1 to 10 of 189 literature results

• The expanding cosmos of nuclear receptor coactivators.

  About 200 coactivators play a central role in promoting gene expression mediated by nuclear receptors. This diverse group of proteins are key integrat…

  Authors: David M Lonard, Bert W O'Malley

  Source: Cell. 2006 May 5

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• SRC-3 coactivator functional lifetime is regulated by a phospho-dependent ubiquitin time clock.

  SRC-3/AIB1 is an important growth coactivator whose activity should be tightly regulated since excess activation results in oncogenesis. Herein, we pr…

  Authors: Ray-Chang Wu, Qin Feng, David M Lonard, Bert W O'Malley

  Source: Cell. 2007 Jun 15

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• Cracking the coregulator codes.

  The study of the genetic code has collectively revealed that the biochemical basis of heredity is uniform for nearly all known forms of life. Genetic …

  Authors: Bert W O'Malley, Jun Qin, Rainer B Lanz

  Source: Current opinion in cell biology. 2008 Jun

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• Nuclear receptor coregulators: judges, juries, and executioners of cellular regulation.

  In a little more than 10 years, nuclear receptor (NR) coregulators (coactivators and corepressors) have contributed to our present realization that a …

  Authors: David M Lonard, Bert W O'malley

  Source: Molecular cell. 2007 Sep 7

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• SRC-3Delta4 mediates the interaction of EGFR with FAK to promote cell migration.

  EGF induces signal transduction between EGFR and FAK, and FAK is required for EGF-induced cell migration. It is unknown, however, what factor mediates…

  Authors: Weiwen Long, Ping Yi, Larbi Amazit, Heather L LaMarca, Felicity Ashcroft, Rakesh Kumar, Michael A Mancini, Sophia Y Tsai, Ming-Jer Tsai, Bert W O'Malley

  Source: Molecular cell. 2010 Feb 12

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• Essential phosphatases and a phospho-degron are critical for regulation of SRC-3/AIB1 coactivator function and turnover.

  SRC-3/AIB1 is a master growth coactivator and oncogene, and phosphorylation activates it into a powerful coregulator. Dephosphorylation is a potential…

  Authors: Chao Li, Yao-Yun Liang, Xin-Hua Feng, Sophia Y Tsai, Ming-Jer Tsai, Bert W O'Malley

  Source: Molecular cell. 2008 Sep 26

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• Nuclear receptor coregulators and human disease.

  Nuclear receptor (NR) coregulators (coactivators and corepressors) are essential elements in regulating nuclear receptor-mediated transcription. In a …

  Authors: David M Lonard, Rainer B Lanz, Bert W O'Malley

  Source: Endocrine reviews. 2007 Aug

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• Nuclear receptor coregulators in cancer biology.

  Coregulators (coactivators and corepressors) occupy the driving seat for actions of all nuclear receptors, and consequently, selective receptor modula…

  Authors: Bert W O'Malley, Rakesh Kumar

  Source: Cancer research. 2009 Nov 1

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• Gene transcription: two worlds merged.

  Authors: David M Lonard, Bert W O'Malley

  Source: Nature. 2008 Apr 24

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• An essential function of the SRC-3 coactivator in suppression of cytokine mRNA translation and inflammatory response.

  Steroid receptor coactivator-3 (SRC-3) is a transcriptional coactivator for nuclear receptors and other transcription factors. Although multiple physi…

  Authors: Chundong Yu, Brian York, Shu Wang, Qin Feng, Jianming Xu, Bert W O'Malley

  Source: Molecular cell. 2007 Mar 9

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