1 to 4 of 4 literature results

• Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.

  Phosphoinositide 3-kinases (PI3Ks) signal downstream of multiple cell-surface receptor types. Class IA PI3K isoforms couple to tyrosine kinases and co…

  Authors: Mariona Graupera, Julie Guillermet-Guibert, Lazaros C Foukas, Li-Kun Phng, Robert J Cain, Ashreena Salpekar, Wayne Pearce, Stephen Meek, Jaime Millan, Pedro R Cutillas,…

  Source: Nature. 2008 May 29

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• The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.

  The p110 isoforms of phosphoinositide 3-kinase (PI3K) are acutely regulated by extracellular stimuli. The class IA PI3K catalytic subunits (p110alpha,…

  Authors: Julie Guillermet-Guibert, Katja Bjorklof, Ashreena Salpekar, Cristiano Gonella, Faruk Ramadani, Antonio Bilancio, Stephen Meek, Andrew J H Smith, Klaus Okkenhaug, Bart Vanhaesebroeck

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2008 Jun 17

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• Alternately spliced WT1 antisense transcripts interact with WT1 sense RNA and show epigenetic and splicing defects in cancer.

  Many mammalian genes contain overlapping antisense RNAs, but the functions and mechanisms of action of these transcripts are mostly unknown. WT1 is a …

  Authors: Anthony R Dallosso, Anne L Hancock, Sally Malik, Ashreena Salpekar, Linda King-Underwood, Kathy Pritchard-Jones, Jo Peters, Kim Moorwood, Andrew Ward, Karim T A Malik,…

  Source: RNA (New York, N.Y.). 2007 Dec

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• Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice.

  Class IA phosphoinositide 3-kinases (PI3Ks) are a family of p85/p110 heterodimeric lipid kinases that generate second messenger signals downstream of …

  Authors: Klaus Okkenhaug, Antonio Bilancio, Géraldine Farjot, Helen Priddle, Sara Sancho, Emma Peskett, Wayne Pearce, Stephen E Meek, Ashreena Salpekar, Michael D Waterfield,…

  Source: Science (New York, N.Y.). 2002 Aug 9

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