1 to 10 of 31 literature results

• Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer.

  Epithelial ovarian tumors present a complex clinical, diagnostic and therapeutic challenge because of the difficulty of early detection, lack of known…

  Authors: Daniela M Dinulescu, Tan A Ince, Bradley J Quade, Sarah A Shafer, Denise Crowley, Tyler Jacks

  Source: Nature medicine. 2005 Jan

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• A spatially and temporally restricted mouse model of soft tissue sarcoma.

  Soft tissue sarcomas are mesenchymal tumors that are fatal in approximately one-third of patients. To explore mechanisms of sarcoma pathogenesis, we h…

  Authors: David G Kirsch, Daniela M Dinulescu, John B Miller, Jan Grimm, Philip M Santiago, Nathan P Young, G Petur Nielsen, Bradley J Quade, Christopher J Chaber, Christian P Schultz,…

  Source: Nature medicine. 2007 Aug

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• Disruption of neurexin 1 associated with autism spectrum disorder.

  Autism is a neurodevelopmental disorder of complex etiology in which genetic factors play a major role. We have implicated the neurexin 1 (NRXN1) gene…

  Authors: Hyung-Goo Kim, Shotaro Kishikawa, Anne W Higgins, Ihn-Sik Seong, Diana J Donovan, Yiping Shen, Eric Lally, Lauren A Weiss, Juliane Najm, Kerstin Kutsche,…

  Source: American journal of human genetics. 2008 Jan

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• Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice.

  We report a female patient with a de novo balanced translocation, 46,X,t(X;2)(p11.2;q37)dn, who exhibits seizures, capillary abnormality, developmenta…

  Authors: Natalia T Leach, Yi Sun, Sebastien Michaud, Yi Zheng, Keith L Ligon, Azra H Ligon, Thomas Sander, Bruce R Korf, Weining Lu, David J Harris,…

  Source: American journal of human genetics. 2007 Apr

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• Constitutional rearrangement of the architectural factor HMGA2: a novel human phenotype including overgrowth and lipomas.

  Although somatic mutations in a number of genes have been associated with development of human tumors, such as lipomas, relatively few examples exist …

  Authors: Azra H Ligon, Steven D P Moore, Melissa A Parisi, Matthew E Mealiffe, David J Harris, Heather L Ferguson, Bradley J Quade, Cynthia C Morton

  Source: American journal of human genetics. 2005 Feb

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• Characterization of apparently balanced chromosomal rearrangements from the developmental genome anatomy project.

  Apparently balanced chromosomal rearrangements in individuals with major congenital anomalies represent natural experiments of gene disruption and dys…

  Authors: Anne W Higgins, Fowzan S Alkuraya, Amy F Bosco, Kerry K Brown, Gail A P Bruns, Diana J Donovan, Robert Eisenman, Yanli Fan, Chantal G Farra, Heather L Ferguson,…

  Source: American journal of human genetics. 2008 Mar

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• Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux.

  Congenital anomalies of the kidney and urinary tract (CAKUT) include vesicoureteral reflux (VUR). VUR is a complex, genetically heterogeneous developm…

  Authors: Weining Lu, Albertien M van Eerde, Xueping Fan, Fabiola Quintero-Rivera, Shashikant Kulkarni, Heather Ferguson, Hyung-Goo Kim, Yanli Fan, Qiongchao Xi, Qing-Gang Li,…

  Source: American journal of human genetics. 2007 Apr

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• Fusion transcripts involving HMGA2 are not a common molecular mechanism in uterine leiomyomata with rearrangements in 12q15.

  Uterine leiomyomata are one of several benign tumors characterized by frequent chromosomal rearrangement involving 12q15. The 12q15 rearrangement in l…

  Authors: Bradley J Quade, Stanislawa Weremowicz, David M Neskey, Roberta Vanni, Carll Ladd, Paola Dal Cin, Cynthia C Morton

  Source: Cancer research. 2003 Mar 15

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• Uterine leiomyomata with t(10;17) disrupt the histone acetyltransferase MORF.

  Benign uterine leiomyomata are the most common tumors in women of reproductive age. One recurring chromosomal aberration in uterine leiomyomata is rea…

  Authors: Steven D P Moore, Steven R Herrick, Tan A Ince, Michael S Kleinman, Paola Dal Cin, Cynthia C Morton, Bradley J Quade

  Source: Cancer research. 2004 Aug 15

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• MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility study.

  The feasibility and safety of magnetic resonance (MR) imaging-guided focused ultrasound surgery for uterine leiomyomas is reported. Sequential sonicat…

  Authors: Clare M C Tempany, Elizabeth A Stewart, Nathan McDannold, Bradley J Quade, Ferenc A Jolesz, Kullervo Hynynen

  Source: Radiology. 2003 Mar

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