1 to 10 of 11 literature results

• Loss of p21 permits carcinogenesis from chronically damaged liver and kidney epithelial cells despite unchecked apoptosis.

  Accumulation of toxic metabolites in hereditary tyrosinemia type I (HT1) patients leads to chronic DNA damage and the highest risk for hepatocellular …

  Authors: Holger Willenbring, Amar Deep Sharma, Arndt Vogel, Andrew Y Lee, Andreas Rothfuss, Zhongya Wang, Milton Finegold, Markus Grompe

  Source: Cancer cell. 2008 Jul 8

  View Free Full Text

• Repair kinetics of genomic interstrand DNA cross-links: evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathway.

  The detailed mechanisms of DNA interstrand cross-link (ICL) repair and the involvement of the Fanconi anemia (FA)/BRCA pathway in this process are not…

  Authors: Andreas Rothfuss, Markus Grompe

  Source: Molecular and cellular biology. 2004 Jan

  View Free Full Text

• Computational prediction of the chromosome-damaging potential of chemicals.

  We report on the generation of computer-based models for the prediction of the chromosome-damaging potential of chemicals as assessed in the in vitro …

  Authors: Andreas Rothfuss, Thomas Steger-Hartmann, Nikolaus Heinrich, Jörg Wichard

  Source: Chemical research in toxicology. 2006 Oct

  View Full Text

• Use of computer-assisted prediction of toxic effects of chemical substances.

  The current revision of the European policy for the evaluation of chemicals (REACH) has lead to a controversy with regard to the need of additional an…

  Authors: Brigitte Simon-Hettich, Andreas Rothfuss, Thomas Steger-Hartmann

  Source: Toxicology. 2006 Jul 5

  View Full Text

• Overexpression of heme oxygenase-1 (HO-1) in V79 cells results in increased resistance to hyperbaric oxygen (HBO)-induced DNA damage.

  Heme oxygenase (HO) catalyzes the rate-limiting step in the oxidative degradation of heme to biliverdin. The isoform HO-1 is inducible by a variety of…

  Authors: Andreas Rothfuss, Günter Speit

  Source: Environmental and molecular mutagenesis. 2002

  View Full Text

• Oxygenated water does not induce genotoxic effects in the comet assay.

  Drinking of oxygenated water (i.e. water with increased concentration of physically dissolved oxygen) is said to improve oxygen availability of the bo…

  Authors: Günter Speit, Petra Schütz, Kristina Trenz, Andreas Rothfuss

  Source: Toxicology letters. 2002 Jul 21

  View Full Text

• Towards the creation of an international toxicology information centre.

  A pilot toxicology database system has been created which is accessible on-line via the world-wide web or in-house via an intranet. It is intended to …

  Authors: Philip N Judson, Paul A Cooke, Nancy G Doerrer, Nigel Greene, Robert P Hanzlik, Christopher Hardy, Andreas Hartmann, David Hinchliffe, Julie Holder, Lutz Müller,…

  Source: Toxicology. 2005 Sep 15

  View Full Text

• Reduction of use of animals in regulatory genotoxicity testing: Identification and implementation opportunities-Report from an ECVAM workshop.

  In vivo genetic toxicology tests measure direct DNA damage or the formation of gene or chromosomal mutations, and are used to predict the mutagenic an…

  Authors: Stefan Pfuhler, David Kirkland, Peter Kasper, Makoto Hayashi, Philippe Vanparys, Paul Carmichael, Stephen Dertinger, David Eastmond, Azeddine Elhajouji, Cyrille Krul,…

  Source: Mutation research. 2009 Nov-Dec

  View Full Text

• Investigations on the mechanism of hyperbaric oxygen (HBO)-induced adaptive protection against oxidative stress.

  Hyperbaric oxygen (HBO) treatment of cell cultures is a well suited model for studying genetic and cellular consequences of oxidative stress. We have …

  Authors: Andreas Rothfuss, Günter Speit

  Source: Mutation research. 2002 Oct 31

  View Full Text

• Genotoxicity of hyperbaric oxygen.

  Hyperbaric oxygen (HBO) treatment is applied as a therapy for a wide variety of diseases with symptoms caused by lack of oxygen in the target tissues.…

  Authors: Günter Speit, Claudia Dennog, Peter Radermacher, Andreas Rothfuss

  Source: Mutation research. 2002 Dec

  View Full Text