1 to 10 of 22 literature results

• Human T cell responses against melanoma.

  Many antigens recognized by autologous T lymphocytes have been identified on human melanoma. Melanoma patients usually mount a spontaneous T cell resp…

  Authors: Thierry Boon, Pierre G Coulie, Benoît J Van den Eynde, Pierre van der Bruggen

  Source: Annual review of immunology. 2006

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• Processing and presentation of tumor antigens and vaccination strategies.

  Various new aspects of antigen processing have been uncovered through the study of tumor antigens. One of these is the production of antigenic peptide…

  Authors: Pierre van der Bruggen, Benoît J Van den Eynde

  Source: Current opinion in immunology. 2006 Feb

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• Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase.

  T lymphocytes undergo proliferation arrest when exposed to tryptophan shortage, which can be provoked by indoleamine 2,3-dioxygenase (IDO), an enzyme …

  Authors: Catherine Uyttenhove, Luc Pilotte, Ivan Théate, Vincent Stroobant, Didier Colau, Nicolas Parmentier, Thierry Boon, Benoît J Van den Eynde

  Source: Nature medicine. 2003 Oct

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• DDX3Y encodes a class I MHC-restricted H-Y antigen that is expressed in leukemic stem cells.

  The Y chromosome encodes male-specific minor histocompatibility (H-Y) antigens that stimulate T- and B-lymphocyte responses after sex-mismatched allog…

  Authors: Kellie V Rosinski, Nobuharu Fujii, Jeffrey K Mito, Kevin K W Koo, Suzanne M Xuereb, Olga Sala-Torra, James S Gibbs, Jerald P Radich, Yoshiki Akatsuka, Benoît J Van den Eynde,…

  Source: Blood. 2008 May 1

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• Rational design of indoleamine 2,3-dioxygenase inhibitors.

  Indoleamine 2,3-dioxygenase (IDO) is an important therapeutic target for the treatment of diseases such as cancer that involve pathological immune esc…

  Authors: Ute F Röhrig, Loay Awad, Aurélien Grosdidier, Pierre Larrieu, Vincent Stroobant, Didier Colau, Vincenzo Cerundolo, Andrew J G Simpson, Pierre Vogel, Benoît J Van den Eynde,…

  Source: Journal of medicinal chemistry. 2010 Feb 11

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• Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis.

  INTRODUCTION: To identify markers and mechanisms of resistance to adalimumab therapy, we studied global gene expression profiles in synovial tissue sp…

  Authors: Valérie Badot, Christine Galant, Adrien Nzeusseu Toukap, Ivan Theate, Anne-Lise Maudoux, Benoît J Van den Eynde, Patrick Durez, Frédéric A Houssiau, Bernard R Lauwerys

  Source: Arthritis research & therapy. 2009

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• Processing of tumor-associated antigen by the proteasomes of dendritic cells controls in vivo T-cell responses.

  Dendritic cells are unique in their capacity to process antigens and prime naive CD8(+) T cells. Contrary to most cells, which express the standard pr…

  Authors: Laurence Chapatte, Maha Ayyoub, Sandra Morel, Anne-Lise Peitrequin, Nicole Lévy, Catherine Servis, Benoît J Van den Eynde, Danila Valmori, Frédéric Lévy

  Source: Cancer research. 2006 May 15

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• An inducible mouse model of melanoma expressing a defined tumor antigen.

  Cancer immunotherapy based on vaccination with defined tumor antigens has not yet shown strong clinical efficacy, despite promising results in preclin…

  Authors: Ivo J Huijbers, Paul Krimpenfort, Patrick Chomez, Martin A van der Valk, Ji-Ying Song, Else-Marit Inderberg-Suso, Anne-Marie Schmitt-Verhulst, Anton Berns, Benoît J Van den Eynde

  Source: Cancer research. 2006 Mar 15

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• Tumor-specific shared antigenic peptides recognized by human T cells.

  The first tumor-specific shared antigens and the cancer-germline genes that code for these antigens were identified with antitumor cytolytic T lymphoc…

  Authors: Pierre Van Der Bruggen, Yi Zhang, Pascal Chaux, Vincent Stroobant, Christophe Panichelli, Erwin S Schultz, Jacques Chapiro, Benoît J Van Den Eynde, Francis Brasseur, Thierry Boon

  Source: Immunological reviews. 2002 Oct

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• Splicing of distant Peptide fragments occurs in the proteasome by transpeptidation and produces the spliced antigenic peptide derived from fibroblast growth factor-5.

  Peptide splicing is a newly described mode of production of antigenic peptides presented by MHC class I molecules, whereby two noncontiguous fragments…

  Authors: Alexandre Dalet, Nathalie Vigneron, Vincent Stroobant, Ken-Ichi Hanada, Benoît J Van den Eynde

  Source: Journal of immunology (Baltimore, Md. : 1950). 2010 Mar 15

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