10 literature results

• Identification of DOK genes as lung tumor suppressors.

  Genome-wide analyses of human lung adenocarcinoma have identified regions of consistent copy-number gain or loss, but in many cases the oncogenes and …

  Authors: Alice H Berger, Masaru Niki, Alessandro Morotti, Barry S Taylor, Nicholas D Socci, Agnes Viale, Cameron Brennan, Janos Szoke, Noriko Motoi, Paul B Rothman,…

  Source: Nature genetics. 2010 Mar

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• Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies.

  Mutation of the gene PARK2, which encodes an E3 ubiquitin ligase, is the most common cause of early-onset Parkinson's disease. In a search for multisi…

  Authors: Selvaraju Veeriah, Barry S Taylor, Shasha Meng, Fang Fang, Emrullah Yilmaz, Igor Vivanco, Manickam Janakiraman, Nikolaus Schultz, Aphrothiti J Hanrahan, William Pao,…

  Source: Nature genetics. 2010 Jan

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• Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis.

  The TMPRSS2-ERG fusion, present in approximately 50% of prostate cancers, is less common in prostatic intraepithelial neoplasia (PIN), raising questio…

  Authors: Jennifer C King, Jin Xu, John Wongvipat, Haley Hieronymus, Brett S Carver, David H Leung, Barry S Taylor, Chris Sander, Robert D Cardiff, Suzana S Couto,…

  Source: Nature genetics. 2009 May

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• A systems approach to model metastatic progression.

  Proteomic profiling of human disease has seen much early activity with the accessibility of the newest generation of high-throughput platforms and tec…

  Authors: Barry S Taylor, Sooryanarayana Varambally, Arul M Chinnaiyan

  Source: Cancer research. 2006 Jun 1

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• Genetic predictors of MEK dependence in non-small cell lung cancer.

  Hyperactivated extracellular signal-regulated kinase (ERK) signaling is common in human cancer and is often the result of activating mutations in BRAF…

  Authors: Christine A Pratilas, Aphrothiti J Hanrahan, Ensar Halilovic, Yogindra Persaud, Junichi Soh, Dhananjay Chitale, Hisayuki Shigematsu, Hiromasa Yamamoto, Ayana Sawai, Manickam Janakiraman,…

  Source: Cancer research. 2008 Nov 15

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• Automated network analysis identifies core pathways in glioblastoma.

  BACKGROUND: Glioblastoma multiforme (GBM) is the most common and aggressive type of brain tumor in humans and the first cancer with comprehensive geno…

  Authors: Ethan Cerami, Emek Demir, Nikolaus Schultz, Barry S Taylor, Chris Sander

  Source: PloS one. 2010

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• V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway.

  Tumors with mutant BRAF and those with receptor tyrosine kinase (RTK) activation have similar levels of phosphorylated ERK, but only the former depend…

  Authors: Christine A Pratilas, Barry S Taylor, Qing Ye, Agnes Viale, Chris Sander, David B Solit, Neal Rosen

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2009 Mar 17

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• Functional copy-number alterations in cancer.

  Understanding the molecular basis of cancer requires characterization of its genetic defects. DNA microarray technologies can provide detailed raw dat…

  Authors: Barry S Taylor, Jordi Barretina, Nicholas D Socci, Penelope Decarolis, Marc Ladanyi, Matthew Meyerson, Samuel Singer, Chris Sander

  Source: PloS one. 2008

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• Humoral response profiling reveals pathways to prostate cancer progression.

  There is considerable evidence for an association between prostate cancer development and inflammation, which results in autoantibody generation again…

  Authors: Barry S Taylor, Manoj Pal, Jianjun Yu, Bharathi Laxman, Shanker Kalyana-Sundaram, Rong Zhao, Anjana Menon, John T Wei, Alexey I Nesvizhskii, Debashis Ghosh,…

  Source: Molecular & cellular proteomics : MCP. 2008 Mar

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• From bytes to bedside: data integration and computational biology for translational cancer research.

  Authors: Jomol P Mathew, Barry S Taylor, Gary D Bader, Saiju Pyarajan, Marco Antoniotti, Arul M Chinnaiyan, Chris Sander, Steven J Burakoff, Bud Mishra

  Source: PLoS computational biology. 2007 Feb 23

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