1 to 7 of 7 literature results

• The role of complement in the development of systemic lupus erythematosus.

  Complement has both beneficial and deleterious roles in the pathogenesis of systemic lupus erythematosus (SLE). On the one hand, patients with SLE pre…

  Authors: Anthony P Manderson, Marina Botto, Mark J Walport

  Source: Annual review of immunology. 2004

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• The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus.

  Systemic lupus erythematosus (SLE) is characterised by the production of autoantibodies against ubiquitous antigens, especially nuclear components. Ev…

  Authors: Anthony P Manderson, Francesco Carlucci, Peter J Lachmann, Robert A Lazarus, Richard J Festenstein, H Terence Cook, Mark J Walport, Marina Botto

  Source: Arthritis research & therapy. 2006

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• Monocytosis and accelerated activation of lymphocytes in C1q-deficient autoimmune-prone mice.

  C1q deficiency has been shown to accelerate spontaneous autoimmunity in mice. We studied the time course of activation of monocytes and lymphocytes in…

  Authors: Marten Trendelenburg, Anthony P Manderson, Liliane Fossati-Jimack, Mark J Walport, Marina Botto

  Source: Immunology. 2004 Sep

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• Subcompartments of the macrophage recycling endosome direct the differential secretion of IL-6 and TNFalpha.

  Activated macrophages secrete an array of proinflammatory cytokines, including tumor necrosis factor-alpha (TNFalpha) and interleukin 6 (IL-6), that a…

  Authors: Anthony P Manderson, Jason G Kay, Luke A Hammond, Darren L Brown, Jennifer L Stow

  Source: The Journal of cell biology. 2007 Jul 2

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• SNAREing immunity: the role of SNAREs in the immune system.

  The trafficking of molecules and membranes within cells is a prerequisite for all aspects of cellular immune functions, including the delivery and rec…

  Authors: Jennifer L Stow, Anthony P Manderson, Rachael Z Murray

  Source: Nature reviews. Immunology. 2006 Dec

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• Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice.

  The inflammatory kidney disease membranoproliferative glomerulonephritis type II (MPGN2) is associated with dysregulation of the alternative pathway o…

  Authors: Kirsten L Rose, Danielle Paixao-Cavalcante, Jennifer Fish, Anthony P Manderson, Talat H Malik, Anne E Bygrave, Tao Lin, Steven H Sacks, Mark J Walport, H Terence Cook,…

  Source: The Journal of clinical investigation. 2008 Feb

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• A novel mechanism for complement activation at the surface of B cells following antigen binding.

  Coligation of CD21 with BCR on the surface of B cells provides a costimulatory signal essential for efficient Ab responses to T-dependent Ags. To achi…

  Authors: Anthony P Manderson, Ben Quah, Marina Botto, Chris C Goodnow, Mark J Walport, Chris R Parish

  Source: Journal of immunology (Baltimore, Md. : 1950). 2006 Oct 15

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