1 to 5 of 5 literature results

• Substrate-targeting gamma-secretase modulators.

  Selective lowering of Abeta42 levels (the 42-residue isoform of the amyloid-beta peptide) with small-molecule gamma-secretase modulators (GSMs), such …

  Authors: Thomas L Kukar, Thomas B Ladd, Maralyssa A Bann, Patrick C Fraering, Rajeshwar Narlawar, Ghulam M Maharvi, Brent Healy, Robert Chapman, Alfred T Welzel, Robert W Price,…

  Source: Nature. 2008 Jun 12

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• A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease.

  Several approaches have been used in an effort to identify proteins that interact with beta-amyloid precursor protein (APP). However, few studies have…

  Authors: Barbara A Cottrell, Veronica Galvan, Surita Banwait, Olivia Gorostiza, Christian R Lombardo, Tristan Williams, Birgit Schilling, Alyson Peel, Bradford Gibson, Edward H Koo,…

  Source: Annals of neurology. 2005 Aug

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• Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase.

  Proteolytic processing of the amyloid precursor protein by beta- and gamma-secretase generates the amyloid-beta (Abeta) peptides, which are principal …

  Authors: Eva Czirr, Barbara A Cottrell, Stefanie Leuchtenberger, Thomas Kukar, Thomas B Ladd, Hermann Esselmann, Sabine Paul, Robert Schubenel, Justin W Torpey, Claus U Pietrzik,…

  Source: The Journal of biological chemistry. 2008 Jun 20

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• Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals.

  To evaluate the safety and tolerability and pharmacokinetic properties of R-flurbiprofen (Tarenflurbil) in normal elderly individuals and to determine…

  Authors: Douglas R Galasko, Neil Graff-Radford, Susanne May, Suzanne Hendrix, Barbara A Cottrell, Sarah A Sagi, Gary Mather, Mark Laughlin, Kenton H Zavitz, Edward Swabb,…

  Source: Alzheimer disease and associated disorders. 2007 Oct-Dec

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• Increased hippocampal neurogenesis in Alzheimer's disease.

  Neurogenesis, which persists in the adult mammalian brain, may provide a basis for neuronal replacement therapy in neurodegenerative diseases like Alz…

  Authors: Kunlin Jin, Alyson L Peel, Xiao Ou Mao, Lin Xie, Barbara A Cottrell, David C Henshall, David A Greenberg

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2004 Jan 6

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