1 to 10 of 29 literature results

• Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events.

  Recently, certain lots of heparin have been associated with an acute, rapid onset of serious side effects indicative of an allergic-type reaction. To …

  Authors: Marco Guerrini, Daniela Beccati, Zachary Shriver, Annamaria Naggi, Karthik Viswanathan, Antonella Bisio, Ishan Capila, Jonathan C Lansing, Sara Guglieri, Blair Fraser,…

  Source: Nature biotechnology. 2008 Jun

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• The tainted heparin story: an update.

  Recently, certain batches of heparin have been associated with an acute, rapid onset of serious side-effects indicative of allergic-type reactions. Th…

  Authors: Marco Guerrini, Zachary Shriver, Antonella Bisio, Annamaria Naggi, Benito Casu, Ram Sasisekharan, Giangiacomo Torri

  Source: Thrombosis and haemostasis. 2009 Nov

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• Heparanase: structure, biological functions, and inhibition by heparin-derived mimetics of heparan sulfate.

  Heparanase is an endoglycosidase which cleaves heparan sulfate (HS) and hence participates in degradation and remodeling of the extracellular matrix (…

  Authors: Israel Vlodavsky, Neta Ilan, Annamaria Naggi, Benito Casu

  Source: Current pharmaceutical design. 2007

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• Structural features of low-molecular-weight heparins affecting their affinity to antithrombin.

  As part of a more extensive investigation on structural features of different low-molecular-weight heparins (LMWHs) that can affect their biological a…

  Authors: Antonella Bisio, Davide Vecchietti, Laura Citterio, Marco Guerrini, Rahul Raman, Sabrina Bertini, Giorgio Eisele, Annamaria Naggi, Ram Sasisekharan, Giangiacomo Torri

  Source: Thrombosis and haemostasis. 2009 Nov

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• The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy.

  The heparan sulfate proteoglycan syndecan-1 is expressed by myeloma cells and shed into the myeloma microenvironment. High levels of shed syndecan-1 i…

  Authors: Yang Yang, Veronica MacLeod, Yuemeng Dai, Yekaterina Khotskaya-Sample, Zachary Shriver, Ganesh Venkataraman, Ram Sasisekharan, Annamaria Naggi, Giangiacomo Torri, Benito Casu,…

  Source: Blood. 2007 Sep 15

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• Interactions of low-molecular-weight semi-synthetic sulfated heparins with human leukocyte elastase and human Cathepsin G.

  Semi-synthetic low-molecular-weight heparin samples (LMWHs), having homogeneous degree of polymerization and saccharide backbone, but differing in the…

  Authors: Claudia Sissi, Lorena Lucatello, Annamaria Naggi, Giangiacomo Torri, Manlio Palumbo

  Source: Biochemical pharmacology. 2006 Jan 12

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• Low molecular weight heparins: structural differentiation by bidimensional nuclear magnetic resonance spectroscopy.

  Individual low molecular weight heparins (LMWHs) exhibit distinct pharmacological and biochemical profiles because of manufacturing differences. Corre…

  Authors: Marco Guerrini, Sara Guglieri, Annamaria Naggi, Ram Sasisekharan, Giangiacomo Torri

  Source: Seminars in thrombosis and hemostasis. 2007 Jul

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• Complex glycosaminoglycans: profiling substitution patterns by two-dimensional nuclear magnetic resonance spectroscopy.

  Biological and pharmacological interactions of heparin and structurally related glycosaminoglycans (GAGs) such as heparan sulfate (HS) involve complex…

  Authors: Marco Guerrini, Annamaria Naggi, Sara Guglieri, Roberto Santarsiero, Giangiacomo Torri

  Source: Analytical biochemistry. 2005 Feb 1

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• Undersulfated, low-molecular-weight glycol-split heparin as an antiangiogenic VEGF antagonist.

  Vascular endothelial growth factor (VEGF) represents a target for antiangiogenic therapies in a wide spectrum of diseases, including cancer. As a nove…

  Authors: Claudio Pisano, Concetta Aulicino, Loredana Vesci, Benito Casu, Annamaria Naggi, Giangiacomo Torri, Domenico Ribatti, Mirella Belleri, Marco Rusnati, Marco Presta

  Source: Glycobiology. 2005 Feb

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• High-performance liquid chromatographic/mass spectrometric studies on the susceptibility of heparin species to cleavage by heparanase.

  Heparanase is an endo-beta-D-glucuronidase that cleaves the heparan sulfate chains of heparan sulfate proteoglycans and is implicated in angiogenesis …

  Authors: Antonella Bisio, Alessandra Mantegazza, Elena Urso, Annamaria Naggi, Giangiacomo Torri, Christian Viskov, Benito Casu

  Source: Seminars in thrombosis and hemostasis. 2007 Jul

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