsevolod Katritch, Vadim Cherezov, Raymond C Stevens

  Source: Trends in pharmacological sciences. 2012 Jan

  View Full Text

• Structure of the human histamine H1 receptor complex with doxepin.

  The biogenic amine histamine is an important pharmacological mediator involved in pathophysiological processes such as allergies and inflammations. Hi…

  Authors: Tatsuro Shimamura, Mitsunori Shiroishi, Simone Weyand, Hirokazu Tsujimoto, Graeme Winter, Vsevolod Katritch, Ruben Abagyan, Vadim Cherezov, Wei Liu, Gye Won Han,…

  Source: Nature. 2011 Jul 7

  View Full Text

• Signal transduction at a protein synapse.

  Contraction of the bacteriophage T4 tail in the act of host cell penetration represents a massive structural change powered by conformational free ene…

  Authors: Alasdair C Steven

  Source: Cell. 2004 Aug 20

  View Full Text

• Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling.

  Here we describe a mechanism that cancer cells use to survive when flux through the Src/FAK pathway is severely perturbed. Depletion of FAK, detachmen…

  Authors: Emma Sandilands, Bryan Serrels, David G McEwan, Jennifer P Morton, Juan Pablo Macagno, Kenneth McLeod, Craig Stevens, Valerie G Brunton, Wallace Y Langdon, Marcos Vidal,…

  Source: Nature cell biology. 2012 Jan

  View Full Text

• Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications.

  The APOBEC family members are involved in diverse biological functions. APOBEC3G restricts the replication of human immunodeficiency virus (HIV), hepa…

  Authors: Lauren G Holden, Courtney Prochnow, Y Paul Chang, Ronda Bransteitter, Linda Chelico, Udayaditya Sen, Raymond C Stevens, Myron F Goodman, Xiaojiang S Chen

  Source: Nature. 2008 Nov 6

  View Free Full Text

• How to map billions of short reads onto genomes.

  Mapping the vast quantities of short sequence fragments produced by next-generation sequencing platforms is a challenge. What programs are available a…

  Authors: Cole Trapnell, Steven L Salzberg

  Source: Nature biotechnology. 2009 May

  View Free Full Text