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Prevention of colon cancer by low doses of celecoxib, a cyclooxygenase inhibitor, administered in diet rich in omega-3 polyunsaturated fatty acids.
Epidemiologic and animal studies suggest that a high-fat diet containing mixed lipids promotes colorectal cancer, whereas fish oil lacks promoting eff…
Authors: Bandaru S Reddy, Jagan M Patlolla, Barbara Simi, S H Wang, Chinthalapally V Rao
Source: Cancer research. 2005 Sep 1
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Green tea polyphenols inhibit colorectal aberrant crypt foci (ACF) formation and prevent oncogenic changes in dysplastic ACF in azoxymethane-treated F344 rats.
Green tea and its constituents have shown cancer-preventive activities in many animal models. In order to prepare for a human trial on the inhibition …
Authors: Hang Xiao, Xingpei Hao, Barbara Simi, Jihyeung Ju, Heyuan Jiang, Bandaru S Reddy, Chung S Yang
Source: Carcinogenesis. 2008 Jan
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Modulation of inducible nitric oxide synthase and related proinflammatory genes by the omega-3 fatty acid docosahexaenoic acid in human colon cancer cells.
Epidemiological and preclinical studies demonstrate that consumption of diets high in omega-3 polyunsaturated fatty acids reduces the risk of colon ca…
Authors: Bhagavathi A Narayanan, Narayanan K Narayanan, Barbara Simi, Bandaru S Reddy
Source: Cancer research. 2003 Mar 1
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Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor.
The inducible isoforms of nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) are overexpressed in colonic tumors of humans, as well as in colon t…
Authors: Chinthalapally V Rao, Cooma Indranie, Barbara Simi, Pamela T Manning, Jane R Connor, Bandaru S Reddy
Source: Cancer research. 2002 Jan 1
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Nitric oxide-releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targets.
Nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NO-NSAID) are promising chemoprevention agents; unlike conventional NSAIDs, they seem fre…
Authors: Chinthalapally V Rao, Bandaru S Reddy, Vernon E Steele, C-X Wang, Xiaoping Liu, Nengtai Ouyang, Jagan M R Patlolla, Barbara Simi, Levy Kopelovich, Basil Rigas
Source: Molecular cancer therapeutics. 2006 Jun
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Modulation of cyclooxygenase-2 activities by the combined action of celecoxib and decosahexaenoic acid: novel strategies for colon cancer prevention and treatment.
To develop efficient synergistic or additive combinations of chemopreventive and nutritional agents to reduce the risk of colon cancer, experiments we…
Authors: Malisetty V Swamy, Indranie Cooma, Jagan M R Patlolla, Barbara Simi, Bandaru S Reddy, Chinthalapally V Rao
Source: Molecular cancer therapeutics. 2004 Feb
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Effects of combination of calcium and aspirin on azoxymethane-induced aberrant crypt foci formation in the colons of mice and rats.
Human intervention studies have suggested an exciting synergistic action between calcium supplementation and aspirin intake in reducing the risk of co…
Authors: Yingying Liu, Jihyeung Ju, Hang Xiao, Barbara Simi, Xingpei Hao, Bandaru S Reddy, Mou-Tuan Huang, Harold Newmark, Chung S Yang
Source: Nutrition and cancer. 2008
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Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced colon carcinogenesis model in rats.
PURPOSE: Epidemiologic studies have linked the consumption of fruits and vegetables to reduced risk of several types of cancer. Laboratory animal mode…
Authors: Nanjoo Suh, Shiby Paul, Xingpei Hao, Barbara Simi, Hang Xiao, Agnes M Rimando, Bandaru S Reddy
Source: Clinical cancer research : an official journal of the American Association for Cancer Research. 2007 Jan 1
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