1 to 10 of 12 literature results

• Effect of long-term belimumab treatment on B cells in systemic lupus erythematosus: extension of a phase II, double-blind, placebo-controlled, dose-ranging study.

  OBJECTIVE: To understand the effects of long-term BLyS inhibition in human systemic lupus erythematosus (SLE). METHODS: Seventeen patients with SLE wh…

  Authors: Annett M Jacobi, Weiqing Huang, Tao Wang, William Freimuth, Inaki Sanz, Richard Furie, Meggan Mackay, Cynthia Aranow, Betty Diamond, Anne Davidson

  Source: Arthritis and rheumatism. 2010 Jan

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• B cells in autoimmunity.

  B-cell development is tightly regulated, including the induction of B-cell memory and antibody-secreting plasmablasts and plasma cells. In the last de…

  Authors: Thomas Dörner, Annett M Jacobi, Peter E Lipsky

  Source: Arthritis research & therapy. 2009

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• Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: delineation by expression of CD27, IgD, and CD95.

  OBJECTIVE: Analysis of peripheral B cell subsets in patients with systemic lupus erythematosus (SLE) has provided evidence of specific alterations, su…

  Authors: Annett M Jacobi, Karin Reiter, Meggan Mackay, Cynthia Aranow, Falk Hiepe, Andreas Radbruch, Arne Hansen, Gerd-R Burmester, Betty Diamond, Peter E Lipsky,…

  Source: Arthritis and rheumatism. 2008 Jun

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• Generation of migratory antigen-specific plasma blasts and mobilization of resident plasma cells in a secondary immune response.

  Maintenance of protective humoral immunity depends on the generation and survival of antibody-secreting cells. The bone marrow provides niches for lon…

  Authors: Marcus Odendahl, Henrik Mei, Bimba F Hoyer, Annett M Jacobi, Arne Hansen, Gwendolin Muehlinghaus, Claudia Berek, Falk Hiepe, Rudi Manz, Andreas Radbruch,…

  Source: Blood. 2005 Feb 15

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• Polyreactive autoantibodies in systemic lupus erythematosus have pathogenic potential.

  The present study was undertaken to determine whether germline encoded and polyreactive antibodies might be pathogenic and whether the breach of early…

  Authors: Jie Zhang, Annett M Jacobi, Tao Wang, Roseann Berlin, Bruce T Volpe, Betty Diamond

  Source: Journal of autoimmunity. 2009 Nov-Dec

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• Identification of DNA-reactive B cells in patients with systemic lupus erythematosus.

  Autoreactive B cells play a central role in systemic lupus erythematosus (SLE). Characterization of DNA-reactive B cells in the blood of lupus patient…

  Authors: Jie Zhang, Annett M Jacobi, Meggan Mackay, Cynthia Aranow, Tao Wang, Prameladevi Chinnasamy, Betty Diamond

  Source: Journal of immunological methods. 2008 Sep 30

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• Correlation between circulating CD27high plasma cells and disease activity in patients with systemic lupus erythematosus.

  OBJECTIVE: Disease activity in systemic lupus erythematosus (SLE) is usually assessed with complex disease activity scores comprising a variety of dif…

  Authors: Annett M Jacobi, Marcus Odendahl, Karin Reiter, Anne Bruns, Gerd R Burmester, Andreas Radbruch, Günter Valet, Peter E Lipsky, Thomas Dörner

  Source: Arthritis and rheumatism. 2003 May

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• Diminished peripheral blood memory B cells and accumulation of memory B cells in the salivary glands of patients with Sjögren's syndrome.

  OBJECTIVE: To delineate the mechanism of the abnormalities in B cell biology found in patients with primary Sjögren's syndrome (SS). METHODS: The dist…

  Authors: Arne Hansen, Marcus Odendahl, Karin Reiter, Annett M Jacobi, Eugen Feist, Jürgen Scholze, Gerd R Burmester, Peter E Lipsky, Thomas Dörner

  Source: Arthritis and rheumatism. 2002 Aug

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• Pathogenic autoantibodies in systemic lupus erythematosus are derived from both self-reactive and non-self-reactive B cells.

  Previous studies have shown that both murine and human anti-double-stranded DNA (anti-dsDNA) antibodies can develop from non-DNA-reactive B cells and …

  Authors: Jie Zhang, Annett M Jacobi, Tao Wang, Betty Diamond

  Source: Molecular medicine (Cambridge, Mass.). 2008 Nov-Dec

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• Phenotypic characterization of autoreactive B cells--checkpoints of B cell tolerance in patients with systemic lupus erythematosus.

  DNA-reactive B cells play a central role in systemic lupus erythematosus (SLE); DNA antibodies precede clinical disease and in established disease cor…

  Authors: Annett M Jacobi, Jie Zhang, Meggan Mackay, Cynthia Aranow, Betty Diamond

  Source: PloS one. 2009

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