1 to 7 of 7 literature results

• Ipr1 gene mediates innate immunity to tuberculosis.

  An estimated eight million people are infected each year with the pathogen Mycobacterium tuberculosis, and more than two million die annually. Yet onl…

  Authors: Hui Pan, Bo-Shiun Yan, Mauricio Rojas, Yuriy V Shebzukhov, Hongwei Zhou, Lester Kobzik, Darren E Higgins, Mark J Daly, Barry R Bloom, Igor Kramnik

  Source: Nature. 2005 Apr 7

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• Novel CD8+ Treg suppress EAE by TGF-beta- and IFN-gamma-dependent mechanisms.

  Although CD8+ Treg-mediated suppression has been described, CD8+ Treg remain poorly characterized. Here we identify a novel subset of CD8+ Treg that e…

  Authors: Mei-Ling Chen, Bo-Shiun Yan, Deneen Kozoriz, Howard L Weiner

  Source: European journal of immunology. 2009 Dec

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• Dominant role of the sst1 locus in pathogenesis of necrotizing lung granulomas during chronic tuberculosis infection and reactivation in genetically resistant hosts.

  Significant host heterogeneity in susceptibility to tuberculosis exists both between and within mammalian species. Using a mouse model of infection wi…

  Authors: Alexander V Pichugin, Bo-Shiun Yan, Alex Sloutsky, Lester Kobzik, Igor Kramnik

  Source: The American journal of pathology. 2009 Jun

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• Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis.

  CD4(+)CD25(+) regulatory T cells (Tregs) are essential for maintaining self-tolerance and immune homeostasis. Here we characterize a novel subset of C…

  Authors: Mei-Ling Chen, Bo-Shiun Yan, Yoshio Bando, Vijay K Kuchroo, Howard L Weiner

  Source: Journal of immunology (Baltimore, Md. : 1950). 2008 Jun 1

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• Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon.

  The mechanisms that allow Mycobacterium tuberculosis (Mtb) to persist in human tissue for decades and to then abruptly cause disease are not clearly u…

  Authors: Ashwani Kumar, Jessy S Deshane, David K Crossman, Subhashini Bolisetty, Bo-Shiun Yan, Igor Kramnik, Anupam Agarwal, Adrie J C Steyn

  Source: The Journal of biological chemistry. 2008 Jun 27

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• Progression of pulmonary tuberculosis and efficiency of bacillus Calmette-Guérin vaccination are genetically controlled via a common sst1-mediated mechanism of innate immunity.

  Using a mouse model for genetic analysis of host resistance to virulent Mycobacterium tuberculosis, we have identified a genetic locus sst1 on mouse c…

  Authors: Bo-Shiun Yan, Alexander V Pichugin, Ousman Jobe, Laura Helming, Evgeniy B Eruslanov, José A Gutiérrez-Pabello, Mauricio Rojas, Yuriy V Shebzukhov, Lester Kobzik, Igor Kramnik

  Source: Journal of immunology (Baltimore, Md. : 1950). 2007 Nov 15

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• The host resistance locus sst1 controls innate immunity to Listeria monocytogenes infection in immunodeficient mice.

  Epidemiological, clinical, and experimental approaches have convincingly demonstrated that host resistance to infection with intracellular pathogens i…

  Authors: Victor Boyartchuk, Mauricio Rojas, Bo-Shiun Yan, Ousman Jobe, Nicholas Hurt, David M Dorfman, Darren E Higgins, William F Dietrich, Igor Kramnik

  Source: Journal of immunology (Baltimore, Md. : 1950). 2004 Oct 15

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