1 to 10 of 168 literature results

• Activity-based protein profiling: from enzyme chemistry to proteomic chemistry.

  Genome sequencing projects have provided researchers with a complete inventory of the predicted proteins produced by eukaryotic and prokaryotic organi…

  Authors: Benjamin F Cravatt, Aaron T Wright, John W Kozarich

  Source: Annual review of biochemistry. 2008

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• Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis.

  Tumor cells display progressive changes in metabolism that correlate with malignancy, including development of a lipogenic phenotype. How stored fats …

  Authors: Daniel K Nomura, Jonathan Z Long, Sherry Niessen, Heather S Hoover, Shu-Wing Ng, Benjamin F Cravatt

  Source: Cell. 2010 Jan 8

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• The biological impact of mass-spectrometry-based proteomics.

  In the past decade, there have been remarkable advances in proteomic technologies. Mass spectrometry has emerged as the preferred method for in-depth …

  Authors: Benjamin F Cravatt, Gabriel M Simon, John R Yates

  Source: Nature. 2007 Dec 13

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• Structure and function of fatty acid amide hydrolase.

  Fatty acid amide hydrolase (FAAH) is a mammalian integral membrane enzyme that degrades the fatty acid amide family of endogenous signaling lipids, wh…

  Authors: Michele K McKinney, Benjamin F Cravatt

  Source: Annual review of biochemistry. 2005

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• Global mapping of the topography and magnitude of proteolytic events in apoptosis.

  Proteolysis is a key regulatory process that promotes the (in)activation, translocation, and/or degradation of proteins. As such, there is considerabl…

  Authors: Melissa M Dix, Gabriel M Simon, Benjamin F Cravatt

  Source: Cell. 2008 Aug 22

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• Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes.

  High-throughput screening to discover small-molecule modulators of enzymes typically relies on highly tailored substrate assays, which are not availab…

  Authors: Daniel A Bachovchin, Steven J Brown, Hugh Rosen, Benjamin F Cravatt

  Source: Nature biotechnology. 2009 Apr

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• Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines.

  The nervous system senses peripheral damage through nociceptive neurons that transmit a pain signal. TRPA1 is a member of the Transient Receptor Poten…

  Authors: Lindsey J Macpherson, Adrienne E Dubin, Michael J Evans, Felix Marr, Peter G Schultz, Benjamin F Cravatt, Ardem Patapoutian

  Source: Nature. 2007 Feb 1

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• Identification of protein pheromones that promote aggressive behaviour.

  Mice use pheromones, compounds emitted and detected by members of the same species, as cues to regulate social behaviours such as pup suckling, aggres…

  Authors: Pablo Chamero, Tobias F Marton, Darren W Logan, Kelly Flanagan, Jason R Cruz, Alan Saghatelian, Benjamin F Cravatt, Lisa Stowers

  Source: Nature. 2007 Dec 6

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• Activity-based probes that target functional subclasses of phospholipases in proteomes.

  Phospholipases are a large and diverse set of enzymes that metabolize the phospholipid components of cell membranes and function in key lipid-signalin…

  Authors: Sarah E Tully, Benjamin F Cravatt

  Source: Journal of the American Chemical Society. 2010 Mar 17

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• Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk.

  Lactation is a highly demanding lipid synthesis and transport process that is crucial for the development of newborn mammals. While PPAR gamma is know…

  Authors: Yihong Wan, Alan Saghatelian, Ling-Wa Chong, Chun-Li Zhang, Benjamin F Cravatt, Ronald M Evans

  Source: Genes & development. 2007 Aug 1

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