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10 literature results
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RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci.
Coordinated recombination of homologous antigen receptor loci is thought to be important for allelic exclusion. Here we show that homologous immunoglo…
Authors: Susannah L Hewitt, Bu Yin, Yanhong Ji, Julie Chaumeil, Katarzyna Marszalek, Jeannette Tenthorey, Giorgia Salvagiotto, Natalie Steinel, Laura B Ramsey, Jacques Ghysdael,…
Source: Nature immunology. 2009 Jun
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Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin.
A hallmark of the cellular response to DNA double-strand breaks (DSBs) is histone H2AX phosphorylation in chromatin to generate gamma-H2AX. Here, we d…
Authors: Velibor Savic, Bu Yin, Nancy L Maas, Andrea L Bredemeyer, Andrea C Carpenter, Beth A Helmink, Katherine S Yang-Iott, Barry P Sleckman, Craig H Bassing
Source: Molecular cell. 2009 May 15
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Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (MTAP) die prematurely of T-cell lymphoma.
Large homozygous deletions of 9p21 that inactivate CDKN2A, ARF, and MTAP are common in a wide variety of human cancers. The role for CDKN2A and ARF in…
Authors: Yuwaraj Kadariya, Bu Yin, Baiqing Tang, Susan A Shinton, Eoin P Quinlivan, Xiang Hua, Andres Klein-Szanto, Tahseen I Al-Saleem, Craig H Bassing, Richard R Hardy,…
Source: Cancer research. 2009 Jul 15
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RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci.
Authors: Susannah L Hewitt, Bu Yin, Yanhong Ji, Julie Chaumeil, Katarzyna Marszalek, Jeannette Tenthorey, Giorgia Salvagiotto, Natalie Steinel, Laura B Ramsey, Jacques Ghysdael,…
Source: Nature immunology. 2010 Apr
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RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci.
Authors: Susannah L Hewitt, Bu Yin, Yanhong Ji, Julie Chaumeil, Katarzyna Marszalek, Jeannette Tenthorey, Giorgia Salvagiotto, Natalie Steinel, Laura B Ramsey, Jacques Ghysdael,…
Source: Nature immunology. 2010 Apr
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The sticky business of histone H2AX in V(D)J recombination, maintenance of genomic stability, and suppression of lymphoma.
DNA double strand breaks (DSBs) induced during cellular metabolism, DNA replication, and genomic rearrangement events lead to phosphorylation of the H…
Authors: Bu Yin, Craig H Bassing
Source: Immunologic research. 2008
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ATM prevents unattended DNA double strand breaks on site and in generations to come.
Ataxia telangiectasia (A-T) is a disorder characterized by cerebellar degeneration, immunodeficiency, genomic instability and genetic predisposition t…
Authors: Bu Yin, Velibor Savic, Craig H Bassing
Source: Cancer biology & therapy. 2007 Dec
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ATR and H2AX cooperate in maintaining genome stability under replication stress.
Chromosomal abnormalities are frequently caused by problems encountered during DNA replication. Although the ATR-Chk1 pathway has previously been impl…
Authors: Rebecca A Chanoux, Bu Yin, Karen A Urtishak, Amma Asare, Craig H Bassing, Eric J Brown
Source: The Journal of biological chemistry. 2009 Feb 27
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Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination.
The H2AX core histone variant is phosphorylated in chromatin around DNA double strand breaks (DSBs) and functions through unknown mechanisms to suppre…
Authors: Bu Yin, Velibor Savic, Marisa M Juntilla, Andrea L Bredemeyer, Katherine S Yang-Iott, Beth A Helmink, Gary A Koretzky, Barry P Sleckman, Craig H Bassing
Source: The Journal of experimental medicine. 2009 Nov 23
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V(D)J recombination causes dangerous chromosome liaisons in developing thymocytes.
Authors: Bu Yin, Craig H Bassing
Source: Cell cycle (Georgetown, Tex.). 2009 Aug 15
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