1 to 10 of 22 literature results

• Unravelling hepatitis C virus replication from genome to function.

  Since the discovery of the hepatitis C virus over 15 years ago, scientists have raced to develop diagnostics, study the virus and find new therapies. …

  Authors: Brett D Lindenbach, Charles M Rice

  Source: Nature. 2005 Aug 18

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• Gumming up the works: DNA polymers as HCV entry inhibitors.

  Authors: Natalie A Counihan, Brett D Lindenbach

  Source: Gastroenterology. 2009 Aug

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• The NS4A protein of hepatitis C virus promotes RNA-coupled ATP hydrolysis by the NS3 helicase.

  Nonstructural protein 3 (NS3) is an essential replicative component of the hepatitis C virus (HCV) and a member of the DExH/D-box family of proteins. …

  Authors: Rudolf K F Beran, Brett D Lindenbach, Anna Marie Pyle

  Source: Journal of virology. 2009 Apr

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• RNAi targeting an animal virus: news from the front.

  Although many eukaryotic organisms exhibit RNA interference, its role as an antiviral pathway is established only for plants. A recent paper demonstra…

  Authors: Brett D Lindenbach, Charles M Rice

  Source: Molecular cell. 2002 May

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• Silencing of USP18 potentiates the antiviral activity of interferon against hepatitis C virus infection.

  BACKGROUND & AIMS: Modulation of the host innate immune response is an attractive means of inhibiting hepatitis C virus (HCV) replication. Having prev…

  Authors: Glenn Randall, Limin Chen, Maryline Panis, Andrew K Fischer, Brett D Lindenbach, Jing Sun, Jenny Heathcote, Charles M Rice, Aled M Edwards, Ian D McGilvray

  Source: Gastroenterology. 2006 Nov

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• Hepatitis C virus NS2 protein contributes to virus particle assembly via opposing epistatic interactions with the E1-E2 glycoprotein and NS3-NS4A enzyme complexes.

  The hepatitis C virus NS2 protein has been recently implicated in virus particle assembly. To further understand the role of NS2 in this process, we c…

  Authors: Tung Phan, Rudolf K F Beran, Christopher Peters, Ivo C Lorenz, Brett D Lindenbach

  Source: Journal of virology. 2009 Sep

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• A novel class of meso-tetrakis-porphyrin derivatives exhibits potent activities against hepatitis C virus genotype 1b replicons in vitro.

  Recent years have seen the rapid advancement of new therapeutic agents against hepatitis C virus (HCV) in response to the need for treatment that is u…

  Authors: Yao Cheng, Lun K Tsou, Jianfeng Cai, Toshihiro Aya, Ginger E Dutschman, Elizabeth A Gullen, Susan P Grill, Annie Pei-Chun Chen, Brett D Lindenbach, Andrew D Hamilton,…

  Source: Antimicrobial agents and chemotherapy. 2010 Jan

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• The C terminus of hepatitis C virus NS4A encodes an electrostatic switch that regulates NS5A hyperphosphorylation and viral replication.

  Hepatitis C virus (HCV) nonstructural protein 4A (NS4A) is only 54 amino acids (aa) in length, yet it is a key regulator of the essential serine prote…

  Authors: Brett D Lindenbach, Béla M Prágai, Roland Montserret, Rudolf K F Beran, Anna M Pyle, François Penin, Charles M Rice

  Source: Journal of virology. 2007 Sep

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• Superinfection exclusion in cells infected with hepatitis C virus.

  Superinfection exclusion is the ability of an established virus infection to interfere with infection by a second virus. In this study, we found that …

  Authors: Donna M Tscherne, Matthew J Evans, Thomas von Hahn, Christopher T Jones, Zania Stamataki, Jane A McKeating, Brett D Lindenbach, Charles M Rice

  Source: Journal of virology. 2007 Apr

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• Time- and temperature-dependent activation of hepatitis C virus for low-pH-triggered entry.

  Hepatitis C virus (HCV) is an important human pathogen associated with chronic liver disease. Recently, based on a genotype 2a isolate, tissue culture…

  Authors: Donna M Tscherne, Christopher T Jones, Matthew J Evans, Brett D Lindenbach, Jane A McKeating, Charles M Rice

  Source: Journal of virology. 2006 Feb

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