1 to 10 of 28 literature results

• Tenets of PTEN tumor suppression.

  Since its discovery as the elusive tumor suppressor gene at the frequently mutated 10q23 locus, PTEN has been identified as lost or mutated in several…

  Authors: Leonardo Salmena, Arkaitz Carracedo, Pier Paolo Pandolfi

  Source: Cell. 2008 May 2

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• ETS rearrangements and prostate cancer initiation.

  The first recurrent translocation event in prostate cancer has been recently described; it results in the translocation of an ETS (E26 transformation …

  Authors: Brett S Carver, Jennifer Tran, Zhenbang Chen, Arkaitz Carracedo-Perez, Andrea Alimonti, Caterina Nardella, Anuradha Gopalan, Peter T Scardino, Carlos Cordon-Cardo, William Gerald,…

  Source: Nature. 2009 Feb 12

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• The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network.

  Nuclear exclusion of the PTEN (phosphatase and tensin homologue deleted in chromosome 10) tumour suppressor has been associated with cancer progressio…

  Authors: Min Sup Song, Leonardo Salmena, Arkaitz Carracedo, Ainara Egia, Francesco Lo-Coco, Julie Teruya-Feldstein, Pier Paolo Pandolfi

  Source: Nature. 2008 Oct 9

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• Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate.

  Chromosomal translocations involving the ERG locus are frequent events in human prostate cancer pathogenesis; however, the biological role of aberrant…

  Authors: Brett S Carver, Jennifer Tran, Anuradha Gopalan, Zhenbang Chen, Safa Shaikh, Arkaitz Carracedo, Andrea Alimonti, Caterina Nardella, Shohreh Varmeh, Peter T Scardino,…

  Source: Nature genetics. 2009 May

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• Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events.

  The mammalian target of rapamycin (mTOR) represents a critical signaling crossroad where pathways commonly disrupted in cancer converge. We report her…

  Authors: Caterina Nardella, Zhenbang Chen, Leonardo Salmena, Arkaitz Carracedo, Andrea Alimonti, Ainara Egia, Brett Carver, William Gerald, Carlos Cordon-Cardo, Pier Paolo Pandolfi

  Source: Genes & development. 2008 Aug 15

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• SnapShot: PTEN signaling pathways.

  Authors: Arkaitz Carracedo, Leonardo Salmena, Pier Paolo Pandolfi

  Source: Cell. 2008 May 2

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• The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells.

  One of the most exciting areas of current research in the cannabinoid field is the study of the potential application of these compounds as antitumora…

  Authors: Arkaitz Carracedo, Mar Lorente, Ainara Egia, Cristina Blázquez, Stephane García, Valentin Giroux, Cedric Malicet, Raquel Villuendas, Meritxell Gironella, Luis González-Feria,…

  Source: Cancer cell. 2006 Apr

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• High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia.

  To more comprehensively assess the pathogenic contribution of the PTEN-PI3K-AKT pathway to T-cell acute lymphoblastic leukemia (T-ALL), we examined di…

  Authors: Alejandro Gutierrez, Takaomi Sanda, Ruta Grebliunaite, Arkaitz Carracedo, Leonardo Salmena, Yebin Ahn, Suzanne Dahlberg, Donna Neuberg, Lisa A Moreau, Stuart S Winter,…

  Source: Blood. 2009 Jul 16

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• Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression.

  Cannabinoids, the active components of Cannabis sativa L. and their derivatives, inhibit tumor growth in laboratory animals by inducing apoptosis of t…

  Authors: Cristina Blázquez, María Salazar, Arkaitz Carracedo, Mar Lorente, Ainara Egia, Luis González-Feria, Amador Haro, Guillermo Velasco, Manuel Guzmán

  Source: Cancer research. 2008 Mar 15

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• Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes.

  Pancreatic adenocarcinomas are among the most malignant forms of cancer and, therefore, it is of especial interest to set new strategies aimed at impr…

  Authors: Arkaitz Carracedo, Meritxell Gironella, Mar Lorente, Stephane Garcia, Manuel Guzmán, Guillermo Velasco, Juan L Iovanna

  Source: Cancer research. 2006 Jul 1

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