1 to 10 of 246 literature results

• Complement and coagulation: strangers or partners in crime?

  The convergence between complement and the clotting system extends far beyond the chemical nature of the complement and coagulation components, both o…

  Authors: Maciej M Markiewski, Bo Nilsson, Kristina Nilsson Ekdahl, Tom Eirik Mollnes, John D Lambris

  Source: Trends in immunology. 2007 Apr

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• Structures of complement component C3 provide insights into the function and evolution of immunity.

  The mammalian complement system is a phylogenetically ancient cascade system that has a major role in innate and adaptive immunity. Activation of comp…

  Authors: Bert J C Janssen, Eric G Huizinga, Hans C A Raaijmakers, Anja Roos, Mohamed R Daha, Kristina Nilsson-Ekdahl, Bo Nilsson, Piet Gros

  Source: Nature. 2005 Sep 22

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• Activated human platelets induce factor XIIa-mediated contact activation.

  Earlier studies have shown that isolated platelets in buffer systems can promote activation of FXII or amplify contact activation, in the presence of …

  Authors: Jennie Bäck, Javier Sanchez, Graciela Elgue, Kristina Nilsson Ekdahl, Bo Nilsson

  Source: Biochemical and biophysical research communications. 2010 Jan 1

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• Formation of composite endothelial cell-mesenchymal stem cell islets: a novel approach to promote islet revascularization.

  OBJECTIVE: Mesenchymal stem cells (MSCs) contribute to endothelial cell (EC) migration by producing proteases, thereby paving the way into the tissues…

  Authors: Ulrika Johansson, Ida Rasmusson, Simone P Niclou, Naomi Forslund, Linda Gustavsson, Bo Nilsson, Olle Korsgren, Peetra U Magnusson

  Source: Diabetes. 2008 Sep

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• Islet surface heparinization prevents the instant blood-mediated inflammatory reaction in islet transplantation.

  OBJECTIVE: In clinical islet transplantation, the instant blood-mediated inflammatory reaction (IBMIR) is a major factor contributing to the poor init…

  Authors: Sanja Cabric, Javier Sanchez, Torbjörn Lundgren, Aksel Foss, Marie Felldin, Ragnar Källen, Kaija Salmela, Annika Tibell, Gunnar Tufveson, Rolf Larsson,…

  Source: Diabetes. 2007 Aug

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• Acute antibody-mediated complement activation mediates lysis of pancreatic islets cells and may cause tissue loss in clinical islet transplantation.

  BACKGROUND: Clinical islet transplantation is associated with loss of transplanted islets necessitating tissue from more than one donor to obtain insu…

  Authors: Jenny Tjernberg, Kristina N Ekdahl, John D Lambris, Olle Korsgren, Bo Nilsson

  Source: Transplantation. 2008 Apr 27

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• Low molecular weight dextran sulfate is well tolerated in humans and increases endogenous expression of islet protective hepatocyte growth factor.

  INTRODUCTION: Low molecular weight dextran sulfate (LMW-DS) is a strong candidate to prevent early islet graft destruction caused by the instant blood…

  Authors: Peter Schmidt, Caroline Magnusson, Torbjörn Lundgren, Olle Korsgren, Bo Nilsson

  Source: Transplantation. 2008 Dec 15

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• Distinctive regulation of contact activation by antithrombin and C1-inhibitor on activated platelets and material surfaces.

  Activated human plate lets trigger FXII-mediated contact activation, which leads to the generation of FXIIa-antithrombin (AT) and FXIa-AT complexes. T…

  Authors: Jennie Bäck, Markus Huber Lang, Graciela Elgue, Miriam Kalbitz, Javier Sanchez, Kristina Nilsson Ekdahl, Bo Nilsson

  Source: Biomaterials. 2009 Dec

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• Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice.

  In vitro studies suggest that the G protein-coupled receptor (GPR) 30 is a functional estrogen receptor. However, the physiological role of GPR30 in v…

  Authors: Ulrika E A Mårtensson, S Albert Salehi, Sara Windahl, Maria F Gomez, Karl Swärd, Joanna Daszkiewicz-Nilsson, Anna Wendt, Niklas Andersson, Per Hellstrand, Per-Olof Grände,…

  Source: Endocrinology. 2009 Feb

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• Inhibition of complement activation on a model biomaterial surface by streptococcal M protein-derived peptides.

  The aim of this study was to evaluate a new approach to inhibit complement activation triggered by biomaterial surfaces in contact with blood. In orde…

  Authors: Anna E Engberg, Kerstin Sandholm, Fredrik Bexborn, Jenny Persson, Bo Nilsson, Gunnar Lindahl, Kristina N Ekdahl

  Source: Biomaterials. 2009 May

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