1 to 5 of 5 literature results

• Cardiotoxicity of the cancer therapeutic agent imatinib mesylate.

  Imatinib mesylate (Gleevec) is a small-molecule inhibitor of the fusion protein Bcr-Abl, the causal agent in chronic myelogenous leukemia. Here we rep…

  Authors: Risto Kerkelä, Luanda Grazette, Rinat Yacobi, Cezar Iliescu, Richard Patten, Cara Beahm, Brian Walters, Sergei Shevtsov, Stéphanie Pesant, Fred J Clubb,…

  Source: Nature medicine. 2006 Aug

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• Deletion of cytosolic phospholipase A2 promotes striated muscle growth.

  Generation of arachidonic acid by the ubiquitously expressed cytosolic phospholipase A2 (PLA2) has a fundamental role in the regulation of cellular ho…

  Authors: Syed Haq, Heiko Kilter, Ashour Michael, Jingzang Tao, Eileen O'Leary, Xio Ming Sun, Brian Walters, Kausik Bhattacharya, Xin Chen, Lei Cui,…

  Source: Nature medicine. 2003 Jul

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• c-Jun N-terminal kinases mediate reactivation of Akt and cardiomyocyte survival after hypoxic injury in vitro and in vivo.

  Akt is a central regulator of cardiomyocyte survival after ischemic injury in vitro and in vivo, but the mechanisms regulating Akt activity in the pos…

  Authors: Zhili Shao, Kausik Bhattacharya, Eileen Hsich, Larry Park, Brian Walters, Ursula Germann, Yow-Ming Wang, John Kyriakis, Ramon Mohanlal, Keisuke Kuida,…

  Source: Circulation research. 2006 Jan 6

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• Stabilization of beta-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth.

  beta-Catenin is a transcriptional activator that regulates embryonic development as part of the Wnt pathway and also plays a role in tumorigenesis. Th…

  Authors: Syed Haq, Ashour Michael, Michele Andreucci, Kausik Bhattacharya, Paolo Dotto, Brian Walters, James Woodgett, Heiko Kilter, Thomas Force

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2003 Apr 15

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• Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart.

  Glycogen synthase kinase (GSK) 3beta is a negative regulator of stress-induced cardiomyocyte hypertrophy. It is not clear, however, if GSK-3beta plays…

  Authors: Ashour Michael, Syed Haq, Xin Chen, Eileen Hsich, Lei Cui, Brian Walters, Zhili Shao, Kausik Bhattacharya, Heiko Kilter, Gordon Huggins,…

  Source: The Journal of biological chemistry. 2004 May 14

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