1 to 10 of 60 literature results

• Distributed network actions by nicotine increase the threshold for spike-timing-dependent plasticity in prefrontal cortex.

  Nicotine enhances attention and working memory by activating nicotinic acetylcholine receptors (nAChRs). The prefrontal cortex (PFC) is critical for t…

  Authors: Jonathan J Couey, Rhiannon M Meredith, Sabine Spijker, Rogier B Poorthuis, August B Smit, Arjen B Brussaard, Huibert D Mansvelder

  Source: Neuron. 2007 Apr 5

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• Functional gene group analysis reveals a role of synaptic heterotrimeric G proteins in cognitive ability.

  Although cognitive ability is a highly heritable complex trait, only a few genes have been identified, explaining relatively low proportions of the ob…

  Authors: Dina Ruano, Gonçalo R Abecasis, Beate Glaser, Esther S Lips, L Niels Cornelisse, Arthur P H de Jong, David M Evans, George Davey Smith, Nicolas J Timpson, August B Smit,…

  Source: American journal of human genetics. 2010 Feb 12

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• Prefrontal cortex AMPA receptor plasticity is crucial for cue-induced relapse to heroin-seeking.

  Associative learning processes have an important role in the initiation and persistence of heroin-seeking. Here we show in a rat self-administration m…

  Authors: Michel C Van den Oever, Natalia A Goriounova, Ka Wan Li, Roel C Van der Schors, Rob Binnekade, Anton N M Schoffelmeer, Huibert D Mansvelder, August B Smit, Sabine Spijker, Taco J De Vries

  Source: Nature neuroscience. 2008 Sep

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• Genome-wide association study of smoking initiation and current smoking.

  For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subj…

  Authors: Jacqueline M Vink, August B Smit, Eco J C de Geus, Patrick Sullivan, Gonneke Willemsen, Jouke-Jan Hottenga, Johannes H Smit, Witte J Hoogendijk, Frans G Zitman, Leena Peltonen,…

  Source: American journal of human genetics. 2009 Mar

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• Acetylcholine binding protein (AChBP): a secreted glial protein that provides a high-resolution model for the extracellular domain of pentameric ligand-gated ion channels.

  Acetylcholine binding protein (AChBP) has recently been identified from molluskan glial cells. Glial cells secrete it into cholinergic synapses, where…

  Authors: Titia K Sixma, August B Smit

  Source: Annual review of biophysics and biomolecular structure. 2003

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• Neuroadaptive effects of active versus passive drug administration in addiction research.

  Increasing knowledge of the genome sequences of several organisms and the development of genome-wide, high-throughput screening techniques for gene ex…

  Authors: Edwin H Jacobs, August B Smit, Taco J de Vries, Anton N M Schoffelmeer

  Source: Trends in pharmacological sciences. 2003 Nov

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• Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures.

  Nicotinic acetylcholine receptors are prototypes for the pharmaceutically important family of pentameric ligand-gated ion channels. Here we present at…

  Authors: Patrick H N Celie, Sarah E van Rossum-Fikkert, Willem J van Dijk, Katjusa Brejc, August B Smit, Titia K Sixma

  Source: Neuron. 2004 Mar 25

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• Insight in nAChR subtype selectivity from AChBP crystal structures.

  Nicotinic acetylcholine receptors (nAChRs) display a broad variety of subtypes, which in turn present a complex subcellular and regional expression pa…

  Authors: Prakash Rucktooa, August B Smit, Titia K Sixma

  Source: Biochemical pharmacology. 2009 Oct 1

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• Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis.

  Acetylcholine binding protein (AChBP) is widely considered as a functional and structural homologue of the ligand binding domain of Cys-loop receptors…

  Authors: Chris Ulens, Atilla Akdemir, Aldo Jongejan, Rene van Elk, Sonia Bertrand, Anastassis Perrakis, Rob Leurs, August B Smit, Titia K Sixma, Daniel Bertrand,…

  Source: Journal of medicinal chemistry. 2009 Apr 23

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• Quantitative proteomics and protein network analysis of hippocampal synapses of CaMKIIalpha mutant mice.

  Quantitative analysis of synaptic proteomes from specific brain regions is important for our understanding of the molecular basis of neuroplasticity a…

  Authors: Ka Wan Li, Stephan Miller, Oleg Klychnikov, Maarten Loos, Jianru Stahl-Zeng, Sabine Spijker, Mark Mayford, August B Smit

  Source: Journal of proteome research. 2007 Aug

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