1 to 10 of 27 literature results

• Glycolysis: a bioenergetic or a survival pathway?

  Following inhibition of mitochondrial respiration neurons die rapidly, whereas astrocytes utilize glycolytically-generated ATP to increase their mitoc…

  Authors: Juan P Bolaños, Angeles Almeida, Salvador Moncada

  Source: Trends in biochemical sciences. 2010 Mar

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• The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1.

  Neurons are known to have a lower glycolytic rate than astrocytes and when stressed they are unable to upregulate glycolysis because of low Pfkfb3 (6-…

  Authors: Angel Herrero-Mendez, Angeles Almeida, Emilio Fernández, Carolina Maestre, Salvador Moncada, Juan P Bolaños

  Source: Nature cell biology. 2009 Jun

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• Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway.

  After inhibition of cytochrome c oxidase by nitric oxide, astrocytes maintain energy production by upregulating glycolysis--a response which does not …

  Authors: Angeles Almeida, Salvador Moncada, Juan P Bolaños

  Source: Nature cell biology. 2004 Jan

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• Mitochondria and reactive oxygen and nitrogen species in neurological disorders and stroke: Therapeutic implications.

  Mitochondria represent both the main source and target of reactive oxygen and nitrogen species (RONS). In view of the large energy expenditure made by…

  Authors: Juan P Bolaños, Maria A Moro, Ignacio Lizasoain, Angeles Almeida

  Source: Advanced drug delivery reviews. 2009 Nov 30

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• Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid.

  High levels of unconjugated bilirubin (UCB) may initiate encephalopathy in neonatal life, mainly in pre-mature infants. The molecular mechanisms of th…

  Authors: Ana Rita Vaz, Maria Delgado-Esteban, Maria Alexandra Brito, Juan P Bolaños, Dora Brites, Angeles Almeida

  Source: Journal of neurochemistry. 2010 Jan 1

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• The pentose-phosphate pathway in neuronal survival against nitrosative stress.

  Neurons are thought to be particularly vulnerable cells against reactive oxygen and nitrogen species (RONS) damage (nitrosative stress), due in part t…

  Authors: Juan P Bolaños, Angeles Almeida

  Source: IUBMB life. 2010 Jan

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• Increased mitochondrial respiration maintains the mitochondrial membrane potential and promotes survival of cerebellar neurons in an endogenous model of glutamate receptor activation.

  It is thought that the combination of extracellular glutamate accumulation and mitochondrial damage is involved in neuronal death associated with brai…

  Authors: Octavio García, Angeles Almeida, Lourdes Massieu, Juan P Bolaños

  Source: Journal of neurochemistry. 2005 Jan

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• Provoking neuroprotection by peroxynitrite.

  Peroxynitrite, the product of the reaction between nitric oxide and superoxide, is spontaneouly formed within most mammalian cells under physiological…

  Authors: Juan P Bolanos, Paula García-Nogales, Angeles Almeida

  Source: Current pharmaceutical design. 2004

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• Modulation of astroglial energy metabolism by nitric oxide.

  Activated astroglial cells produce large amounts of nitric oxide (NO) which, through the binding to soluble guanylyl cyclase, rapidly increases cyclic…

  Authors: Juan P Bolaños, Angeles Almeida

  Source: Antioxidants & redox signaling. 2006 May-Jun

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• Inhibition of PTEN by peroxynitrite activates the phosphoinositide-3-kinase/Akt neuroprotective signaling pathway.

  Peroxynitrite is usually considered as a neurotoxic nitric oxide-derivative. However, an increasing body of evidence suggests that, at low concentrati…

  Authors: Maria Delgado-Esteban, Dionisio Martin-Zanca, Laura Andres-Martin, Angeles Almeida, Juan P Bolaños

  Source: Journal of neurochemistry. 2007 Jul

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