1 to 10 of 419 literature results

• Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence.

  Cellular senescence has been recently shown to have an important role in opposing tumour initiation and promotion. Senescence induced by oncogenes or …

  Authors: Hui-Kuan Lin, Zhenbang Chen, Guocan Wang, Caterina Nardella, Szu-Wei Lee, Chan-Hsin Chan, Wei-Lei Yang, Jing Wang, Ainara Egia, Keiichi I Nakayama,…

  Source: Nature. 2010 Mar 18

  View Full Text

• ETS rearrangements and prostate cancer initiation.

  The first recurrent translocation event in prostate cancer has been recently described; it results in the translocation of an ETS (E26 transformation …

  Authors: Brett S Carver, Jennifer Tran, Zhenbang Chen, Arkaitz Carracedo-Perez, Andrea Alimonti, Caterina Nardella, Anuradha Gopalan, Peter T Scardino, Carlos Cordon-Cardo, William Gerald,…

  Source: Nature. 2009 Feb 12

  View Full Text

• Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate.

  Chromosomal translocations involving the ERG locus are frequent events in human prostate cancer pathogenesis; however, the biological role of aberrant…

  Authors: Brett S Carver, Jennifer Tran, Anuradha Gopalan, Zhenbang Chen, Safa Shaikh, Arkaitz Carracedo, Andrea Alimonti, Caterina Nardella, Shohreh Varmeh, Peter T Scardino,…

  Source: Nature genetics. 2009 May

  View Full Text

• Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas.

  Although cancer arises from a combination of mutations in oncogenes and tumour suppressor genes, the extent to which tumour suppressor gene loss is re…

  Authors: Wen Xue, Lars Zender, Cornelius Miething, Ross A Dickins, Eva Hernando, Valery Krizhanovsky, Carlos Cordon-Cardo, Scott W Lowe

  Source: Nature. 2007 Feb 8

  View Full Text

• Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia.

  Gamma-secretase inhibitors (GSIs) block the activation of the oncogenic protein Notch homolog-1 (NOTCH1) in T cell acute lymphoblastic leukemia (T-ALL…

  Authors: Pedro J Real, Valeria Tosello, Teresa Palomero, Mireia Castillo, Eva Hernando, Elisa de Stanchina, Maria Luisa Sulis, Kelly Barnes, Catherine Sawai, Irene Homminga,…

  Source: Nature medicine. 2009 Jan

  View Free Full Text

• Cyfip1 is a putative invasion suppressor in epithelial cancers.

  Identification of bona fide tumor suppressors is often challenging because of the large number of genetic alterations present in most human cancers. T…

  Authors: Jose M Silva, Elena Ezhkova, Javier Silva, Stephen Heart, Mireia Castillo, Yolanda Campos, Veronica Castro, Felix Bonilla, Carlos Cordon-Cardo, Senthil K Muthuswamy,…

  Source: Cell. 2009 Jun 12

  View Free Full Text

• Identification of a tumour suppressor network opposing nuclear Akt function.

  The proto-oncogene AKT (also known as PKB) is activated in many human cancers, mostly owing to loss of the PTEN tumour suppressor. In such tumours, AK…

  Authors: Lloyd C Trotman, Andrea Alimonti, Pier Paolo Scaglioni, Jason A Koutcher, Carlos Cordon-Cardo, Pier Paolo Pandolfi

  Source: Nature. 2006 May 25

  View Free Full Text

• PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR.

  Loss of the promyelocytic leukaemia (PML) tumour suppressor has been observed in several human cancers. The tumour-suppressive function of PML has bee…

  Authors: Rosa Bernardi, Ilhem Guernah, David Jin, Silvia Grisendi, Andrea Alimonti, Julie Teruya-Feldstein, Carlos Cordon-Cardo, M Celeste Simon, Shahin Rafii, Pier Paolo Pandolfi

  Source: Nature. 2006 Aug 17

  View Full Text

• Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage.

  The Mre11 complex (Mre11, Rad50, and Nbs1) and Chk2 have been implicated in the DNA-damage response, an inducible process required for the suppression…

  Authors: Travis H Stracker, Suzana S Couto, Carlos Cordon-Cardo, Tulio Matos, John H J Petrini

  Source: Molecular cell. 2008 Jul 11

  View Free Full Text

• The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas.

  We analyzed the PI3K-AKT signaling cascade in a cohort of sarcomas and found a marked induction of insulin receptor substrate-2 (IRS2) and phosphoryla…

  Authors: Eva Hernando, Elizabeth Charytonowicz, Maria E Dudas, Silvia Menendez, Igor Matushansky, Joslyn Mills, Nicholas D Socci, Nille Behrendt, Li Ma, Robert G Maki,…

  Source: Nature medicine. 2007 Jun

  View Full Text