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• VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo.

  The Aurora kinases are essential for the regulation of chromosome segregation and cytokinesis during mitosis. Aberrant expression and activity of thes…

  Authors: Elizabeth A Harrington, David Bebbington, Jeff Moore, Richele K Rasmussen, Abi O Ajose-Adeogun, Tomoko Nakayama, Joanne A Graham, Cecile Demur, Thierry Hercend, Anita Diu-Hercend,…

  Source: Nature medicine. 2004 Mar

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• Proteomic analysis of brain tissue from an Alzheimer's disease mouse model by two-dimensional difference gel electrophoresis.

  We used a beta-amyloid precursor protein (APP) transgenic (Tg) mouse model that displays some of the typical Alzheimer-associated pathological feature…

  Authors: Daria Sizova, Elodie Charbaut, François Delalande, Florence Poirier, Anthony A High, Fabienne Parker, Alain Van Dorsselaer, Marc Duchesne, Anita Diu-Hercend

  Source: Neurobiology of aging. 2007 Mar

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