1 to 10 of 21 literature results

• EBV-associated mononucleosis does not induce long-term global deficit in T-cell responsiveness to IL-15.

  It has been reported that infectious mononucleosis (IM)-symptomatic primary Epstein-Barr virus infection produces a global down-regulation of interleu…

  Authors: Julien Giron-Michel, Fanny Menard, Simone Negrini, Aurore Devocelle, Bruno Azzarone, Caroline Besson

  Source: Blood. 2009 May 7

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• Molecular analysis of the methylprednisolone-mediated inhibition of NK-cell function: evidence for different susceptibility of IL-2- versus IL-15-activated NK cells.

  Steroids have been shown to inhibit the function of fresh or IL-2-activated natural killer (NK) cells. Since IL-15 plays a key role in NK-cell develop…

  Authors: Laura Chiossone, Chiara Vitale, Francesca Cottalasso, Sara Moretti, Bruno Azzarone, Lorenzo Moretta, Maria Cristina Mingari

  Source: Blood. 2007 May 1

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• The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways.

  The clonal expansion of chronic lymphocytic leukemia (CLL) cells requires the interaction with the microenvironment and is under the control of severa…

  Authors: Daniela de Totero, Raffaella Meazza, Matteo Capaia, Marina Fabbi, Bruno Azzarone, Enrico Balleari, Marco Gobbi, Giovanna Cutrona, Manlio Ferrarini, Silvano Ferrini

  Source: Blood. 2008 Jan 15

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• Human renal cancer cells express a novel membrane-bound interleukin-15 that induces, in response to the soluble interleukin-15 receptor alpha chain, epithelial-to-mesenchymal transition.

  Although interleukin-15 (IL-15) is a powerful immunomodulatory factor that has been proposed for cancer immunotherapy, its intratumoral expression may…

  Authors: Krystel Khawam, Julien Giron-Michel, Yanhong Gu, Aurélie Perier, Massimo Giuliani, Anne Caignard, Aurore Devocelle, Silvano Ferrini, Marina Fabbi, Bernard Charpentier,…

  Source: Cancer research. 2009 Feb 15

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• Membrane-bound interleukin (IL)-15 on renal tumor cells rescues natural killer cells from IL-2 starvation-induced apoptosis.

  Renal cell carcinoma primary tumors and lung metastases are infiltrated by activated natural killer (NK) cells. Interleukin (IL)-15, a major cytokine …

  Authors: Sebastian Wittnebel, Sylvie Da Rocha, Julien Giron-Michel, Abdelali Jalil, Paule Opolon, Bernard Escudier, Pierre Validire, Krystel Khawam, Salem Chouaib, Bruno Azzarone,…

  Source: Cancer research. 2007 Jun 15

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• Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells.

  Interleukin-21 (IL-21) is a member of the IL-2 cytokine family, which mediates proliferation or growth arrest and apoptosis of normal B cells, dependi…

  Authors: Daniela de Totero, Raffaella Meazza, Simona Zupo, Giovanna Cutrona, Serena Matis, Monica Colombo, Enrico Balleari, Ivana Pierri, Marina Fabbi, Matteo Capaia,…

  Source: Blood. 2006 May 1

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• Altered IFNgamma signaling and preserved susceptibility to activated natural killer cell-mediated lysis of BCR/ABL targets.

  Previous studies have shown that BCR/ABL oncogene, the molecular counterpart of the Ph1 chromosome, could represent a privileged target to natural kil…

  Authors: Christelle Cebo, Ioannis A Voutsadakis, Sylvie Da Rocha, Jean-Henri Bourhis, Abdelali Jalil, Bruno Azzarone, Ali G Turhan, Mounira Chelbi-Alix, Salem Chouaib, Anne Caignard

  Source: Cancer research. 2005 Apr 1

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• Membrane-bound and soluble IL-15/IL-15Ralpha complexes display differential signaling and functions on human hematopoietic progenitors.

  Membrane-bound and soluble interleukin-15 (IL-15)/IL-15 receptor alpha (Ralpha) complexes trigger differential transcription factor activation and fun…

  Authors: Julien Giron-Michel, Massimo Giuliani, Manuela Fogli, Danièle Brouty-Boyé, Silvano Ferrini, Florence Baychelier, Pierre Eid, Caroline Lebousse-Kerdilès, Deniz Durali, Roberto Biassoni,…

  Source: Blood. 2005 Oct 1

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• In human B cells, IL-12 triggers a cascade of molecular events similar to Th1 commitment.

  Two functionally distinct subsets of B cells that produce Th1- and Th2-like patterns of cytokines have recently been identified. Interleukin-12 (IL-12…

  Authors: Deniz Durali, Marie-Ghislaine de Goër de Herve, Julien Giron-Michel, Bruno Azzarone, Jean-François Delfraissy, Yassine Taoufik

  Source: Blood. 2003 Dec 1

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• Differential STAT3, STAT5, and NF-kappaB activation in human hematopoietic progenitors by endogenous interleukin-15: implications in the expression of functional molecules.

  Different forms of interleukin-15 (IL-15) have been identified and shown to elicit different transduction pathways whose impact on hematopoiesis is po…

  Authors: Julien Giron-Michel, Anne Caignard, Manuela Fogli, Daniele Brouty-Boyé, Diane Briard, Marc van Dijk, Raffaella Meazza, Silvano Ferrini, Caroline Lebousse-Kerdilès, Denis Clay,…

  Source: Blood. 2003 Jul 1

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